TH97644B - PDF inhibitors - Google Patents
PDF inhibitorsInfo
- Publication number
- TH97644B TH97644B TH601006596A TH0601006596A TH97644B TH 97644 B TH97644 B TH 97644B TH 601006596 A TH601006596 A TH 601006596A TH 0601006596 A TH0601006596 A TH 0601006596A TH 97644 B TH97644 B TH 97644B
- Authority
- TH
- Thailand
- Prior art keywords
- compound
- alkyl
- formula
- peptidildeformylase
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- -1 2-perimidinyl Chemical group 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 102000002274 Matrix Metalloproteinases Human genes 0.000 abstract 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 125000001151 peptidyl group Chemical group 0.000 abstract 1
Abstract
การประดิษฐ์เกี่ยวข้องกับสารประกอบใหม่ที่คือสารยับยั้งของเปบทิดิล ดีฟอร์มิลเลส (PDF) สารประกอบจะมีประโยชน์โดยเป็นสารต้านแบคทีเรียและยาปฎิชีวนะ สารประกอบตามการประดิษฐ์จะแสดงยับยั้งแบบเลือกเลือกจำเพาะของเปบทิดิล ดีฟอร์มิลเลส ต่อเมททอลโลโปรตีนเนสอื่น ๆ เช่น MMPs วิธีการของการจัดเตรียและการใช้งานของ สารประกอบจะถูกเปิดเผยไว้ด้วยเช่นกัน The invention involves a new compound, an inhibitor of peptidildeformylase (PDF). The compound will be useful as an antibacterial and antibiotic. The fabricated compound exhibited selective inhibition of peptidildeformylase against other metholloproteinase such as MMPs, methods of preparation and the use of peptidyl deformylase. The compound will also be exposed
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH97644B true TH97644B (en) | 2009-08-13 |
| TH97644A TH97644A (en) | 2009-08-13 |
Family
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