TH94387B - New formulation of CDDO methyl ester - Google Patents

Abstract

DC60 (10/11/51) The triterpenoid compound, methyl 2- cyano-3, 12-dioxoliana-1, 9 (11)- diN-28-oate (CDDO methyl ester), has a non-crystalline, glassy solid form and a non-hydrous, crystalline form that can be prepared, for example, from saturated methanol solutions. The glassy form has shown to have a superior biological application value over the non-hydrous, crystalline form. Each form of CDDO methyl ester is a better choice for application, generally in solid form for the treatment of various disease states, commonly associated with inflammation. The triterpenoid compound, methyl 2- cyano-3, 12-dioxoliana-1, 9 (11)- diN-28-oate (CDDO methyl ester), has a non-crystalline, glassy solid form and a non-hydrous, crystalline form that can be prepared, for example, from saturated methanol solutions. The glassy form has shown to have a higher biological application value than the non-hydrous, crystalline form. Non-hydrophobic crystals can be prepared, for example, from saturated methanol solutions. The glassy form has shown to have a superior biological application value over the non-hydrophobic form. Each form of CDDO methyl ester is a better candidate for use, typically in solid form, for the treatment of various disease states, most commonly associated with inflammation.

Claims (1)

1. Micro-pump device Composed - a base plate (3) consisting of one and two faces, with the base plate (3) made of an insulating material - a thin film layer, a floating membrane heater structure consisting of a thin film. A heater (1) built on one surface of the base plate (3) with such an air gap (9) with at least two bonding braces - a thin film layer (2), which Act as a terminal for