TH115355A - A new type of CDDO methyl ester. - Google Patents

Abstract

DC60 (10/11/51) The triterpenoid compound, methyl 2- cyano-3, 12-dioxoliana-1, 9 (11)- diN-28-oate (CDDO methyl ester), has a non-crystalline, glassy solid form and a non-hydrous, crystalline form that can be prepared, for example, from saturated methanol solutions. The glassy form has shown to have a superior biological application value over the non-hydrous, crystalline form. Each form of CDDO methyl ester is a better choice for application, generally in solid form for the treatment of various disease states, commonly associated with inflammation. The triterpenoid compound, methyl 2- cyano-3, 12-dioxoliana-1, 9 (11)- diN-28-oate (CDDO methyl ester), has a non-crystalline, glassy solid form and a non-hydrous, crystalline form that can be prepared, for example, from saturated methanol solutions. The glassy form has shown to have a higher biological application value than the non-hydrous, crystalline form. Non-hydrophobic crystals can be prepared, for example, from saturated methanol solutions. The glassy form has shown to have a superior biological application value over the non-hydrophobic form. Each form of CDDO methyl ester is a better candidate for use, typically in solid form, for the treatment of various disease states, most commonly associated with inflammation.

Claims (3)

: DC60 (10/11/51) triterpenoide compound, methyl 2-cyano-3, 12-dioxoliana-1, 9 (11) - dene-28-. Oate (CDDO methyl ester) has a non-crystalline glass-like form and a It is a non-hydrous crystal that can be prepared, for example, from a saturated methanol solution.The glass-like form has played a greater role in biological usage over the conventional form. Non-hydrous crystal Each form of CDDO methyl ester is a better choice for use. That are generally in solid form for treatment of various states Of disease, which is generally Associated with inflammation Triterpenoid compound, methyl 2-cyano-3,12-- dioxoliana-1, 9 (11) - dien-28-oate (CDDO methyl Esters) have a glass-like, non-crystalline form and a It is a non-hydrous crystal that can be prepared, for example from a solution of saturated methanol, the glassy form, has played a greater role in biological usage over the conventional form. Non-hydrous crystal Each form of CDDO methyl ester is a better choice for use. That are generally in solid form for treatment of various states Of disease, which generally is Associated with arthritic inflammation (Item one) which will appear on the advertisement page: edit 21/7/2016 1. Glass-like solid form. CDDO-methyl ester, with X-ray powder diffraction scheme with 1 peak halo at approximately 13.5 ํ 20 (formula) as shown in Figure 2C and Tg. 2. Sovate Dimethanol form of CDDO-Methyl Ester With powder diffraction An x-ray with characteristic peaks of 8.87, 11.26, 13.72, 16,63, and 16.9, (formula) (formula), (formula) and DSC format, as shown in Figure 24. 3. Pharmacist tag components: drug patents