TH91788B - Benzimidazole and new benzothiazole derivatives, preparation methods for that substance, their use as drugs, pharmaceutical constituents and new uses, in particular, as CMET inhibitors. - Google Patents
Benzimidazole and new benzothiazole derivatives, preparation methods for that substance, their use as drugs, pharmaceutical constituents and new uses, in particular, as CMET inhibitors.Info
- Publication number
- TH91788B TH91788B TH601004710A TH0601004710A TH91788B TH 91788 B TH91788 B TH 91788B TH 601004710 A TH601004710 A TH 601004710A TH 0601004710 A TH0601004710 A TH 0601004710A TH 91788 B TH91788 B TH 91788B
- Authority
- TH
- Thailand
- Prior art keywords
- new
- alkyl
- drugs
- benzimidazole
- substance
- Prior art date
Links
- 239000000126 substance Substances 0.000 title claims abstract 3
- 239000003814 drug Substances 0.000 title abstract 2
- 229940079593 drugs Drugs 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- JYZIHLWOWKMNNX-UHFFFAOYSA-N Benzimidazole Chemical compound C1=C[CH]C2=NC=NC2=C1 JYZIHLWOWKMNNX-UHFFFAOYSA-N 0.000 title 1
- IOJUPLGTWVMSFF-UHFFFAOYSA-N Benzothiazole Chemical class C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 title 1
- 239000000470 constituent Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000005343 heterocyclic alkyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- -1 NR6R7 Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
Abstract
การประดิษฐ์เกี่ยวกับผลิตภัณฑ์ใหม่ที่มีสูตร (I) (สูตรเคมี) (I) ซึ่ง A แสดงแทน NH หรือ S; R1, R2, และ R3 แสดงแทน H, NH2, Hal หรือ Alk; ที่มีอย่างน้อยหนึ่ง หมู่จากในหมู่ R1, R2 และ R3 เป็นนอกเหนือจากไฮโดรเจน; R แสดงแทนเป็นพิเศษคือ: ไซโคล แอลคิล, แอลคิล, แอลคอกซิ หรือ NR4R5 ที่มี R4 ซึ่งแสดงแทน H หรือ Alk และ R5 ซึ่งแสดงแทน ไซโคลแอลคิล หรือ แอลคิล ที่เลือกแทนที่ด้วยไฮดรอกซิล, แอลคอกซิ, เฮเทอโรแอริล, เฮเทอโร ไซโคลแอลคิล, NR6R7, เฟนิล, เฟนิล-NR6R7 และ CONR6R7 ที่มี R6 และ R7 ซึ่งแสดงแทน H หรือ Alk หรือ เฟนิล, และ R6 และ R7 อาจเกิดไซคลิกเเรดิคัลกกับ N; R4 และ R5 อาจเกิดไซคลิก แรดิคัล กับ N; เฮเทอโรไซโคลแอลคิล, เฮเทอโรแอริล และเฟนิลแรดิคัลทั้งหมดข้างต้น ซึ่งถูกเลือกแทนที่, ผลิตภัณฑ์เหล่านี้อยู่ในรูปไอโซเมอร์ใดๆ ของเกลือต่างๆ เป็นยา โดยเฉพาะอย่างยิ่ง เป็นสาร ยับยั้ง Met: The invention of a new product with the formula (I) (chemical formula) (I), where A represents NH or S; R1, R2, and R3 represent H, NH2, Hal or Alk; Containing at least one Among from among R1, R2 and R3 are the addition of hydrogen; R is specially represented as: cycloalkyl, alkyl, alkyl or NR4R5 with R4 representing H or Alk, and R5 representing cycloalkyl, alkyl or alkyl. That were replaced with hydroxyl, alkoxin, heteroeryl, heterocyclic alkyl, NR6R7, phenyl, phenyl-NR6R7 and CONR6R7 with R6 and R7. They represent H or Alk or phenyl, and R6 and R7. Cyclic cyclic may occur with N; R4 and R5 cyclic radical with N; Heterocyclic alkyl, heteroairyl and phenyl radical, all of the above. Which have been chosen to replace, these products are in any form of isomers Of various salts are drugs, especially as Met inhibitors:
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH91788A TH91788A (en) | 2008-10-10 |
| TH91788B true TH91788B (en) | 2008-10-10 |
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