TH92804B - A new type of cyclic urea sulfate derivative, preparation of such substances And its use in pharmaceutical field as a kinase inhibitor. - Google Patents
A new type of cyclic urea sulfate derivative, preparation of such substances And its use in pharmaceutical field as a kinase inhibitor.Info
- Publication number
- TH92804B TH92804B TH701000250A TH0701000250A TH92804B TH 92804 B TH92804 B TH 92804B TH 701000250 A TH701000250 A TH 701000250A TH 0701000250 A TH0701000250 A TH 0701000250A TH 92804 B TH92804 B TH 92804B
- Authority
- TH
- Thailand
- Prior art keywords
- radicals
- substances
- preparation
- new type
- kinase inhibitor
- Prior art date
Links
- 239000000126 substance Substances 0.000 title claims abstract 3
- -1 cyclic urea sulfate derivative Chemical class 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims abstract 3
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 2
- 125000004432 carbon atoms Chemical group C* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000005343 heterocyclic alkyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
Abstract
การประดิษฐ์นี้เกี่ยวข้องกับผลิตภัณฑ์ชนิดใหม่ตามสูตร (I) (สูตรเคมี) (I) โดยที่ n แทน 0 หรือ 2; R แทนไพริดิลหรือไพริมิดินิลซึ่งถูกแทนที่ด้วยอนุมูล NR1R2, หนึ่งใน R1 และ R2 แทนไฮโดรเจนหรือแอลคิล และอีกหนึ่งใน R1 และ R2 แทนไฮโดรเจน หรือแอลคิล, ไซโคลแอลคิล เฮเทอโรไซโคลแอลคิล, เฟนิล, ไพริมิดินิล, ไพริดิล ซึ่งอาจถูกแทนที่ และ CO-R3 โดยที่ R3 ถูกคัดเลือกโดยเฉพาะอย่างยิ่งจากอนุมูลเอมีน, แอลคอกซี, เฮเทอโรไซโคลแอลคิล, แอริล, แอริลอกซี และเฮเทอโรแอริล; อนุมูลเหล่านี้ทั้งหมดอาจถูกแทนที่; และเกลือของผลิตภัณฑ์ดังกล่าว: The invention involved a new product based on the formula (I) (chemical formula) (I), where n represents 0 or 2; R represents pyridyl or pyrimidyline, which is replaced by NR1R2 radicals, one of R1, and R2 instead of hydrogen or alkyl. And the other in R1 and R2 represent hydrogen or alkyl, cycloalkylheterocycloalkyl, phenyl, pyrimidyl, pyridyl, which may be replaced and CO-R3, where R3 is particularly selective from amines, alkoxies, heterocyclic alkyl, aeryl, aeryloxi and heteroaryyl. ; All of these radicals may be replaced; And salt of such products:
Claims (1)
Publications (2)
Publication Number | Publication Date |
---|---|
TH92804A TH92804A (en) | 2008-12-30 |
TH92804B true TH92804B (en) | 2008-12-30 |
Family
ID=
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TW200738684A (en) | Novel sulfated cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors | |
TW200738685A (en) | Novel cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors | |
EA200701176A1 (en) | NEW NAPHTHALINE COMPOUNDS, METHOD OF THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
UA99617C2 (en) | Pyrrolo-nitrogenous heterocyclic derivatives, the preparation and the pharmaceutical use thereof | |
NZ588830A (en) | Inhibitors of protein kinases | |
UA96152C2 (en) | Dihydropyrazolopyrimidinone derivatives | |
EA201300200A1 (en) | N - ((6-AMINOPIRIDIN-3-IL) METHYL) HETEROARILKARBOXAMIDES AS KALLYCREIN INHIBITORS IN PLASMA | |
RS54048B1 (en) | Parasiticidal dihydroisoxazole compounds | |
MX339668B (en) | Substituted pyridyl amide compounds as modulators of the histamine h3 receptor. | |
MX2009007713A (en) | Pyridazine derivatives, processes for their preparation and their use as fungicides. | |
MX344276B (en) | Novel piperidine compound or salt thereof. | |
TW200714598A (en) | Urea derivatives, methods for their manufacture, and uses therefor | |
MY161134A (en) | Piperazine compound having a pgds inhibitory effect | |
EA201170224A1 (en) | NEW IMIDAZO DERIVATIVES [1,2-A] PYRIMIDINES, METHOD OF THEIR PRODUCTION, THEIR APPLICATION AS MEDICINES, PHARMACEUTICAL COMPOSITIONS AND NEW APPLICATIONS, IN PARTICULAR AS INGITIATORS | |
EA201001087A1 (en) | NEW DIHYDROINDOLONIC COMPOUNDS, METHOD OF THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
CR20220014A (en) | 3,6-diamino-pyridazin-3-yl derivatives, pharmaceutical compositions containing them and their uses as pro-apoptotic agents | |
UA87284C2 (en) | Phenylpyridinylpiperazin derivatives, a process to make them and a pharmaceutical composition containing them | |
TW200745048A (en) | Novel benzimidazole and benzothiazole derivatives, preparation process therefor, application thereof as medicaments, pharmaceutical compositions and novel use especially as CMET inhibitors | |
WO2013060744A3 (en) | 1, 2, 4 - oxadiazole derivatives as ethr inhibitors for use in the treatment tuberculosis | |
TH92804B (en) | A new type of cyclic urea sulfate derivative, preparation of such substances And its use in pharmaceutical field as a kinase inhibitor. | |
TH92804A (en) | ||
TR201820925T4 (en) | Azaindol derivative. | |
TH79803B (en) | New compound | |
TH91788A (en) | Benzimidazole and new benzothiazole derivatives, preparation methods for that substance, their use as drugs, pharmaceutical constituents and new uses, in particular, as CMET inhibitors. | |
TH79803A (en) | New compound |