TH80288B - Benzene dioxane piperazine derivative with propulsion inclusions for dopamine-D2 receptors. And the re-suction position of serotonin - Google Patents
Benzene dioxane piperazine derivative with propulsion inclusions for dopamine-D2 receptors. And the re-suction position of serotoninInfo
- Publication number
- TH80288B TH80288B TH501005737A TH0501005737A TH80288B TH 80288 B TH80288 B TH 80288B TH 501005737 A TH501005737 A TH 501005737A TH 0501005737 A TH0501005737 A TH 0501005737A TH 80288 B TH80288 B TH 80288B
- Authority
- TH
- Thailand
- Prior art keywords
- dopamine
- receptors
- serotonin
- inclusions
- propulsion
- Prior art date
Links
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical group C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title abstract 4
- 102000004980 Dopamine D2 Receptors Human genes 0.000 title abstract 2
- 108090001111 Dopamine D2 Receptors Proteins 0.000 title abstract 2
- 229940076279 Serotonin Drugs 0.000 title abstract 2
- -1 Benzene dioxane piperazine derivative Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 4
- 239000000126 substance Substances 0.000 claims abstract 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 229910052736 halogen Chemical group 0.000 claims 1
- 150000002367 halogens Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drugs Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000031068 symbiosis, encompassing mutualism through parasitism Effects 0.000 abstract 1
Abstract
การประดิษฐ์นี้เกี่ยวข้องกับกลุ่มของอนุพันธ์ 3-(2-พิเพอริดิน-4-อิล-เอทิล)-1H-อินโดลชนิด ใหม่ที่มีแบบการออกฤทธิ์คู่ การยับยั้งการดูดซ้ำของเซอโรโทนินและสัมพรรคภาพสำหรับตัวรับ โดพามีน-D2 และเกี่ยวข้องกับวิธีการสำหรับการเตรียมสารประกอบเหล่านี้ การประดิษฐ์นี่ยังเกี่ยวข้อง กับการใช้สารประกอบที่เปิดเผยในที่นี้สำหรับการผลิตยารักษาโรคเพื่อให้ผลที่เป็นประโยชน์ สารประกอบมีสูตรทั่วไป (1) (สูตรเคมี) (1) ในที่ซึ่งสัญลักษณ์มีความหมายที่ให้ในรายละเอียดเฉพาะ: This invention involves a group of derivatives. 3- (2-piperidin-4-il-ethyl) -1H-indole type New with a dual action Inhibition of serotonin reabsorption and symbiosis for dopamine-D2 receptors and was involved in a method for the preparation of these compounds. Invention is also relevant. Against the use of the compounds disclosed here for the manufacture of medicines to provide beneficial effects Compounds have a general formula (1) (chemical formula) (1) where the symbol has a meaning given in specific detail:
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH80288A TH80288A (en) | 2006-10-12 |
| TH80288B true TH80288B (en) | 2006-10-12 |
Family
ID=
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