TH80288A - Benzene dioxane piperazine derivatives with propulsion inclusions for dopamine-D2 receptors. And the re-suction position of serotonin - Google Patents

Abstract

DC60 (03/03/49) This invention relates to a group of novel 3-(2-piperidin-4-yl-ethyl)-1H-indole derivatives with a dual mode of action: inhibition of serotonin reuptake and affinity for the dopamine-D2 receptor and relates to methods for the preparation of these compounds. This invention also relates to the use of the compounds revealed herein for the manufacture of therapeutic drugs to produce beneficial effects. The compounds have the general formula (1) (chemical formula) (1), where the symbols have the meanings given in specific detail. This invention relates to a group of novel 3-(2-piperidin-4-yl-ethyl)-1H-indole derivatives with a dual mode of action: inhibition of serotonin reuptake and affinity for the dopamine-D2 receptor and relates to methods for the preparation of these compounds. This invention also relates to the use of the compounds revealed herein for the manufacture of therapeutic drugs to produce beneficial effects. The compounds have the general formula (1) (chemical formula) (1), where the symbols have the meanings given in specific detail.

Claims (1)

1. General formula compound (1): (chemical formula) (1) where - Y is CH2, O or S - X is CH2, O, NH or S - m is 1, 3, 5 or 6, - n is 0, 1, 2, or 3 - R4 is hydrogen or halogen - R2 and R3 are independent H or alkyl (C1-3) or R2 + R3 instead of moo - (CH2) -p where P is value. 3,4 or 5 and - R1 is alkyl (C1-3), alcoxetag: drug patent.