TH57310C3 - - Google Patents
Info
- Publication number
- TH57310C3 TH57310C3 TH9901002967A TH9901002967A TH57310C3 TH 57310 C3 TH57310 C3 TH 57310C3 TH 9901002967 A TH9901002967 A TH 9901002967A TH 9901002967 A TH9901002967 A TH 9901002967A TH 57310 C3 TH57310 C3 TH 57310C3
- Authority
- TH
- Thailand
- Prior art keywords
- alkyl
- replaced
- chemical formula
- formula
- amino
- Prior art date
Links
- 239000000126 substance Substances 0.000 claims abstract 252
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 224
- 125000000217 alkyl group Chemical group 0.000 claims abstract 210
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract 126
- 150000001875 compounds Chemical class 0.000 claims abstract 124
- 125000003368 amide group Chemical group 0.000 claims abstract 115
- 150000001408 amides Chemical class 0.000 claims abstract 88
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 87
- XFZRQAZGUOTJCS-UHFFFAOYSA-N phosphoric acid;1,3,5-triazine-2,4,6-triamine Chemical compound OP(O)(O)=O.NC1=NC(N)=NC(N)=N1 XFZRQAZGUOTJCS-UHFFFAOYSA-N 0.000 claims abstract 70
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract 63
- -1 Hydroxylkyl Chemical group 0.000 claims abstract 53
- 125000005843 halogen group Chemical group 0.000 claims abstract 43
- 125000003118 aryl group Chemical group 0.000 claims abstract 34
- 125000002252 acyl group Chemical group 0.000 claims abstract 32
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims abstract 31
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 claims abstract 21
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 17
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract 12
- 150000007942 carboxylates Chemical class 0.000 claims abstract 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract 9
- 125000001188 haloalkyl group Chemical group 0.000 claims abstract 8
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims abstract 8
- 125000004966 cyanoalkyl group Chemical group 0.000 claims abstract 7
- AEOCXXJPGCBFJA-UHFFFAOYSA-N ethionamide Chemical compound CCC1=CC(C(N)=S)=CC=N1 AEOCXXJPGCBFJA-UHFFFAOYSA-N 0.000 claims abstract 7
- 150000002148 esters Chemical class 0.000 claims abstract 6
- 229910052736 halogen Inorganic materials 0.000 claims abstract 6
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 6
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims abstract 5
- 230000003287 optical effect Effects 0.000 claims abstract 5
- 150000003839 salts Chemical class 0.000 claims abstract 5
- 229920006395 saturated elastomer Polymers 0.000 claims abstract 3
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 125
- 229920002554 vinyl polymer Chemical group 0.000 claims 37
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 35
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 33
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 30
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 22
- USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical group C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 claims 14
- 108090000765 processed proteins & peptides Proteins 0.000 claims 13
- 102220470957 Amiloride-sensitive sodium channel subunit delta_R21A_mutation Human genes 0.000 claims 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 12
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 11
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 9
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 8
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 8
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 6
- 150000001412 amines Chemical class 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- OMOVVBIIQSXZSZ-UHFFFAOYSA-N [6-(4-acetyloxy-5,9a-dimethyl-2,7-dioxo-4,5a,6,9-tetrahydro-3h-pyrano[3,4-b]oxepin-5-yl)-5-formyloxy-3-(furan-3-yl)-3a-methyl-7-methylidene-1a,2,3,4,5,6-hexahydroindeno[1,7a-b]oxiren-4-yl] 2-hydroxy-3-methylpentanoate Chemical compound CC12C(OC(=O)C(O)C(C)CC)C(OC=O)C(C3(C)C(CC(=O)OC4(C)COC(=O)CC43)OC(C)=O)C(=C)C32OC3CC1C=1C=COC=1 OMOVVBIIQSXZSZ-UHFFFAOYSA-N 0.000 claims 5
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 5
- 206010011703 Cyanosis Diseases 0.000 claims 4
- 150000001413 amino acids Chemical group 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 238000002360 preparation method Methods 0.000 claims 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 3
- 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 claims 3
- 125000006083 1-bromoethyl group Chemical group 0.000 claims 3
- TXHAHOVNFDVCCC-UHFFFAOYSA-N 2-(tert-butylazaniumyl)acetate Chemical compound CC(C)(C)NCC(O)=O TXHAHOVNFDVCCC-UHFFFAOYSA-N 0.000 claims 3
- 125000005999 2-bromoethyl group Chemical group 0.000 claims 3
- 102220479492 NAD(+) hydrolase SARM1_R22A_mutation Human genes 0.000 claims 3
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 3
- MTCFGRXMJLQNBG-UHFFFAOYSA-N serine Chemical compound OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- 125000003396 thiol group Chemical class [H]S* 0.000 claims 3
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 2
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical group NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 claims 2
- 241001024304 Mino Species 0.000 claims 2
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 claims 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- 239000004365 Protease Substances 0.000 claims 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 2
- 241000234314 Zingiber Species 0.000 claims 2
- 235000006886 Zingiber officinale Nutrition 0.000 claims 2
- 239000003513 alkali Substances 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 230000008878 coupling Effects 0.000 claims 2
- 238000010168 coupling process Methods 0.000 claims 2
- 238000005859 coupling reaction Methods 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 235000008397 ginger Nutrition 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000011159 matrix material Substances 0.000 claims 2
- 125000004963 sulfonylalkyl group Chemical group 0.000 claims 2
- OQOGEOLRYAOSKO-UHFFFAOYSA-N 1,1-dichloro-1-nitroethane Chemical compound CC(Cl)(Cl)[N+]([O-])=O OQOGEOLRYAOSKO-UHFFFAOYSA-N 0.000 claims 1
- 125000005979 2-naphthyloxy group Chemical group 0.000 claims 1
- 108700023418 Amidases Chemical group 0.000 claims 1
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- 241000208474 Protea Species 0.000 claims 1
- 239000004783 Serene Substances 0.000 claims 1
- 102000012479 Serine Proteases Human genes 0.000 claims 1
- 108010022999 Serine Proteases Proteins 0.000 claims 1
- 101800001838 Serine protease/helicase NS3 Proteins 0.000 claims 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical group OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000005907 alkyl ester group Chemical group 0.000 claims 1
- 102000005922 amidase Human genes 0.000 claims 1
- UGJQDKYTAYNNBH-UHFFFAOYSA-N amino cyclopropanecarboxylate Chemical group NOC(=O)C1CC1 UGJQDKYTAYNNBH-UHFFFAOYSA-N 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 230000000840 anti-viral effect Effects 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 230000001427 coherent effect Effects 0.000 claims 1
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 230000007123 defense Effects 0.000 claims 1
- MHDVGSVTJDSBDK-UHFFFAOYSA-N dibenzyl ether Chemical compound C=1C=CC=CC=1COCC1=CC=CC=C1 MHDVGSVTJDSBDK-UHFFFAOYSA-N 0.000 claims 1
- 238000006073 displacement reaction Methods 0.000 claims 1
- LFVPBERIVUNMGV-UHFFFAOYSA-N fasudil hydrochloride Chemical compound Cl.C=1C=CC2=CN=CC=C2C=1S(=O)(=O)N1CCCNCC1 LFVPBERIVUNMGV-UHFFFAOYSA-N 0.000 claims 1
- LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 claims 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000002825 nitriles Chemical class 0.000 claims 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 1
- 238000005897 peptide coupling reaction Methods 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH59047A3 TH59047A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2003-10-28 |
| TH57310C3 true TH57310C3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2017-09-08 |
Family
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