TH43750B - Methods for the production of nucleoside-5'-phosphate esters. - Google Patents
Methods for the production of nucleoside-5'-phosphate esters.Info
- Publication number
- TH43750B TH43750B TH101002467A TH0101002467A TH43750B TH 43750 B TH43750 B TH 43750B TH 101002467 A TH101002467 A TH 101002467A TH 0101002467 A TH0101002467 A TH 0101002467A TH 43750 B TH43750 B TH 43750B
- Authority
- TH
- Thailand
- Prior art keywords
- nucleoside
- nucleosides
- phosphate
- precursors
- crushed
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 238000000034 method Methods 0.000 title claims 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 2
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 2
- 229910052759 nickel Inorganic materials 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 229910052684 Cerium Inorganic materials 0.000 claims 1
- 229910052692 Dysprosium Inorganic materials 0.000 claims 1
- 229910052691 Erbium Inorganic materials 0.000 claims 1
- 229910052693 Europium Inorganic materials 0.000 claims 1
- 229910052689 Holmium Inorganic materials 0.000 claims 1
- 229910052779 Neodymium Inorganic materials 0.000 claims 1
- 229910052777 Praseodymium Inorganic materials 0.000 claims 1
- 229910052772 Samarium Inorganic materials 0.000 claims 1
- 229910052771 Terbium Inorganic materials 0.000 claims 1
- 229910052769 Ytterbium Inorganic materials 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 229910052804 chromium Inorganic materials 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 229910052746 lanthanum Inorganic materials 0.000 claims 1
- 229910052748 manganese Inorganic materials 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229910052750 molybdenum Inorganic materials 0.000 claims 1
- 229910052718 tin Inorganic materials 0.000 claims 1
- 229910052719 titanium Inorganic materials 0.000 claims 1
- 229910052721 tungsten Inorganic materials 0.000 claims 1
- 229910052727 yttrium Inorganic materials 0.000 claims 1
- 229910052725 zinc Inorganic materials 0.000 claims 1
- 229910052726 zirconium Inorganic materials 0.000 claims 1
- 239000002777 nucleoside Substances 0.000 abstract 8
- 125000003835 nucleoside group Chemical group 0.000 abstract 5
- 229910019142 PO4 Inorganic materials 0.000 abstract 4
- 239000010452 phosphate Substances 0.000 abstract 4
- 239000002243 precursor Substances 0.000 abstract 4
- 239000013078 crystal Substances 0.000 abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 abstract 2
- 239000003054 catalyst Substances 0.000 abstract 1
- -1 phosphate ester Chemical class 0.000 abstract 1
Abstract
DC60 (05/04/56) ผลึกของนิวคลีโอไซด์ หรือสารตั้งต้นของดังกล่าว ถูกบดโดยการทำทางกายภาพเพื่อให้มี พื้นที่ผิวเฉพาะที่ 0.4 ม. ตารางเมตร /กรัม หรือมากกว่า, และผลึกที่ถูกบดนิวคลีโอไซด์ หรือ สารตั้งต้นของสารดัง กล่าว ถูกปล่อยให้ทำปฏิกิริยากับตัวให้ฟอสเฟทในที่มีเอนไซม์ตัวเร่งปฏิกิริยาเพื่อให้นิวคลีโอไซด์ ถูก เติมหมู่ฟอสเฟท เพื่อผลิต นิวคลีโอไซด์ - 5' -ฟอสเฟท เอสเตอร์ ผลึกของนิวคลีโอไซด์ หรือสารตั้งต้นของดังกล่าว ถูกบดโดยการทำทางกายภาพเพื่อให้มี พื้นที่ผิวเฉพาะที่ 0.4 ม. 2/กรัม หรือมากกว่า, และผลึกที่ถูกบดนิวคลีโอไซด์ หรือ สารตั้งต้นของสารดัง กล่าว ถูกปล่อยให้ทำปฎิกิริยากับตัวให้ฟอสเฟทในที่มีเอนไซม์ตัวเร่งปฏิกิริยาเพื่อให้นิวคลีโอไซด์ ถูก เติมหมู่ฟอสเฟท เพื่อผลิต นิวคลีโอไซด์ - 5' -ฟอสเฟท เอสเตอร์ DC60 (05/04/56) Nucleoside crystals Or the precursors of such Was crushed by physical work to have The local surface area of 0.4 m m / g or more, and the crushed crystals, the nucleosides, or their precursors are allowed to react with the phosphate in the presence of enzymes. Catalyzed the nucleosides to be added to phosphate groups to produce nucleosides - 5 '- nucleoside crystalline phosphate ester. Or the precursors of such Was crushed by physical work to have The local surface area of 0.4 m 2 / g or more, and the crushed crystals, the nucleosides, or their precursors were allowed to react with the enzyme phosphate. Catalyst for the nucleosides to be added to phosphate groups to produce nucleoside - 5 '- phosphate ester
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH53011A TH53011A (en) | 2002-09-09 |
| TH43750B true TH43750B (en) | 2015-04-10 |
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