TH24376A - - Google Patents

Info

Publication number

TH24376A

TH24376A TH9501002686A TH9501002686A TH24376A TH 24376 A TH24376 A TH 24376A TH 9501002686 A TH9501002686 A TH 9501002686A TH 9501002686 A TH9501002686 A TH 9501002686A TH 24376 A TH24376 A TH 24376A

Authority

TH

Thailand

Prior art keywords

alkyl

replaced

amino

formula

methyl

Prior art date

1995-10-25

Links

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• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 20
• 150000001875 compounds Chemical class 0.000 claims abstract 16
• 239000000126 substance Substances 0.000 claims abstract 12
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 9
• 229910052739 hydrogen Inorganic materials 0.000 claims abstract 6
• 239000001257 hydrogen Substances 0.000 claims abstract 6
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 6
• 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims abstract 4
• 239000003814 drug Substances 0.000 claims abstract 4
• 229940079593 drug Drugs 0.000 claims abstract 4
• 239000000203 mixture Substances 0.000 claims abstract 4
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims abstract 3
• 150000001204 N-oxides Chemical class 0.000 claims abstract 3
• 150000008043 acidic salts Chemical class 0.000 claims abstract 3
• 125000000623 heterocyclic group Chemical group 0.000 claims abstract 2
• 238000002360 preparation method Methods 0.000 claims abstract 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
• 125000005843 halogen group Chemical group 0.000 claims 6
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 6
• 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 claims 5
• 238000006467 substitution reaction Methods 0.000 claims 5
• 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 5
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 4
• -1 aryl tetrazole Chemical class 0.000 claims 4
• GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 claims 4
• 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 3
• 150000003839 salts Chemical class 0.000 claims 3
• 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 2
• XILPCSMEKCBYFO-UHFFFAOYSA-N 4-methyl-1,2,4-triazole Chemical compound CN1C=NN=C1 XILPCSMEKCBYFO-UHFFFAOYSA-N 0.000 claims 2
• CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 2
• 239000002253 acid Substances 0.000 claims 2
• 125000000217 alkyl group Chemical group 0.000 claims 2
• 239000000543 intermediate Substances 0.000 claims 2
• UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 2
• 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
• 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
• 241001024304 Mino Species 0.000 claims 1
• FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
• 150000007513 acids Chemical class 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• 239000003513 alkali Substances 0.000 claims 1
• 229950003476 aminothiazole Drugs 0.000 claims 1
• 125000003118 aryl group Chemical group 0.000 claims 1
• 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 125000004432 carbon atom Chemical group C* 0.000 claims 1
• 125000001309 chloro group Chemical group Cl* 0.000 claims 1
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 238000006073 displacement reaction Methods 0.000 claims 1
• 125000001153 fluoro group Chemical group F* 0.000 claims 1
• 239000012458 free base Substances 0.000 claims 1
• 125000000524 functional group Chemical group 0.000 claims 1
• 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 231100000252 nontoxic Toxicity 0.000 claims 1
• 230000003000 nontoxic effect Effects 0.000 claims 1
• WHLAXDUXKMECTM-UHFFFAOYSA-N oxadiazol-4-amine Chemical compound NC1=CON=N1 WHLAXDUXKMECTM-UHFFFAOYSA-N 0.000 claims 1
• 230000020477 pH reduction Effects 0.000 claims 1
• 125000003538 pentan-3-yl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])[H] 0.000 claims 1
• 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 1
• 150000003431 steroids Chemical class 0.000 claims 1
• 125000004434 sulfur atom Chemical group 0.000 claims 1
• 150000003536 tetrazoles Chemical class 0.000 claims 1
• 238000011287 therapeutic dose Methods 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• 125000004953 trihalomethyl group Chemical group 0.000 claims 1
• 125000001475 halogen functional group Chemical group 0.000 abstract 2
• 239000003524 antilipemic agent Substances 0.000 abstract 1
• 125000004043 oxo group Chemical group O=* 0.000 abstract 1