TH2164B - How to treat depression as well 5- (amino-alkyl) -11-phenyl-5H-diphenyl [b, e] [1,4] diacepbin - Google Patents

Abstract

There are also proposed treatments for depression. 5-(aminoalkyl)-11-phenyl-5H-dibenzo [b,e][1,4] diazeppine, where R to the 1st power and R The power of 2 chooses from hydrogen or methyl and X chooses from hydrogen, chlorine, bromine or fluorine.

Claims (1)

1. Process for preparing substances Which is selected from compounds with a formula where X is selected from a group containing hydrogen, chlorine, bromine or fluorine, R to the 1 power and R to the 2 power, both hydrogen or R to the 1 power hydrogen when R is the second power methyl and The salts obtained by the addition of acids of these substances are used in This process consists of the following steps: Step 1) Ortho-Nitrophenylamine is added to the reducing alkyl group. Using a solution of 3- (1-Phthalimido) -1-chloropropane to obtain a substance N-3-3 (1-phthalimido) propyl-ortho-nitrophenylamine with the formula of step 2) is reduced to the prepared substance in the step 2. 1 to obtain n- [3- (1- Phthalimido) propyl] - ortho-aminodiphenylamine, whose formula step 3) reacts the substance that It was prepared in step 2 with benzyl chloride, which was formulated to obtain n- [3 (phthalimido) propyl] - ortho-benzamidophenilla. The compound which was prepared in step 3 gave 5- (3-phthalimidopil) -11-phen. Nyl-5H-dibenzo [b, e] [1,4] diacepene with the fifth step formula) reacts the compound. The preparation was obtained in step 4 with hydrazine and acid to obtain 5- (3-amino-propyl) -11-phenyl -5H-dibenzo [b, e] [1,4]. Diacepene, which has a formula where R to the power of 1 and R to the second power, is both hydrogen and step 6) chooses the reaction. Prepared compound It was obtained from step 5 with a) triethyl orthoformate b) NaBH4 to obtain N-methyl-11-phenyl-5H-dibenzo [b, e] [1, 4) Diasepene-5-propanamine with the formula where R to the power of 1 is hydrogen and R to the second power is methyl (1 claim, 0 figure).