TH19369Y - The composition of lipid nanoparticles encapsulating extract from Acmella oleracea and the method of preparing these particles. - Google Patents

Abstract

------15/11/2019------(OCR) Page 1 of 1 Abstract of Invention This invention aims to prepare lipid nanoparticle components for encapsulating extracts from the herb *Arundo donax* and the methods for preparing such particles. These particles can be prepared from two formulations: one containing only solid lipid compounds and another containing both solid and liquid lipid compounds working together to optimize application. Both formulations can enhance the efficiency of the extract, reduce the amount of substance used, and improve cell entry efficiency for the application of the nanoparticles, particularly in pharmaceuticals. One formulation of the invention, the composition for preparing lipid nanoparticles for encapsulating active ingredients, includes *Arundo donax* extract, solid lipid compounds, solvent, surfactant, and intermediate. Another formulation, also consisting of *Arundo donax* extract, solid lipid compounds, liquid lipid compounds, solvent, surfactant, and intermediate, is presented. ------------ Page 1 of 1 Abstract of Invention This invention aims to prepare lipid nanoparticle components for encapsulating extracts from *Arundo donax* and the methods for preparing such particles. These particles can enhance the efficiency of extracts, reduce the amount of active ingredient used, and improve cell entry efficiency. This facilitates the application of nanoparticles, particularly in pharmaceuticals. One form of invention for preparing lipid nanoparticles to encapsulate active ingredients consists of: A. Active ingredient (0.1-5% by weight of total components), B. Solid lipid compounds (0.1-2.5% by weight of total components), C. Solvent (0.5-60% by weight of total components), D. Surfactant (2-20% by weight of total components), and E. Medium (total volume 100% by weight of total components). A unique characteristic is that the active ingredient is an extract from *Amaranthus emblica*. Another form of invention for preparing lipid nanoparticles to encapsulate active ingredients is also presented. It consists of: A. Active ingredient, 0.1-5% by weight of total components; B. Solid fat compounds, 0.1-2.5% by weight of total components; C. Liquid fat compounds, 0.1-2.5% by weight of total components; D. Solvent, 0.5-60% by weight of total components; E. Surfactant, 2-20% by weight of total components; F. Medium, adjusted to a volume of 100% by weight of total components. Its specific characteristic is that the active ingredient mentioned above includes an extract from the ringworm plant.

Claims (10)

------15/11/2562------(OCR) Page 1 of 2 pages. Claims 1. The lipid nanoparticle composition encapsulating the extract of *Amaranthus emblica* consists of: a. *Amaranthus emblica* extract, 0.1-5% by weight of the total composition. b. Solid lipid compounds, 0.1-2.5% by weight of the total composition. c. Solvent, 0.5-60% by weight of the total composition. d. Surfactant, 2-20% by weight of the total composition. e. Medium, adjusted to a volume of 100% by weight of the total composition. 2. The lipid nanoparticle composition encapsulating the extract of *Amaranthus emblica* It consists of: a. Spilanthes extract, 0.1-5% by weight of total components; b. Solid lipid compounds, 0.1-2.5% by weight of total components; c. Liquid lipid compounds, 0.1-2.5% by weight of total components; d. Solvents, 0.5-60% by weight of total components; e. Surfactants, 2-20% by weight of total components; f. Medium, adjusted to a volume of 100% by weight of total components. 3. The lipid nanoparticle composition encapsulating the Spilanthes extract, as per claim 1 or 2, where the Spilanthes extract also contains the purified active ingredient in Spilanthes, spilanthol. 4. The lipid nanoparticle composition encapsulating the Spilanthes extract. According to claim 1 or 2, the solid lipid compound may be selected from cholesterol, lecithin, cetylpalmetate, phosphatidylcholine, cholesterol isosterate, steryl stearate, glyceryl monosterate, or a mixture of these substances. 5. The composition of the lipid nanoparticles encapsulating the extract of *Centella asiatica* according to claim 1 or 2, where the solvent may be selected from ethanol, ethyl acetate, methanol, dichloromethane, chloroform, or a mixture of these substances. Page 2 of 2. 6. The composition of the lipid nanoparticles encapsulating the extract of *Centella asiatica*. Under claim 1 or 2, the surfactant may be selected from any one of the following: poloxamer, polyoxyethylene (20), sorbitan monolaurate, polyoxyethylene (20), sorbitan monooleate, PEG-20 methyl glucose sesquistearate, PEG-75 lanolin, sorbitan monostearate, sorbitan monooleate, baremul-12, ceteth-20, or a mixture of the above.7. 7. Lipid nanoparticle composition encapsulating extract from Amaranthus emblica, according to claim 1 or 2, where the medium can be selected from tap water, mineral water, distilled water, deionized water, or a mixture of such substances. 8. Lipid nanoparticle composition encapsulating extract from Amaranthus emblica, according to claim 2, where the liquid lipid compound can be selected from vegetable oil, essential oil, or a mixture of such substances. 9. Lipid nanoparticle composition encapsulating extract from Amaranthus emblica, according to claim 8, where the liquid lipid compound can be selected from miglyol oil, grape seed oil, or a mixture of such substances. 10. Lipid nanoparticle composition encapsulating extract from Amaranthus emblica, according to claim 1 or 2, where the aforementioned components... Also includes additives of choice from preservatives, fragrances, colorings, scentings, either individually or in combination. ------------ Updated 10/05/2019 No claims ----------- Page 1 of 2 Claims 1. The components for preparing lipid nanoparticles for encapsulating active ingredients consist of: a. Active ingredient, 0.1-5% by weight of the total components; b. Solid lipid compounds, 0.1-2.5% by weight of the total components; c. Solvent, 0.5-60% by weight of the total components; d. Surfactant, 2-20% by weight of the total components; e. Medium, adjusted to a volume of 100% by weight of the total components. The specific characteristic of this medium is that the active ingredient includes an extract from *Amaranthus nasutus* (a type of weed). 2. The components for preparing lipid nanoparticles for encapsulating active ingredients consist of: a. Active ingredient, 0.1-5% by weight of the total components; b. Solid lipid compounds, 0.1-2.5% by weight of the total components; c. Liquid lipid compounds, 0.1-2.5% by weight of the total components; d. Solvent, 0.5-60% by weight of the total components; e. Surfactant, 2-20% by weight of the total components; f. Medium, adjusted to a volume of 100% by weight of the total components. The specific characteristics of this medium include the active ingredient, which is an extract from *Centella asiatica* (a type of weed). 3. Nanoparticle composition as per claim 1 or 2, whereby the active ingredient also includes the pure active ingredient in spiranthol (a type of herb). 4. Nanoparticle composition as per claim 1 or 2, where the solid lipid compound may be selected from cholesterol, lecithin, cetylpalmetate, phosphatidylcholine, cholesterol isosterate, steryl stearate, glyceryl monosterate, either individually or in a mixture of these substances. 5. Nanoparticle composition as per claim 1 or 2, where the solvent may be selected from ethanol, ethyl acetate, methanol, dichloromethane, chloroform, or a mixture of these substances. (Page 2 of 2) 6. Nanoparticle composition as per claim 1 or 2, where the surfactant may be selected from any one of the following: poloxamer, polyoxyethylene (20) sorbitan monolaurate, polyoxyethylene (20) sorbitan monooleate, PEG-20 methyl glucose sesquistearate, PEG-75 lanolin, sorbitan monostearate, sorbitan monooleate, baremul-12, or ceteth-20. Or a mixture of such substances. 7. Nanoparticle composition as per claim 1 or 2, where the intermediate substance can be selected from tap water, mineral water, distilled water, deionized water, or a mixture of such substances. 8. Nanoparticle composition as per claim 2, whereby the liquid lipid compound may be selected from either vegetable oil or essential oil, or a mixture of such oils. 9. Nanoparticle composition as per claim 8, whereby the liquid lipid compound may be selected from either miglyol oil or grape seed oil, or a mixture of such oils. 10. Nanoparticle composition as per claim 1 or 2, whereby such composition may also include an additive of choice from preservatives, fragrances, colorings, scentings, either individually or in combination.