TH19369C3 - The lipid nanoparticle composition of the extract from the ring rake (Acmellaoleracea) and the preparation of such particles were carried out. - Google Patents

Abstract

Invention Summary, which will appear on the advertisement page ReadFile:------15/11/2019------(OCR)Page 1 of 1 Page Invention Summary This invention focuses on Preparation of lipid nanoparticles, rake extract, and the preparation of such particles, such particles can be prepared from two composition formulas, both the solid fat-only component and the whole-lipid compound. The solid and liquid lipids work together to optimize the application. The two component formulations can effectively reduce the amount of substance used in the extract and increase the efficiency of cell entry for nanoparticle adoption. Specifically used in pharmaceutical applications, as one of the fabricated forms of compositions for the preparation of lipid nanoparticles, active binders include ring rake vegetable extracts, solid lipid compounds, solvents, surfactants and Intermediates in another form of fabrication composition for the preparation of lipid nanoparticles, binding active substances include ring rake vegetable extracts, solid lipid compounds, liquid lipid compounds, solvents, surfactants and reagents. Middle--------------- Page 1 of the number 1 Page Summary of Invention This invention focuses on the preparation of lipid nanoparticles containing extracts from the ring rake extract and the process of preparing such particles. Improved utilization of substances and their efficiency in entering cells for nanoparticle applications, especially in pharmaceutical applications, is one of the fabricated compositions for the preparation of lipid-retaining nanoparticles as an integral compound. with a. 0.1-5 % by weight of total constituents b. solid fat compound 0.1-2.5% by weight of total constituents c. 0.5-60% by weight of total constituents D. 2-20% by weight of all surfactants by weight of all constituents E. Intermediates adjust the volume to 100 by weight of all constituents, which is characterized by the fact that such important active substances consist of extracts. From ring rake vegetables in another form of composition for the preparation of lipid nanoparticles, it contains 0.1-5% by weight of the total content of g. 0.1-2.5 percent by water weight of all constituents c. liquid fat compound 0.1-2.5% by weight of all constituents d. solvent 0.5-60% by weight of total constituents E. surfactant amount 2% -20 by weight of all constituents f. The medium was adjusted to reach 100 by weight of all constituents, which is characterized by the fact that such important substances consisted of extracts from ringworm vegetables.

Claims (9)

Claims (all) which will not appear on the advertisement page:------11/15/2019------(OCR)Page 1 of the 2 claim pages. 1. Fat-retaining nanoparticle constituents of vegetable harrow extract include: a. vegetable harrow extract 0.1-5% by weight of total constituents b. solid fat compounds 0.1-2.5% by weight of Total composition C. Solvent 0.5-60% by weight of the total composition D. Surfactant 2-20% by weight of the total composition e. Intermediates adjust the volume to 100 by weight of the total composition. 2. Components of fat-retaining nanoparticles of rake extract include: a. 0.1-5% by weight of rake vegetable extract b. solid fat compounds 0.1-2.5% by weight of Total components C. Liquid fat compounds 0.1-2.5% by weight of total components D. Solvents 0.5-60% by weight of total components E. Surfactants 2-20% by weight of All constituents f. Intermediates volume adjusted to 100 by weight of all constituents. 3. The lipid nanoparticle constituents of the Chinese knotweed extract according to Claim 1 or 2, where the Chinese knotweed extract also contains the pure active ingredient spilanthol. 4. The lipid entrapment nanoparticle constituents of the rhubarb extract according to Claim 1 or 2, where solid lipid compounds were selected from cholesterol, lecithin, cetyl palmate ( cetylpalmetate, phosphatidylcholine, cholesterol isostearate, sterylstearate, glyceryl monostearate ( glycerylmonosterate), either or a mixture thereof. 5. The lipid nanoparticle constituents of the rhubarb extract according to Claim 1 or 2, where the solvent was selected from ethanol, ethylacetate, and ethanol. methanol, dichloromethane, chloroform, either or a mixture thereof 6. The lipid-retaining nanoparticle constituents of rake extract according to Claim No. 1 or 2, where the surfactant was selected from poloxamer, polyoxyethyl. Lean(20)sorbitan monolaurate(polyoxyethylene(20)sorbitanmonolaurate),polyoxyethylene(20)sorbitan monooleate(polyoxyethylene(20)sorbitanmonooleate)PE G-20methylglucosesesquistearate (PEG-20methylglucosesesquistearate)PEG-75lanolin (PEG-75lanolin)sorbitan monostearate (sorbitan monostearate)sorbitan monoolea or a mixture thereof 7. The lipid-retaining nanoparticle constituents of vegetable harrow extract according to Claim No. 1 or 2, where the intermediates can be chosen either from tap water, mineral water, distilled water, deionized water, or a mixture of the substances. such 8. The lipid nanoparticle constituents retain extracts from the vegetable harrow according to claim 2, where the liquid lipid compounds can be selected from vegetable oils, essential oils, or a mixture of them. say 9. The lipid nanoparticle constituents retained the vegetable rake extract according to Claim No. 8, where the liquid lipid compounds were selected from miglyol, grapeseed oil, either or their mixtures. of such substances1 0. The lipid-retaining nanoparticle constituents of the cultivar extract according to Claim 1 or 2, where the constituents are also supplemented with selective additives from preservatives, fragrances, coloring agents, flavoring agents such as either or a mixture of such substances------------Edit 10/05/2019No claim-----------Page 1 of 2 clauses hold the right 1. Ingredients for the preparation of lipid encapsulating nanoparticles: a. Active substances 0.1-5% by weight of total components B. Solid fat compounds 0.1-2.5% by weight of total components C. Agents Dissolve 0.5-60 percent by weight of all components D. Surfactant 2-20 percent by weight of all components E. Intermediates adjust the volume to reach 100 by weight of all components, which is characterized by the substance Such essential components include extracts from the vegetable rake. 2. Ingredients for the preparation of lipid nanoparticles encapsulating active substances consisted of a. active ingredients 0.1-5% by weight of total components b. solid fat compounds 0.1-2.5% by weight of total components c. fat compounds Liquid 0.1-2.5% by weight of all components d. Solvent 0.5-60% by weight of all components E. Surfactant 2-20% by weight of all components f. Intermediates Adjust the volume to 100 by weight of all constituents, which is characterized by that the active ingredient contains extracts from rake. 3. nanoparticle constituents according to claims 1 or 2 where the active ingredient also contains pure active ingredients in spilanthol; 4. nanoparticle constituents according to claims 1 or 2, where solid fat compounds can be selected from cholesterol, lecithin, cetylpalmetate, phosphatidylcholine, and cholesterol iso stearate (cholesterolisosterate), sterylstearate, glyceryl monostearate (glycerylmonosterate), or a mixture thereof. 5. The nanoparticle composition according to claims 1 or 2 where the solvent can be chosen from ethanol, ethylacetate, methanol, dichloromethane (dichloromethane), chloroform (chloroform), either or a mixture of such substances, page 2 of 2 6. Nanoparticle composition according to Claim 1 or 2, where surfactants are selected from poloxamer, polyoxyethylene (20) sorbi. Tenmonolaluate (polyoxyethylene(20)sorbitanmonolaurate), polyoxyethylene(20)sorbitanmonooleate (polyoxyethylene(20)sorbitanmonolaurate), poj-20methyl PEG-20methylglucosesesquistearate, PEG-75 lenolin, sorbitan monostearate, sorbitan monoole eth (sorbitan monooleate), baremul-12 (baremul-12), cateth-20 (ceteth-20), or their mixtures 7. Nanoparticle constituents according to claims 1 or 2, provided that the intermediate is either selected from tap water, mineral water, distilled water, deionized water, or a mixture thereof. 8. Nanoparticle composition according to Claim 2, whereby the liquid lipid compound is selected from either vegetable oil, essential oil or a mixture thereof. 9. Nanoparticle constituents as per claim 8, provided that the liquid lipid compound is selected from either miglyol, grapeseed oil or a mixture thereof. 0. Nanoparticle constituents according to Claims 1 or 2, where such constituents also include selective additives of preservatives, fragrances, coloring agents, flavoring agents, either or a mixture. of such substances