TH18004Y - A gel formula made from Centella asiatica extract for relieving rashes, itching, inflammation, pain, and swelling, along with the manufacturing process. - Google Patents

Abstract

Page 1 of 1. Summary of the Invention: The gel film containing Phaya Yor extract has a Phaya Yor leaf extract as the main active ingredient (2.5-5%) and also includes gelling agents, film-forming agents, solubilizers, dispersing agents, antioxidants, pH adjusters, and preservatives. The production process of the Phaya Yor extract gel film consists of the following steps: 1) Preparation of the Phaya Yor leaf extract; 2) Preparation of the Phaya Yor extract gel film. The objective of this invention is to develop a gel film product from Thai herbs using a simple preparation method. It adheres to the desired area for a longer period compared to traditional semi-solid/semi-liquid topical medications. When applied, the gel film forms a thin, flexible film on the affected skin. It can be easily peeled off without rinsing and does not stain clothing. It is suitable for individuals with skin allergies, relieving itching, inflammation, pain, and swelling from insect bites. This reduces the need for conventional medications that may have high side effects and adds value to Thai herbs for international recognition.

Claims (3)

------16/10/2563------(OCR) 1. Gel formulation from Centella asiatica extract for the relief of rashes, itching, inflammation, pain, and swelling, consisting of: gelling agent 0.5-20% by weight; dispersing agent 0.5-20% by weight; solubilizing agent 1.0-40% by weight; Centella asiatica leaf extract 2.5-5% by weight; antioxidant 0.005-3% by weight; preservative 0.005-3% by weight; pH adjuster 0.005-3% by weight; water 5-80% by weight. 2. Gel formulation from Centella asiatica extract for the relief of rashes, itching, inflammation, pain, and swelling, as per claim 1, which includes an additional film-forming agent of 0.5-10% by weight. 3. A gel formulation from Centella asiatica extract for the relief of rashes, itching, inflammation, pain, and swelling, as per Patent 1 or 2, where the gelling agent can be selected from hydroxypropyl ethylcellulose, hydroxypropyl methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl cellulose, carbopol, poloxamer, or sodium alginate, either individually or in combination. 4. A gel formulation from Centella asiatica extract for the relief of rashes, itching, inflammation, pain, and swelling, as per Patent 1-3, where the film-forming agent can be selected from... 5. A gel formulation from Centella asiatica extract for the relief of rashes, itching, inflammation, pain, and swelling, according to any one of the claims 1-4, where the dispersing agent can be selected from glycerin, propylene glycol, polyethylene glycol, or a mixture of these substances. 6. A gel formulation from Centella asiatica extract for the relief of rashes, itching, inflammation, pain, and swelling, according to any one of the claims 1-5, where the dissolving agent can be selected from glycerin, propylene glycol, polyethylene glycol, sorbitol, ethanol, or a mixture of these substances. 7. A gel formulation from Centella asiatica extract for the relief of rashes, itching, inflammation, pain, and swelling, in accordance with any one of the patents 1-6, where the antioxidant can be selected from disodium EDTA, tetrasodium EDTA, butylated hydroxytoluene, or butylated hydroxyanisole, or a combination of these substances. 8. A gel formulation from Centella asiatica extract for the relief of rashes, itching, inflammation, pain, and swelling, in accordance with any one of the patents 1-7, where the preservative can be selected from methyl paraben, propyl paraben, sodium benzoate, or phenoxyethanol, or a combination of these substances. 9. The gel formula from Phaya Yor extract for relieving rashes, itching, inflammation, pain, and swelling, according to any one of the patents 1-8, where the pH adjuster can be selected from citric acid, sodium hydroxide, potassium hydroxide, or triethanolamine, or a mixture of these substances. 10. The manufacturing process of the gel formula from Phaya Yor extract for relieving rashes, itching, inflammation, pain, and swelling, which contains components according to any one of the patents 1-9, has the following steps: A. Preparation of Phaya Yor leaf extract: 1. Dried Phaya Yor leaves are used from Phaya Yor trees that are 3 months old. They are washed with clean water to remove impurities, air-dried, and ground to reduce their size. 2. The dried Phaya Yor leaves are extracted with 70-95% ethyl alcohol in the ratio of Phaya Yor leaves... 1. Dry solution to alcohol at a ratio of 1:4. Soak for 5-10 days, shaking in the morning and evening. 3. Filter the resulting solution using a vacuum pump with filter paper. 4. Evaporate the solvent using a rotary evaporator at 50°C to obtain the crude extract from the leaves. B. Preparation of the gel film formulation: 1. Mix the gelling agent and film-forming agent in the dispersing agent and water according to the specified ratio. 2. Mix the leaf extract, dissolving agent, and antioxidant. 2. Mix the gel film base from step 1 and the solution from step 2 thoroughly in a mortar until homogeneous. Adjust the pH of the gel film formulation using a pH adjuster until it reaches an appropriate pH of 4.5-6.5, then package it in tubes. ------------ Revised November 2, 2018. Claims: 1. The gel formula from the extract of *Phyllanthus emblica* for relieving rashes, itching, inflammation, pain, and swelling consists of: Gelling agent 0.5-20% by weight; Dispersing agent 0.5-20% by weight; Solvent 1.0-40% by weight; *Phyllanthus emblica* leaf extract 2.5-5% by weight; Antioxidant 0.005-3% by weight; Preservative 0.005-3% by weight; pH adjuster 0.005-3% by weight; Water 5-80% by weight. ++++++++++++++++++++++ Page 1 of 2 pages. Claims. 1. A gel formula derived from Centella asiatica extract for relieving itching, inflammation, pain, and swelling contains: gelling agent (0.5-20% by weight), dispersing agent (0.5-20% by weight), solubilizer (1.0-40% by weight), Centella asiatica leaf extract (2.5-5% by weight), antioxidant (0.005-3% by weight), preservative (0.005-3% by weight), pH adjuster (0.005-3% by weight), and water (5-80% by weight). 2. A gel formulation from the extract of *Phyllanthus emblica* for the relief of rashes, itching, inflammation, pain, and swelling, as per Patent 1, which shall be further composed of a film-forming agent of 0.5-10% by weight. 3. A gel formulation from the extract of *Phyllanthus emblica* for the relief of rashes, itching, inflammation, pain, and swelling, as per Patent 1 or 2, where the gelling agent may be selected from hydroxypropyl ethylcellulose, hydroxypropyl methylcellulose, sodium carboxymethyl cellulose, or hydroxypropyl cellulose. (hydroxypropyl cellulose), carbopol, poloxamer, sodium alginate, or a mixture of these substances. 4. A gel formulation from the extract of *Phyllanthus emblica* for the relief of rashes, itching, inflammation, pain, and swelling, according to any one of the claims 1-3, where the film-forming agent can be selected from polyvinyl alcohol, polyvinyl pyrrolidone, or a mixture of these substances. 5. A gel formulation from the extract of *Phyllanthus emblica* for the relief of rashes, itching, inflammation, pain, and swelling, according to any one of the claims 1-4, where the dispersing agent can be selected from glycerin, propylene glycol, or polyethylene glycol. (polyethylene glycol) either individually or in combination. 6. A gel formulation from the extract of *Phyllanthus emblica* for the relief of rashes, itching, inflammation, pain, and swelling according to any one of the claims 1-5, where the solvent can be selected from glycerin, propylene glycol, polyethylene glycol, sorbitol, ethanol, either individually or in combination. 7. A gel formulation from the extract of *Phyllanthus emblica* for the relief of rashes, itching, inflammation, pain, and swelling according to any one of the claims 1-6, where the antioxidant can be selected from... Disodium EDTA, tetrasodium EDTA, butylated hydroxytoluene, butylated hydroxyanisole, or a mixture of these substances. 8. A gel formulation from Phaya Yor extract for the relief of rashes, inflammation, pain, and swelling, according to any one of the claims 1-7, where the preservative can be selected from methyl paraben, propyl paraben, sodium benzoate, phenoxyethanol, or a mixture of these substances. 9. A gel formulation from Phaya Yor extract for the relief of rashes, inflammation, pain, and swelling, according to any one of the claims 1-8, where the pH adjuster... The aforementioned substances can be selected from citric acid, sodium hydroxide, potassium hydroxide, or triethanolamine, either individually or in combination. 10. The process for producing a gel formula from the extract of *Phyllanthus emblica* for relieving rashes, inflammation, pain, and swelling, which contains any one of the components according to claims 1-9, involves the following steps: A. Preparation of the *Phyllanthus emblica* leaf extract: 1. Dried *Phyllanthus emblica* leaves are used from *Phyllanthus emblica* trees older than 3 months. They are washed with clean water to remove impurities, air-dried, and ground to reduce their size. 2. The dried *Phyllanthus emblica* leaves are extracted with 70-95% ethyl alcohol in a ratio of dried *Phyllanthus emblica* leaves to alcohol of 1:4. The mixture is macerated for 5-10 days, shaking morning and evening. 3. The resulting solution is filtered using a vacuum pump with filter paper. 4. Evaporate the solvent using a rotary evaporator at a temperature not exceeding 50 degrees Celsius until a crude extract from the leaves of *Phyllanthus emblica* is obtained. b. Preparation of the gel film formulation consists of: 1. Dispersing the gelling agent and film-forming agent in the dispersing agent and mixing thoroughly according to the specified ratio. 2. Mixing the *Phyllanthus emblica* leaf extract, dissolving agent, antioxidant, and preservative thoroughly according to the specified ratio. 3. Gradually mix the gel film base obtained in step 1 and the solution in step 2 in a mortar until homogeneous. Adjust the pH of the gel film formulation using a pH adjuster until it reaches an appropriate pH of approximately 4.5-6.5, then package it into tubes.