TH18004C3 - Gel formula from Phaya Yo extract for relieving rash, itching, swelling, pain and production process. - Google Patents

Abstract

Summary of the invention which will appear on the advertisement page ReadFile:Page 1 of the 1 page Summary of the invention of the gel film, Phaya Yo extract contains extracts from Phaya Yo leaves as an active ingredient (2.5-5%). And it consists of gelling agent, film forming agent, dispersant, dispersant, anti-oxidant, pH adjuster, preservative. The process of producing gel film, Phaya Yo extract consists of the following steps. This invention aims to develop a gel film product from Thai herbs with a simple preparation process that can adhere to the desired area longer than when applied. Compared to the traditional semi-solid-semi-liquid form of external use, when applying gel-film, it forms a thin flexible film that coats the skin in the affected area. It can be easily peeled off without Must wash off, do not stain the clothes, suitable for people with systemic problems with skin allergies by relieving rashes, itching, swelling from insect bites, reducing the use of modern drugs that may have high side effects and create added value for Thai herbs to be accepted internationally

Claims (4)

Claims (all) which will not appear on advertisement pages:------16/10/2563------(OCR) 1. Gel formula from Phaya Yo extract for relief. Rash, itching, inflammation, pain, swelling consisted of gelling agent 0.5-20% by weight, dispersing agent 0.5-20% by weight dispersant, 1.0-40% by weight, extract from Phaya Yo Roi leaves. 2.5-5 by weight of anti-oxidation agent 0.005-3 by weight of preservative, 0.005-3 by weight of pH adjuster, 0.005-3 by weight of 5-80 percent by water. by weight 2. Gel formula from Phaya Yo extract for relieving rash, itching, inflammation, pain, swelling according to claim 1, which is additionally composed of 0.5-10% by weight film-forming agent. 3. Gel formula from Phaya Yo extract for relieving rash, itching, swelling, according to claim 1 or 2, where the gelling agent can be selected from hydroxypropylethylcellulose. hydroxypropylmethylcellulose (hydroxypropylmethylcellulose) sodium carboxymethylcellulose (sodiumcarboxymethylcellulose) hydroxypropylcellulose (carbopol) poloxamer ( poloxamer, sodium alginate, either or a combination thereof 4. Gel formula from Phaya Yo extract for relieving rashes, itching, swelling, according to claims 1-3, where the film-forming agent is selected from polyvinyl alcohol (polyvinylalchohol). polyvinylpyrrolidone or a combination thereof 5. Gel formula from Phaya Yo extract for relieving rash, itching, swelling, pain, swelling according to claims 1-4, one of which the dispersant can be selected from glycerin (glycerin) Po. Propylene glycol (propylenegylcol) polyethylene glycol (polyethyleneglycol) or a combination thereof. 6. Gel formula from Phaya Yo extract for relieving rash, itching, swelling, pain, swelling according to claims 1-5, one of which the solution is selected from glycerin (glycerin) propyl. Lean glycol (propylenegylcol), polyethylene glycol (polyethyleneglycol), sorbitol (sorbitol), ethanol (ethanol), either or a combination thereof. 7. Gel formula from Phaya Yo extract for relieving rash, itching, swelling, according to claim 1-6, where the anti-oxidant is selected from EDTA disodium EDTA. EDTA, tetrasodiumEDTA, butylatedhydroxytoluene, butylatedhydroxytoluene, butylatedhydroxyanisole, or a mixture thereof together 8. Gel formula from Phaya Yo extract for relieving rash, itching, swelling, pain, swelling according to claim 1-7, where such preservative is selected from methylparaben (methylparaben), propyl. Parabens (propylparaben), sodium benzoate (sodiumbenzoate), phenoxyethanol (phenoxyethanol), either or a combination thereof. 9. Gel formula from Phaya Yo extract for relieving rash, itching, swelling, pain, swelling according to claim 1-8, where the aforementioned pH adjuster can be selected from citric acid ( citricacid, sodium hydroxide (sodiumhydroxide), potassium hydroxide (potassiumhydroxide), triethanolamine (triethanolamine), or a combination thereof1 0. The production process of gel formula from Phaya Yo extract for relieving rash, itching, swelling, which contains any of the components according to claim 1-9, has the following steps: A. Preparation of leaf extracts Phaya Yo 1. Dried Phaya Yo leaves will use Phaya Yo leaves from Phaya Yo plants that are 3 months old to be washed with clean water to get rid of foreign objects, to be dried and crushed to reduce the size. 2. The dried Phaya Yo leaves were extracted with 70-95% of ethyl alcohol in the ratio of dried Phaya Yo leaves to alcohol equal to 1 to 4, fermented for 5-10 days, shaken at the entrance and in the evening. 3. Take the solution that has been filtered with a vacuum pump (vacuumpump) using filter paper. 4. Evaporate the solvent with a rotary evaporator at a temperature of 50°C. The crude extract is obtained from the leaves of Phaya Yok. The preparation of the gel film formulation consists of 1. Mix the gelling agent and dispersing film-forming agent in the dispersant and water according to the specified ratio. 2. Mixing Phaya Yo leaf extract, anti-oxidative solubility and waste substances, mix together according to the specified ratio. 3. Take the gel film base obtained in item 1 and the solution in item 2, gradually mix in a mixing bowl until homogeneous, adjust the acidity - alkalinity of the gel film formulation by using a pH adjuster. The gel film formulation has an appropriate pH of 4.5-6.5 and is then packaged in a tube-like packaging. 1. Gel formula from Phaya Yo extract for relieving rash, itching, swelling, pain, swelling, contains gelling agent 0.5-20% by weight, dispersant 0.5-20% by weight, dispersant 1.0-40%. By weight, Phaya Yo leaf extract 2.5-5% by weight, antioxidant 0.005-3% by weight, preservative 0.005-3% by weight, pH adjuster 0.005-3% by weight. Water 5-80% by weight++++++++++++++++++++++++ Page 1 of 2 pages Claims 1. Gel formula from Phaya Yo extract. For relieving rash, itching, inflammation, swelling, it contains 0.5-20% by weight gelling agent, 0.5-20% by weight dispersant, 1.0-40% by weight dispersant, and Phaya Yo leaf extract. 2.5-5 by weight Antioxidant 0.005-3 by weight Preservative 0.005-3 by weight pH Adjuster 0.005-3 by weight Water 5-80% by weight 2.Formula Gel from Phaya Yo extract for relieving rash, itching, inflammation, pain, swelling according to claim 1 where Additional composition with film forming agent 0.5-10 by weight3. Gel formula from Phaya Yo extract for relieving rash, itching, inflammation, pain, swelling according to the 1st or 2nd claim. The gelling agent is selected from hydroxypropylmethylcellulose, hydroxypropylethylcellulose, hydroxypropylmethylcellulose, sodium carboxymethylcellulose. (sodiumcarboxymethylcellulose) hydroxypropylcellulose (hydroxypropylcellulose) carbo one of pol (carbopol), poloxamer, sodium alginate or a mixture of such substances4. Gel formula from Phaya Yo extract for relieving rash, itching, inflammation, pain, swelling according to the 1-3 claims. One where such film-forming agents can be chosen from polyvinyl alcohol (polyvinylalchohol). Pyrolidone (polyvinylpyrrolidone) either or a combination thereof5. Gel formula from Phaya Yo extract for relieving rash, itching, inflammation, pain, swelling according to claims 1-4. One of these dispersants is glycerin (glycerin), propylene glycol. (propylenegylcol), polyethylene glycol (polyethyleneglycol), either or a combination of the above. 6. Gel formula from Phaya Yo extract for relieving rash, itching, swelling, according to claim No. 1 -5 Which of the following? One where such solutions are selected from glycerin (glycerin), propylene glycol (propylene). gylcol), polyethylene glycol (polyethyleneglycol), sorbitol (sorbitol), ethanol (ethanol) either or a mixture of the aforementioned substances7. Gel formula from Phaya Yo extract for relieving rash, itching, inflammation, pain, swelling according to claims 1-6. One where such antioxidants are selected from EDTA disodium EDTA. Page 2 of the number 2 pages Sodium (tetrasodiumEDTA) butylated hydroxytoluene (butylatedhydroxytoluene) butylate hydroxyanisole (butylatedhydroxyanisole) either or a combination thereof8. Gel formula from Phaya Yo extract for relieving rash, inflammation, pain, swelling according to claims 1-7. One such preservative is chosen from methylparaben, propyl paraben. paraben), sodium benzoate (sodiumbenzoate), phenoxyethanol (phenoxyethanol) in any way one or the aforementioned substances mixed together9. Gel formula from Phaya Yolam extract for relieving rash, inflammation, pain, swelling according to claim 1-8. One where such pH adjusters are selected from citricacid, sodium hydroxyl. oxide (sodiumhydroxide), potassium hydroxide (potassiumhydroxide), triethanolamine (triethanolamine) either or a mixture of such substances10. Method for producing gel formula from Phaya Yo Lam extract for relieving rash, inflammation, pain and swelling where there is The components of claims 1-9 are as follows: A. Preparation of extracts from Phaya Yo leaves 1. Dried Phaya Yo leaves will use Phaya Yo leaves from Phaya Yo trees that are more than 3 months old to be washed with water. Cleaned to remove foreign matter, dried and crushed to reduce the size. 2. The dried Phaya Yo leaves were extracted with 70-95% of ethyl alcohol in the ratio of Phaya leaves. Dry yoghurt per alcohol equal to 1 to 4 fermented for 5-10 days, shake in the morning-evening. 3. Take the solution that has been filtered with a vacuum pump (vacuumpump) using filter paper. 4. Evaporate the solvent with a rotary evaporator at no temperature. more than 50 degrees Celsius until obtaining rough extracts from Phaya Yo leaves b. Preparation of gel film formulation consists of 1. Take the gelling agent and dispersing film-forming agent in the dispersant and mix well accordingly. Nominal ratio 2. Make fruit extracts from Phaya Yo leaves, dissolve substances, anti-oxidants and preservatives to mix. matched according to the specified ratio. 3. Take the gel film base obtained in step 1 and the solution in step 2, gradually pouring them together in a mortar, mixing the drug until it is Homogeneous adjustment of pH of gel film formulation by using pH adjuster The gel film formulation has an optimum pH of approx. 4.5-6.5 and then packed in tube packaging.