TH178096A - Transformation of human embryonic stem cells into endocrine cells. Of the pancreas using a HB9 regulator - Google Patents
Transformation of human embryonic stem cells into endocrine cells. Of the pancreas using a HB9 regulatorInfo
- Publication number
- TH178096A TH178096A TH1501003785A TH1501003785A TH178096A TH 178096 A TH178096 A TH 178096A TH 1501003785 A TH1501003785 A TH 1501003785A TH 1501003785 A TH1501003785 A TH 1501003785A TH 178096 A TH178096 A TH 178096A
- Authority
- TH
- Thailand
- Prior art keywords
- cells
- stage
- transformation
- stem cells
- pancreas
- Prior art date
Links
- 230000001131 transforming Effects 0.000 title claims abstract 3
- 210000000496 Pancreas Anatomy 0.000 title claims 2
- 210000003890 endocrine cells Anatomy 0.000 title claims 2
- 210000001671 Embryonic Stem Cells Anatomy 0.000 title 1
- 238000004113 cell culture Methods 0.000 claims abstract 5
- 101710030334 ATHB-9 Proteins 0.000 claims abstract 4
- 102100017977 MNX1 Human genes 0.000 claims abstract 4
- 101700072663 MNX1 Proteins 0.000 claims abstract 4
- 102100015783 NKX6-2 Human genes 0.000 claims abstract 4
- 101710012719 NKX6-2 Proteins 0.000 claims abstract 4
- 101710014878 PDHX Proteins 0.000 claims abstract 4
- 102100017571 PDX1 Human genes 0.000 claims abstract 4
- 101700077314 PDX1 Proteins 0.000 claims abstract 4
- 229940036555 Thyroid hormones Drugs 0.000 claims abstract 4
- 210000004039 endoderm cell Anatomy 0.000 claims abstract 4
- 239000003112 inhibitor Substances 0.000 claims abstract 4
- 230000002401 inhibitory effect Effects 0.000 claims abstract 4
- 210000001778 pluripotent stem cell Anatomy 0.000 claims abstract 4
- 239000005495 thyroid hormone Substances 0.000 claims abstract 4
- 210000004027 cells Anatomy 0.000 claims abstract 3
- 238000004519 manufacturing process Methods 0.000 claims 1
Abstract
แก้ไขบทสรุปการประดิษฐ์ 11/9/2558 การประดิษฐ์นี้จัดให้มีวิธีการส่งเสริมการทำให้เซลล์ต้นกำเนิดพลูริโพเทนต์เจริญเปลี่ยนรูป ไปเป็นเซลล์เอนโดเดิร์มของตับอ่อนที่แสดงออก PDX1, NKX6.1 และ HB9 โดยเฉพาะอย่างยิ่ง วิธีการครอบคลุมถึงการเพาะเลี้ยงเซลล์ระยะ 4 ถึงระยะ 6 ด้วยฮอร์โมนของต่อมไธรอยด์ (เช่น T3), สารยับยั้ง ALK5 หรือทั้งสองอย่าง ----------------------------------------------------------------------------- คำขอใหม่ปรับปรุงวันที่ 12/04/2559 การประดิษฐ์นี้จัดให้มีวิธีการส่งเสริมการทำให้เซลล์ต้นกำเนิดพลูริโพเทนต์เจริญเปลี่ยนรูปไป เป็นเซลล์เอนโดเดิร์มของตับอ่อนที่แสดงออก PDX1, NKX6.1 และ HB9 โดยเฉพาะอย่างยิ่งวิธีการ ครอบคลุมถึงการเพาะเลี้ยงเซลล์ระยะ 4 ถึงระยะ 6 ด้วยฮอร์โมนของต่อมไธรอยด์ (เช่น T3), สารยับยั้ง ALK5 หรือทั้งสองอย่าง Edit Summary of Invention 11/9/2015 This invention provides a method to promote the transformation of pluripotent stem cells. To pancreatic endoderm cells that express PDX1, NKX6.1 and HB9. The methods cover the 4th to stage 6 cell culture with thyroid hormones (eg T3), ALK5 inhibitors or both. -------------------------------------------------- --------------------------- New Request Updated 12/04/2016 This invention provides a way to promote the cell reproduction. Pluripotent was born and transformed. It is the pancreatic endoderm cells that express PDX1, NKX6.1 and HB9. Stage IV to Stage 6 cell cultures are covered with thyroid hormones (eg T3), ALK5 inhibitors or both.
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TH178096A true TH178096A (en) | 2018-07-19 |
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