TH148730B - The conversion of stem cells from human embryos to cells that perform specific functions. - Google Patents
The conversion of stem cells from human embryos to cells that perform specific functions.Info
- Publication number
- TH148730B TH148730B TH1201003054A TH1201003054A TH148730B TH 148730 B TH148730 B TH 148730B TH 1201003054 A TH1201003054 A TH 1201003054A TH 1201003054 A TH1201003054 A TH 1201003054A TH 148730 B TH148730 B TH 148730B
- Authority
- TH
- Thailand
- Prior art keywords
- cells
- conversion
- specific functions
- perform specific
- stem cells
- Prior art date
Links
- 210000004027 cells Anatomy 0.000 title abstract 4
- 238000006243 chemical reaction Methods 0.000 title 1
- 210000002257 embryonic structures Anatomy 0.000 title 1
- 210000000130 stem cell Anatomy 0.000 title 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims abstract 6
- 102000004877 Insulin Human genes 0.000 claims abstract 3
- 108090001061 Insulin Proteins 0.000 claims abstract 3
- 102100015783 NKX6-2 Human genes 0.000 claims abstract 3
- 101710012719 NKX6-2 Proteins 0.000 claims abstract 3
- 210000003372 Endocrine Glands Anatomy 0.000 claims abstract 2
- 229960004666 Glucagon Drugs 0.000 claims abstract 2
- 108060003199 Glucagon Proteins 0.000 claims abstract 2
- MASNOZXLGMXCHN-ZLPAWPGGSA-N Glucagonum Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims abstract 2
- 239000003550 marker Substances 0.000 claims 1
- 210000000277 Pancreatic Ducts Anatomy 0.000 abstract 1
- 210000001778 pluripotent stem cell Anatomy 0.000 abstract 1
- 230000001131 transforming Effects 0.000 abstract 1
Abstract
การประดิษฐ์นี้จัดเสนอวิธีการที่จะส่งเสริมให้สเต็มเซลล์ซึ่งมีคุณสมบัติเป็นพลูริโพเทนต์เกิด การเปลี่ยแปลงและพัฒนาไปสู่เซลล์ที่ผลิตอินซูลินโดยเฉพาะอย่างยิ่งการประดิษฐ์นี้จัดเสนอววิธีการ ที่จะผลิตเซลล์ซึ่งการแสดงออกของตัวบ่งชี้อันเป็นลักษณะเฉพาะของเซลล์ที่สืบเชื้อสายมาจากต่อมไร้ ท่อของตับอ่อนซึ่งมีการแสดงออกทั้ง NKX6.1 และอินซุลินร่วมกันรวมทั้งกลูคากอนในปริมาณน้อยที่สุด ร่วมกัน The invention proposed a method to promote the birth of pluripotent stem cells. Transformation and development into insulin-producing cells. In particular, this invention provides a method for To produce cells that express a characteristic identifier of cells that descend from the endocrine glands. Pancreatic ducts, with common expression of NKX6.1 and insulin, as well as the least common amounts of glucagon
Claims (2)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH1201003054A TH1201003054A (en) | |
| TH148730B true TH148730B (en) | 2016-04-18 |
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