TH133352B - The conversion of stem cells from human embryos to cells that perform specific functions. - Google Patents
The conversion of stem cells from human embryos to cells that perform specific functions.Info
- Publication number
- TH133352B TH133352B TH1201003055A TH1201003055A TH133352B TH 133352 B TH133352 B TH 133352B TH 1201003055 A TH1201003055 A TH 1201003055A TH 1201003055 A TH1201003055 A TH 1201003055A TH 133352 B TH133352 B TH 133352B
- Authority
- TH
- Thailand
- Prior art keywords
- cells
- expression
- conversion
- stem cells
- specific functions
- Prior art date
Links
- 210000004027 cells Anatomy 0.000 title claims abstract 9
- 238000006243 chemical reaction Methods 0.000 title claims 2
- 210000000130 stem cell Anatomy 0.000 title abstract 2
- 210000002257 embryonic structures Anatomy 0.000 title 1
- 210000003372 Endocrine Glands Anatomy 0.000 claims abstract 2
- 102100018315 NEUROG3 Human genes 0.000 claims abstract 2
- 101710022625 NEUROG3 Proteins 0.000 claims abstract 2
- 102100015783 NKX6-2 Human genes 0.000 claims abstract 2
- 101710012719 NKX6-2 Proteins 0.000 claims abstract 2
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 2
- 210000001900 Endoderm Anatomy 0.000 claims 1
- 210000000277 Pancreatic Ducts Anatomy 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 210000000496 Pancreas Anatomy 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
Abstract
การประดิษฐ์นี้จัดเสนอวิธีการที่จะส่งเสริมให้สเต็มเซลล์ซึ่งมีคุณสมบัติเป็นพลูริโพเทนต์ เกิดการเปลี่ยนแปลงไปสู่เซลล์ที่ผลิตอินซูลิน โดยเฉพาะอย่างยิ่ง การประดิษฐ์นี้จัดเสนอวิธีการที่จะ เพิ่มการแสดงออกของ NGN3 และ NKX6.1 ในกลุ่มประชากรของเซลล์ที่มีการแสดงออกของ ตัวบ่งชี้(marker)ซึ่งเป็นลักษณะเฉพาะของเซลล์ที่สืบเชื้อสายมาจากต่อมไร้ท่อของตับอ่อน This invention offers a method to promote the proliferation of stem cells that qualify as pluripotent. This changes to insulin-producing cells. Especially This invention provides a method to Increase the expression of NGN3 and NKX6.1 in the cell population with the expression of An indicator (marker), which is a characteristic of cells that descend from the pancreas endocrine glands.
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH133352A TH133352A (en) | 2014-05-06 |
| TH133352B true TH133352B (en) | 2014-05-06 |
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