TH136566B - The synthesis process of Muthyanant Benzosazinone to be used as a precursor to Deferrazirox synthesis - Google Patents

The synthesis process of Muthyanant Benzosazinone to be used as a precursor to Deferrazirox synthesis

Info

Publication number
TH136566B
TH136566B TH1301001120A TH1301001120A TH136566B TH 136566 B TH136566 B TH 136566B TH 1301001120 A TH1301001120 A TH 1301001120A TH 1301001120 A TH1301001120 A TH 1301001120A TH 136566 B TH136566 B TH 136566B
Authority
TH
Thailand
Prior art keywords
synthesis
muthyanant
deferrazirox
benzosazinone
precursor
Prior art date
Application number
TH1301001120A
Other languages
Thai (th)
Other versions
TH136566A (en
Inventor
นางสาวภาวิณี พงษ์วัน นางสาวอรศิริ ศรีคุณ นายสุวัชชัย จรัสโสภณ
Original Assignee
องค์การเภสัชกรรม
Filing date
Publication date
Application filed by องค์การเภสัชกรรม filed Critical องค์การเภสัชกรรม
Publication of TH136566A publication Critical patent/TH136566A/en
Publication of TH136566B publication Critical patent/TH136566B/en

Links

Abstract

การประดิษฐ์นี้ได้เปิดเผยการสังเคราะห์ 2-(2-ไฮดรอกซีฟีนิล)เบนซ(อี)(1,3)ออกซาซิน-4- โอน(2(2-hydroxypheny1)benz[e][1,3]oxaxin-4-one)จากกรดซลิไซลิก ซาลิไซลาไมด์ โดยใช้ ไซยานูบริคลอไรด์ โดยใช้ปฏิกิริยากลั่นกลับในโทลูอีน การประดิษฐ์นี้ได้ลดอุณหภูมิการทำปฏิกิริยา ลงทำให้สภาวะทำปฏิกิริยาไม่รุนเเรง เเละได้ผลิตภัณฑ์ที่มีความบริสุทธิ์สูง This invention revealed a synthesis 2- (2-hydroxyphenyl) benz (e) (1,3) oxacin-4-transfer (2 (2-hydroxypheny1) benz [e] [1,3] oxaxin-4- one) from salicylic acid salicylamide using cyanubrychloride. By using a reverse distillation reaction in toluene This invention reduced the reaction temperature. Down, causing the reaction condition to be mild And get products with high purity

Claims (1)

1.กรรมวิธีการสัวเคราะห์ 2-(2-ไฮดรอกซีฟีนิล)เบนซ(อี)(1,3)ออกซาซิน-4-โอน(2(2- hydroxypheny1)benz[e][1,3]oxaxin-4-one)ที่ประกอยด้วยการนำกรดซลิไซลิก ซาลิไซลาไมด์ เเละ ไซยานูบริคลอไรด์ มาทำปฏิกิริยากลั่นกลับ ในโทลูอีน1. The survey method 2- (2-hydroxyphenyl) benz (e) (1,3) oxacin-4-transfer (2 (2- hydroxypheny1) benz [e] [1,3] oxaxin-4- one) applied by the introduction of salicylic acid salicylamide and cyanubryloride To react distillate into toluene
TH1301001120A 2013-03-06 The synthesis process of Muthyanant Benzosazinone to be used as a precursor to Deferrazirox synthesis TH136566B (en)

Publications (2)

Publication Number Publication Date
TH136566A TH136566A (en) 2014-09-19
TH136566B true TH136566B (en) 2014-09-19

Family

ID=

Similar Documents

Publication Publication Date Title
CY1125155T1 (en) CRYSTAL FORMS OF PROLYL HYDROSYLASE INHIBITOR
BR112014018756A8 (en) PROCESS FOR PREPARING N-(4-CYCLO-HEXYL-3-TRIFLUOROMETHYL-BENZYLOXY)-ACETIMIDIC ACID ETHYL ESTER
IN2015DN01163A (en)
MX2016007297A (en) Process for purifying 2,5-dichlorophenol.
MY164527A (en) Process for production of acrylic acid or its derivatives
BR112015029175A2 (en) process for preparing levulinic acid
BR112016008895A8 (en) methods for the formation of homoalicylic compounds by the reaction of cyclopropyl vinyl precursors with bronsted acid, and for the formation of ambrox
IN2014DN08777A (en)
WO2016190501A8 (en) Compound for organic optoelectronic device, composition for organic optoelectronic device, and organic optoelectronic device and display device comprising same
WO2015104721A3 (en) An improved process for the preparation of tranexamic acid
WO2014141092A3 (en) Improved process for the preparation of tenofovir
EA028190B9 (en) Nitrogen monoxide as cis/trans isomerization catalyst for unsaturated compounds
FR2985998B1 (en) PROCESS FOR THE PRODUCTION OF 2-OCTYL ACRYLATE BY TRANSESTERIFICATION
TH136566B (en) The synthesis process of Muthyanant Benzosazinone to be used as a precursor to Deferrazirox synthesis
TR201902673T4 (en) Processes for the preparation of compounds useful in the synthesis of medetomidine, such as 3-arylbutanes.
WO2015134599A3 (en) Platinum(iv) compounds and methods of making and using same
WO2014173917A8 (en) Synthesis of bace inhibitors
BR112014018492A8 (en) IMPROVED PROCESS FOR THE PRODUCTION OF 1,1-DISUBSTITUTED ETHYLENE
BR112014023999B8 (en) process of preparing spirocyclic phenylacetylaminoacid esters with cis-alkoxy substitution and spirocyclic 1h-pyrrolidine-2,4-dione derivatives with cis-alkoxy substitution
LT2012082A (en) Novel photochromic compounds, process for preparing therof and intermediates thereof
MY180075A (en) Catalyst and process
BRPI0907283A8 (en) METHOD TO STABILIZE LIQUID NITRO COMPOUNDS AGAINST DISCOLORATION
TH136566A (en) Benzosazinone synthesis process for use as a precursor to the synthesis of deferazirox.
IN2014DN09170A (en)
IN2015DN03111A (en)