IN2015DN01163A - - Google Patents

Info

Publication number
IN2015DN01163A
IN2015DN01163A IN1163DEN2015A IN2015DN01163A IN 2015DN01163 A IN2015DN01163 A IN 2015DN01163A IN 1163DEN2015 A IN1163DEN2015 A IN 1163DEN2015A IN 2015DN01163 A IN2015DN01163 A IN 2015DN01163A
Authority
IN
India
Prior art keywords
syndrome
mediated
disorder
transportation
disease
Prior art date
Application number
Inventor
Jan Jiricek
Ravinder Reddy Kondreddi
Paul William Smith
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IN2015DN01163A publication Critical patent/IN2015DN01163A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A compound of Formula (I) is provided that has been shown to be useful for treating a disease, disorder or syndrome that is mediated by the transportation of essential molecules in the mmpL3 pathway: (I) wherein R1, R2, R3, R4, R5 and R6 are as defined herein.
IN1163DEN2015 2012-09-07 2015-02-12 IN2015DN01163A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261698033P 2012-09-07 2012-09-07
PCT/IB2013/058318 WO2014037900A1 (en) 2012-09-07 2013-09-05 Indole carboxamide derivatives and uses thereof

Publications (1)

Publication Number Publication Date
IN2015DN01163A true IN2015DN01163A (en) 2015-06-26

Family

ID=49585451

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1163DEN2015 IN2015DN01163A (en) 2012-09-07 2015-02-12

Country Status (11)

Country Link
US (3) US9447039B2 (en)
EP (1) EP2892880B1 (en)
JP (1) JP6223452B2 (en)
KR (1) KR20150048759A (en)
CN (1) CN104603106B (en)
BR (1) BR112015004666B1 (en)
CA (1) CA2881351A1 (en)
EA (1) EA028093B1 (en)
ES (1) ES2660210T3 (en)
IN (1) IN2015DN01163A (en)
WO (1) WO2014037900A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CR20160514A (en) * 2014-04-04 2017-07-26 Iomet Pharma Ltd INDOL DERIVATIVES FOR USE IN MEDICINE
WO2015164482A1 (en) * 2014-04-22 2015-10-29 The Johns Hopkins University Inhibitors of drug-resistant mycobacterium tuberculosis
SG11201703188QA (en) * 2014-10-24 2017-05-30 Bristol Myers Squibb Co Indole carboxamides compounds useful as kinase inhibitors
CN107298650B (en) * 2016-04-15 2022-11-15 浙江中科创越药业有限公司 Heterocyclic carboxylic acid amide ligands and their use in copper catalyzed aryl halide coupling reactions
CN106085868B (en) * 2016-06-15 2019-07-12 中国医学科学院医药生物技术研究所 One plant of Aspergillus and its application
US10383848B2 (en) * 2016-08-04 2019-08-20 Creighton University Indole-based therapeutics
US10858319B2 (en) 2016-10-03 2020-12-08 Iomet Pharma Ltd. Indole derivatives for use in medicine
WO2018165612A1 (en) 2017-03-10 2018-09-13 Rutgers, The State University Of New Jersey Bacterial efflux pump inhibitors
WO2018165614A1 (en) 2017-03-10 2018-09-13 Rutgers, The State University Of New Jersey Bacterial efflux pump inhibitors
CN110770224B (en) 2017-03-10 2022-11-18 罗格斯新泽西州立大学 Indole derivatives as efflux pump inhibitors
WO2018218192A1 (en) 2017-05-26 2018-11-29 Rutgers, The State University Of New Jersey Bacterial efflux pump inhibitors
WO2019005841A1 (en) * 2017-06-26 2019-01-03 Rutgers, The State University Of New Jersey Therapeutic compounds and methods to treat infection
WO2019220461A1 (en) * 2018-05-17 2019-11-21 Council Of Scientific And Industrial Research Indole compounds, process for the preparation and use thereof
KR102219563B1 (en) * 2019-02-15 2021-02-24 에스티팜 주식회사 Intermediates for the production of phenazine derivative and methods for their preparation
CN114746089A (en) * 2019-09-26 2022-07-12 结核病药物开发全球联盟公司 Thiazolecarboxamide compounds and their use for the treatment of mycobacterial infections
CN110577483B (en) * 2019-09-26 2020-05-12 海南医学院 Green synthesis method of 3, 3-disubstituted-2-indolone
US20230040909A1 (en) * 2019-09-26 2023-02-09 The Global Alliance For Tb Drug Development, Inc. Indole carboxamide compounds and use thereof for the treatment of mycobacterial infections
BR112022005736A2 (en) * 2019-09-26 2022-08-23 The Global Alliance For Tb Drug Dev Inc AZAINDOL CARBOXAMIDE COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS
RU2767542C1 (en) * 2021-05-24 2022-03-17 Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (ПГНИУ) Anti-tuberculosis agent based on 4-((het)aroyl)-3-hydroxy-1-(2-hydroxyphenyl)-5-(phenylthio)-1,5-dihydro-2h-pyrrol-2-ones
CN115583908B (en) * 2021-07-05 2024-08-06 西北农林科技大学 Indolecarboxamide compound and preparation method and use thereof
US12012398B2 (en) * 2021-07-12 2024-06-18 Nido Biosciences, Inc. Bicyclic compounds as androgen receptor modulators
WO2024118858A1 (en) * 2022-12-02 2024-06-06 Merck Sharp & Dohme Llc Preparation of fused azole derivatives as novel diacylglyceride o-acyltransferase 2 inhibitors
CN118724763B (en) * 2024-09-02 2024-12-06 辽宁龙田化工科技有限公司 Synthesis method of 4-methylbenzenesulfonyl chloride

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US883049A (en) * 1907-09-12 1908-03-24 John W Piver Tongue-and-groove joint for flooring.
FR2705095B1 (en) * 1993-05-12 1995-06-23 Adir New substituted indoles, process for their preparation and pharmaceutical compositions containing them.
HU227197B1 (en) * 2000-10-24 2010-10-28 Richter Gedeon Nyrt Nmda receptor antagonist carboxylic acid amide derivatives and pharmaceutical compositions containing them
WO2003000657A1 (en) 2001-06-20 2003-01-03 Daiichi Pharmaceutical Co., Ltd. Diamine derivatives
JP4623962B2 (en) 2001-10-22 2011-02-02 ザ・リサーチ・ファウンデーション・オブ・ステイト・ユニバーシティ・オブ・ニューヨーク Protein kinases and phosphatase inhibitors, methods of designing them, and methods of using them
US6759428B2 (en) 2001-12-04 2004-07-06 Roche Palo Alto Llc Indole nitriles
DE60219068T2 (en) 2001-12-04 2007-12-13 F. Hoffmann-La Roche Ag SUBSTITUTED 2-AMINO CYKLOAL KANKARBOXAMIDES AND THEIR USE AS CYSTEIN PROTEASE INHIBITORS
WO2004078163A2 (en) 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
WO2003091213A1 (en) * 2002-04-25 2003-11-06 Yamanouchi Pharmaceutical Co., Ltd. Novel amide derivatives or salts thereof
GB0428173D0 (en) * 2004-12-23 2005-01-26 Astrazeneca Ab Compounds
US8691859B2 (en) * 2005-08-12 2014-04-08 The United States Of America As Represented By The Secretary Of The Army Broad spectrum antibacterial compounds
MX2008012734A (en) 2006-04-04 2009-01-29 Fibrogen Inc Pyrrolo- and thiazolo-pyridine compounds as hif modulators.
WO2009063495A2 (en) 2007-09-20 2009-05-22 Cadila Healthcare Limited Substituted indole and its derivatives as cannabinoid modulators
ES2443948T3 (en) 2008-12-19 2014-02-21 Bristol-Myers Squibb Company Carbazole carboxamide compounds useful as kinase inhibitors
CN102395273B (en) 2009-02-27 2015-05-20 西佳技术公司 Thienopyridine derivatives for the treatment and prevention of dengue virus infections
AR077346A1 (en) 2009-07-31 2011-08-17 Biocryst Pharm Inc HETEROCICLICAL COMPOUNDS AS INHIBITORS OF JANUS QUINASA
EP2521724B1 (en) 2009-12-11 2016-11-23 Nono Inc. Agents and methods for treating ischemic and other diseases
JP2012107001A (en) 2010-10-22 2012-06-07 Shionogi & Co Ltd Drug containing indole amide compound
US9200046B2 (en) * 2011-06-29 2015-12-01 Cornell University Reporter system for high throughput screening of compounds and uses thereof

Also Published As

Publication number Publication date
US20150175539A1 (en) 2015-06-25
CA2881351A1 (en) 2014-03-13
BR112015004666A2 (en) 2017-07-04
AU2013311235A1 (en) 2015-02-26
BR112015004666B1 (en) 2022-04-26
AU2013311235B2 (en) 2016-03-24
WO2014037900A1 (en) 2014-03-13
US9447039B2 (en) 2016-09-20
KR20150048759A (en) 2015-05-07
JP6223452B2 (en) 2017-11-01
EA028093B1 (en) 2017-10-31
EP2892880B1 (en) 2017-11-22
JP2015527388A (en) 2015-09-17
CN104603106A (en) 2015-05-06
US20160355477A1 (en) 2016-12-08
ES2660210T3 (en) 2018-03-21
CN104603106B (en) 2017-05-10
EA201590504A1 (en) 2015-07-30
EP2892880A1 (en) 2015-07-15
US20210032202A1 (en) 2021-02-04

Similar Documents

Publication Publication Date Title
IN2015DN01163A (en)
EA201591527A1 (en) NEW PYRIDINE DERIVATIVES
PH12015501083B1 (en) Novel pyridine derivatives
MX2015015412A (en) Novel compounds and pharmaceutical compositions thereof for the treatment of cystic fibrosis.
MX350539B (en) Enediyne compounds, conjugates thereof, and uses and methods therefor.
MY176814A (en) Compounds and pharmaceutical compositions thereof for the treatment of cystic fibrosis
MY182328A (en) Pyridine-2-amides useful as cb2 agonists
EA201291317A1 (en) TETRAGIDROPYRIDOPYRIMIDINE DERIVATIVES
PH12015501933A1 (en) Novel pyridine derivatives
MY176797A (en) Novel pyrazol derivatives
MX2014004920A (en) Novel pyrazine derivatives.
PH12015501038A1 (en) Inhibitors of iap
MX2014008918A (en) Novel pyrrolidine derivatives.
MX363458B (en) Novel tetrazolone derivatives.
PH12015500262A1 (en) Novel pyridine derivatives
MX351093B (en) Novel azetidine derivatives.
IN2015DN02513A (en)
PH12016500541A1 (en) Use of odiparcil in the treatment of a mucopolysaccharidosis
MX2014010481A (en) New compositions for treating amyotrophic lateral sclerosis.