TH133923B - 1,3 oxazine as an inhibitor of BACE1 and / or BACE2 - Google Patents
1,3 oxazine as an inhibitor of BACE1 and / or BACE2Info
- Publication number
- TH133923B TH133923B TH1301005839A TH1301005839A TH133923B TH 133923 B TH133923 B TH 133923B TH 1301005839 A TH1301005839 A TH 1301005839A TH 1301005839 A TH1301005839 A TH 1301005839A TH 133923 B TH133923 B TH 133923B
- Authority
- TH
- Thailand
- Prior art keywords
- bace2
- bace1
- oxazine
- inhibitor
- substances
- Prior art date
Links
- 102100015650 BACE1 Human genes 0.000 title abstract 2
- 101700051112 BACE1 Proteins 0.000 title abstract 2
- 102100015648 BACE2 Human genes 0.000 title abstract 2
- 101700051947 BACE2 Proteins 0.000 title abstract 2
- KGWNRZLPXLBMPS-UHFFFAOYSA-N 2H-1,3-oxazine Chemical compound C1OC=CC=N1 KGWNRZLPXLBMPS-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 239000000126 substance Substances 0.000 claims abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 abstract 2
- 230000001225 therapeutic Effects 0.000 abstract 2
- -1 3- amino-phenyl Chemical group 0.000 abstract 1
- 206010001897 Alzheimer's disease Diseases 0.000 abstract 1
- 208000001072 Type 2 Diabetes Mellitus Diseases 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 230000003449 preventive Effects 0.000 abstract 1
Abstract
การประดิษฐ์นี้เสนอ 4-(3-อะมิโน-เฟนิล)-5,6-ไดไฮโดร-4H-[1,3]ออกซาซิน-2-อิลเอมีน ตามสูตร I (สูตรเคมี) I ซึ่งมีฤทธิ์ยับยั้ง BACE1 และ/หรือ BACE2, การผลิตสารดังกล่าว,องค์ประกอบทางเภสัชกรรมที่มี สารดังกล่าว และการใช้สารดังกล่าวในฐานะสารออกฤทธิ์ทางการบำบัด สารออกฤทธิ์ตามการ ประดิษฐ์นี้มีประโยชน์ในการรักษาเชิงบำบัดและ/หรือเชิงป้องกันสำหรับอาทิเช่นโรคอัลไซเมอร์ และเบาหวานประเภท 2 This invention offers 4- (3- amino-phenyl) -5,6-dihydro-4H- [1,3] oxacin-2-ilamine according to formula I (chemical formula) I, which has the Inhibits BACE1 and / or BACE2, production of such substances, pharmaceutical constituents containing such substances and their use as therapeutic active ingredients. Active ingredient according to This invention is useful as a therapeutic and / or preventive treatment for such as Alzheimer's disease. And type 2 diabetes
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH133923A TH133923A (en) | 2014-05-26 |
| TH133923B true TH133923B (en) | 2014-05-26 |
Family
ID=
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