TH147171A - Halogen-alkyl-1,3 Oxacine as a BACE1 and / or BACE2 inhibitor - Google Patents
Halogen-alkyl-1,3 Oxacine as a BACE1 and / or BACE2 inhibitorInfo
- Publication number
- TH147171A TH147171A TH1301006943A TH1301006943A TH147171A TH 147171 A TH147171 A TH 147171A TH 1301006943 A TH1301006943 A TH 1301006943A TH 1301006943 A TH1301006943 A TH 1301006943A TH 147171 A TH147171 A TH 147171A
- Authority
- TH
- Thailand
- Prior art keywords
- substances
- therapeutic
- formula
- bace1
- bace2
- Prior art date
Links
- 102100015650 BACE1 Human genes 0.000 title claims abstract 5
- 101700051112 BACE1 Proteins 0.000 title claims abstract 5
- 102100015648 BACE2 Human genes 0.000 title claims abstract 5
- 101700051947 BACE2 Proteins 0.000 title claims abstract 5
- 230000002401 inhibitory effect Effects 0.000 title claims abstract 3
- 239000003112 inhibitor Substances 0.000 title 1
- 239000000126 substance Substances 0.000 claims abstract 10
- 239000004480 active ingredient Substances 0.000 claims abstract 7
- 230000001225 therapeutic Effects 0.000 claims abstract 7
- 150000001875 compounds Chemical class 0.000 claims abstract 5
- 206010001897 Alzheimer's disease Diseases 0.000 claims abstract 4
- 208000001072 Type 2 Diabetes Mellitus Diseases 0.000 claims abstract 4
- 239000005426 pharmaceutical component Substances 0.000 claims abstract 4
- 230000003449 preventive Effects 0.000 claims abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Abstract
DC60 (06/12/56) การประดิษฐ์นี้เสนอสารประกอบตามสูตร I (สูตรเคมี) I ซึ่งมีฤทธิ์ยับยั้ง BACE1 เเละ/หรือ BACE2, การผลิตสารดังกล่าว, องค์ประกอบทางเภสัชกรรมที่มีสาร ดังกล่าว เเละการใช้สารดังกล่าวในฐานะสารออกฤทธิ์ทางการบำบัด สารออกฤทธิ์ตามการประดิษฐ์นี้ มีประโยชน์ในการรักษาเชิงบำบัดเเละ/หรือเชิงป้องกันสำหรับอาทิเช่นโรคอัลไซเมอร์เเละเบาหวาน ประเภท 2 การประดิษฐ์นี้เสนอสารประกอบตามสูตร I ซึ่งมีฤทธิ์ยับยั้ง BACE1 เเละ/หรือ BACE2 การผลิตสารดังกล่าว องค์ประกอบทางเภสัชกรรมที่มีสาร ดังกล่าว เเละการใช้สารดังกล่าวในฐานะสารออกฤทธิ์ทางการบำบัด สารออกฤทธิ์ตามการประดิษฐ์นี้ มีประโยชน์ในการรักษาเชิงบำบัดเเละ/หรือเชิงป้องกันสำหรับอาทิเช่นโรคอัลไซเมอร์เเละเบาหวาน ประเภท 2 สิทธิบัตรยา DC60 (06/12/56) This invention proposes a compound based on formula I (chemical formula) I, which has inhibitory effects of BACE1 and / or BACE2, the production of such substances, pharmaceutical components containing such substances and their use. Mentioned as an active ingredient in therapy Active ingredient according to this invention It is useful as a therapeutic and / or preventive treatment for such as Alzheimer's disease and type 2 diabetes. The invention proposes a compound based on formula I which inhibits BACE1 and / or BACE2. say Pharmaceutical components containing such substances and their use as therapeutic active ingredients. Active ingredient according to this invention It is useful as a therapeutic and / or preventive treatment for such as Alzheimer's disease and type 2 diabetes.
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TH147171A true TH147171A (en) | 2016-03-04 |
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