TH131395B - Bisocyclic thiazole is an allosteric modulator of MGLUR5 receptors (BICYCLIC THIAZOLES AS ALLOSTERIC MODULATERS OF MGLUR5 RECEPTORS). - Google Patents
Bisocyclic thiazole is an allosteric modulator of MGLUR5 receptors (BICYCLIC THIAZOLES AS ALLOSTERIC MODULATERS OF MGLUR5 RECEPTORS).Info
- Publication number
- TH131395B TH131395B TH1201002768A TH1201002768A TH131395B TH 131395 B TH131395 B TH 131395B TH 1201002768 A TH1201002768 A TH 1201002768A TH 1201002768 A TH1201002768 A TH 1201002768A TH 131395 B TH131395 B TH 131395B
- Authority
- TH
- Thailand
- Prior art keywords
- allosteric
- mglur5
- mglur5 receptors
- bisocyclic
- modulaters
- Prior art date
Links
- 230000003281 allosteric Effects 0.000 title abstract 3
- 230000000051 modifying Effects 0.000 title abstract 2
- 102100006612 GRM5 Human genes 0.000 title 2
- 101700027086 GRM5 Proteins 0.000 title 2
- FZWLAAWBMGSTSO-UHFFFAOYSA-N thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 title 2
- 150000001875 compounds Chemical class 0.000 claims abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 102000012777 Metabotropic Glutamate 5 Receptor Human genes 0.000 abstract 4
- 108010065028 Metabotropic Glutamate 5 Receptor Proteins 0.000 abstract 4
- 201000010099 disease Diseases 0.000 abstract 4
- 230000002265 prevention Effects 0.000 abstract 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- 102000016193 Metabotropic Glutamate Receptors Human genes 0.000 abstract 1
- 108010010914 Metabotropic Glutamate Receptors Proteins 0.000 abstract 1
- -1 bicyclic thiazoles Chemical class 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 239000005426 pharmaceutical component Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Abstract
การประดิษฐ์นี้เกี่ยวข้องกับไพไซคลิกไธอะโซล (Bicyclic thiazoles ) ชนิดใหม่ซึ่งเป็นโพสิทีพ อัลโลสเตอริกโมดูเลเตอร์ (Positive allosteric modulators) ของเมตาโบโทรปิคกลูตาเมตรีเซพเตอร์สับไทป์ 5 (mGluR5) (Metabotropic glutamate receptor subtype 5) และซึ่งใช้ประโยชน์สำหรับการบำบัดหรือการ ป้องกันความผิดปกติของโรคที่เกี่ยวกับการทำงานไม่เป็นปกติและโรคของกลูตาเมตในที่ซึ่ง mGluR5 สับ ไทป์ของรีเซพเตอร์มีความเกี่ยวข้อง การประดิษฐ์ยังมุ่งถึงองค์ประกอบทางเภสัชกรรมที่ประกอบด้วย สารประกอบดังกล่าวนี้, มุ่งถึงกระบวนการสำหรับการเตรียมสารประกอบและองค์ประกอบดังกล่าวนี้ และมุ่งถึงการใช้สารประกอบและองค์ประกอบดังกล่าวนี้สำหรับการป้องกันและการบำบัดความผิดปกติ ของโรคในที่ซึ่ง mGluR5 มีความเกี่ยวข้อง The invention involved a new type of bicyclic thiazoles, which are positides. Positive allosteric modulators of the metabotropic glutamate receptor 5 (mGluR5) (Metabotropic glutamate receptor subtype 5) and which are utilized for Therapy or Prevention of functional disorders and glutamate diseases in which the receptor mGluR5 shunt is involved. The invention also focuses on the pharmaceutical components that include This compound, geared towards the preparation of these compounds and elements. And the use of these compounds and constituents for the prevention and treatment of disorders Of disease where mGluR5 is relevant
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH131395B true TH131395B (en) | 2014-02-27 |
| TH131395A TH131395A (en) | 2014-02-27 |
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