TH113762B - Process for the production of 5- (2 - ((6- (2,2-difluoro-2-phenylethoxy) hexyl] amino) -1-hydroxyethyl) -8-hydroxyquinolin-2 (1H) -Transfer - Google Patents
Process for the production of 5- (2 - ((6- (2,2-difluoro-2-phenylethoxy) hexyl] amino) -1-hydroxyethyl) -8-hydroxyquinolin-2 (1H) -TransferInfo
- Publication number
- TH113762B TH113762B TH1101001957A TH1101001957A TH113762B TH 113762 B TH113762 B TH 113762B TH 1101001957 A TH1101001957 A TH 1101001957A TH 1101001957 A TH1101001957 A TH 1101001957A TH 113762 B TH113762 B TH 113762B
- Authority
- TH
- Thailand
- Prior art keywords
- formula
- chemical formula
- difluoro
- compound
- hydroxyquinolin
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 5
- -1 2,2-difluoro-2-phenylethoxy Chemical group 0.000 title claims abstract 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title claims abstract 3
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 9
- 239000000126 substance Substances 0.000 claims abstract 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 239000011780 sodium chloride Substances 0.000 claims abstract 2
- 239000002904 solvent Substances 0.000 claims abstract 2
- 230000036469 Elimination phase Effects 0.000 abstract 2
Abstract
กระบวนการสำหรับการเตรียมสารประกอบ5-(2-{[6-(2,2-ไดฟลูออโร-2-ฟีนิลเอทธอกซี)-เฮกซิล]อะมิโน}-1-ไฮดรอกซีเอทธิล)-8-ไฮดรอกซีควิโนลิน-2(1H)-โอนที่มีสูตร(I),หรือเกลือที่ยอมรับได้ทางเภสัชกรรมของสารประกอบนี้,(สูตรเคมี)ซึ่งกระบวนการประกอบด้วย a)การเกิดปฏิกิริยา,ในตัวทำละลายชนิดไซลีน,ของสารประกอบที่มีสูตร(V)(สูตรเคมี)ซึ่งP1และP2แสดงถึงหมู่ปกป้องไฮดรอกซีและLคือหมู่ที่หลุดออก,กับ6-(2,2-ไดฟลูออโร-2-ฟีนิลเอทธอกซี)เฮกซาน-1-เอมีนที่มีสูตร(IV),(สูตรเคมี)เพื่อให้สารประกอบที่มีสูตร(III)(สูตรเคมี) b)การทำให้เกิดขึ้นของขั้นตอนของการขจัดการปกป้องP1และขั้นตอนของการขจัดการป้องกันP2,เพื่อที่จะกำจัดหมู่ปกป้องP1และP2และให้สารประกอบที่มีสูตร(I): The process for the preparation of compounds 5- (2 - {[6- (2,2-difluoro-2-phenylethoxy) -hexyl] amino} -1-hydroxyl. Oxyethyl) -8-hydroxyquinolin-2 (1H) - transferred with the formula (I), or the pharmacologically acceptable salt of this compound, (chemical formula) in which the process consists of a) Reactivity, in xylene-type solvent, of compounds with formula (V) (chemical formula) where P1 and P2 represent hydroxy protection groups and L are loosened groups, with 6- ( 2,2-difluoro-2-phenylethylethoxy) hexan-1-amine with formula (IV), (chemical formula) to give compound with formula (III) (chemical formula ) b) the establishment of the P1 elimination phase and the P2 protection elimination phase, in order to eliminate the P1 and P2 protection groups and provide a compound with formula (I):
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH113762B true TH113762B (en) | 2012-05-15 |
| TH113762A TH113762A (en) | 2012-05-15 |
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