PL396539A1 - Method for preparing new derivatives of 1-[(2-alkyl-2H-1 ,2,3-triazol-4-yl)methyl]pyrimidine-2,4(1H, 3H)-dione - Google Patents

Method for preparing new derivatives of 1-[(2-alkyl-2H-1 ,2,3-triazol-4-yl)methyl]pyrimidine-2,4(1H, 3H)-dione

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Publication number
PL396539A1
PL396539A1 PL396539A PL39653911A PL396539A1 PL 396539 A1 PL396539 A1 PL 396539A1 PL 396539 A PL396539 A PL 396539A PL 39653911 A PL39653911 A PL 39653911A PL 396539 A1 PL396539 A1 PL 396539A1
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PL
Poland
Prior art keywords
triazol
pyrimidine
methyl
dione
general formula
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PL396539A
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Polish (pl)
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PL216586B1 (en
Inventor
Mariola Koszytkowska-Stawinska
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Politechnika Warszawska
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Application filed by Politechnika Warszawska filed Critical Politechnika Warszawska
Priority to PL396539A priority Critical patent/PL216586B1/en
Publication of PL396539A1 publication Critical patent/PL396539A1/en
Publication of PL216586B1 publication Critical patent/PL216586B1/en

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Abstract

Przedmiotem wynalazku jest sposób otrzymywania nowych pochodnych 1-[(2-alkilo-2H-1,2,3-triazol-4-ylo)metylo]pirymidyno- 2,4(1H,3H)-dionu o wzorze ogólnym 1, mogacych znalezc zastosowanie w produkcji srodków farmaceutycznych. W pierwszym etapie 3-(piwaloiloksymetylo)-1-[(NH-1,2,3-triazol-4-ylo)metylo] pirymidyno-2,4(1H,3H)-dion o wzorze ogólnym 3 poddaje sie reakcji ze zwiazkiem o wzorze ogólnym 2 prowadzonej w rozpuszczalniku organicznym. W drugim etapie, wyodrebnione produkty posrednie o wzorze ogólnym 4 poddaje sie kolejno dzialaniu amoniaku w roztworze wodno-alkoholowym lub dzialaniu amoniaku w roztworze alkoholowym, a nastepnie bromku trimetylosylilu w roztworze acetonitrylu w temperaturze pokojowej.The present invention relates to a process for the preparation of new 1 - [(2-alkyl-2H-1,2,3-triazol-4-yl) methyl] pyrimidine-2,4 (1H, 3H) -dione derivatives of general formula 1 which can be found use in the production of pharmaceuticals. In the first step, 3- (pivaloyloxymethyl) -1 - [(NH-1,2,3-triazol-4-yl) methyl] pyrimidine-2,4 (1H, 3H) -dione of general formula 3 is reacted with a compound of general formula 2 carried out in an organic solvent. In the second stage, the separated intermediate products of general formula 4 are treated successively with ammonia in an aqueous-alcoholic solution or with ammonia in an alcoholic solution, followed by trimethylsilyl bromide in acetonitrile solution at room temperature.

PL396539A 2011-10-04 2011-10-04 Method for preparing new derivatives of 1-[(2-alkyl-2H-1 ,2,3-triazol-4-yl)methyl]pyrimidine-2,4(1H, 3H)-dione PL216586B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL396539A PL216586B1 (en) 2011-10-04 2011-10-04 Method for preparing new derivatives of 1-[(2-alkyl-2H-1 ,2,3-triazol-4-yl)methyl]pyrimidine-2,4(1H, 3H)-dione

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL396539A PL216586B1 (en) 2011-10-04 2011-10-04 Method for preparing new derivatives of 1-[(2-alkyl-2H-1 ,2,3-triazol-4-yl)methyl]pyrimidine-2,4(1H, 3H)-dione

Publications (2)

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PL396539A1 true PL396539A1 (en) 2013-04-15
PL216586B1 PL216586B1 (en) 2014-04-30

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PL396539A PL216586B1 (en) 2011-10-04 2011-10-04 Method for preparing new derivatives of 1-[(2-alkyl-2H-1 ,2,3-triazol-4-yl)methyl]pyrimidine-2,4(1H, 3H)-dione

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PL216586B1 (en) 2014-04-30

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