PL396539A1 - Method for preparing new derivatives of 1-[(2-alkyl-2H-1 ,2,3-triazol-4-yl)methyl]pyrimidine-2,4(1H, 3H)-dione - Google Patents
Method for preparing new derivatives of 1-[(2-alkyl-2H-1 ,2,3-triazol-4-yl)methyl]pyrimidine-2,4(1H, 3H)-dioneInfo
- Publication number
- PL396539A1 PL396539A1 PL396539A PL39653911A PL396539A1 PL 396539 A1 PL396539 A1 PL 396539A1 PL 396539 A PL396539 A PL 396539A PL 39653911 A PL39653911 A PL 39653911A PL 396539 A1 PL396539 A1 PL 396539A1
- Authority
- PL
- Poland
- Prior art keywords
- triazol
- pyrimidine
- methyl
- dione
- general formula
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Przedmiotem wynalazku jest sposób otrzymywania nowych pochodnych 1-[(2-alkilo-2H-1,2,3-triazol-4-ylo)metylo]pirymidyno- 2,4(1H,3H)-dionu o wzorze ogólnym 1, mogacych znalezc zastosowanie w produkcji srodków farmaceutycznych. W pierwszym etapie 3-(piwaloiloksymetylo)-1-[(NH-1,2,3-triazol-4-ylo)metylo] pirymidyno-2,4(1H,3H)-dion o wzorze ogólnym 3 poddaje sie reakcji ze zwiazkiem o wzorze ogólnym 2 prowadzonej w rozpuszczalniku organicznym. W drugim etapie, wyodrebnione produkty posrednie o wzorze ogólnym 4 poddaje sie kolejno dzialaniu amoniaku w roztworze wodno-alkoholowym lub dzialaniu amoniaku w roztworze alkoholowym, a nastepnie bromku trimetylosylilu w roztworze acetonitrylu w temperaturze pokojowej.The present invention relates to a process for the preparation of new 1 - [(2-alkyl-2H-1,2,3-triazol-4-yl) methyl] pyrimidine-2,4 (1H, 3H) -dione derivatives of general formula 1 which can be found use in the production of pharmaceuticals. In the first step, 3- (pivaloyloxymethyl) -1 - [(NH-1,2,3-triazol-4-yl) methyl] pyrimidine-2,4 (1H, 3H) -dione of general formula 3 is reacted with a compound of general formula 2 carried out in an organic solvent. In the second stage, the separated intermediate products of general formula 4 are treated successively with ammonia in an aqueous-alcoholic solution or with ammonia in an alcoholic solution, followed by trimethylsilyl bromide in acetonitrile solution at room temperature.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL396539A PL216586B1 (en) | 2011-10-04 | 2011-10-04 | Method for preparing new derivatives of 1-[(2-alkyl-2H-1 ,2,3-triazol-4-yl)methyl]pyrimidine-2,4(1H, 3H)-dione |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL396539A PL216586B1 (en) | 2011-10-04 | 2011-10-04 | Method for preparing new derivatives of 1-[(2-alkyl-2H-1 ,2,3-triazol-4-yl)methyl]pyrimidine-2,4(1H, 3H)-dione |
Publications (2)
Publication Number | Publication Date |
---|---|
PL396539A1 true PL396539A1 (en) | 2013-04-15 |
PL216586B1 PL216586B1 (en) | 2014-04-30 |
Family
ID=48536283
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL396539A PL216586B1 (en) | 2011-10-04 | 2011-10-04 | Method for preparing new derivatives of 1-[(2-alkyl-2H-1 ,2,3-triazol-4-yl)methyl]pyrimidine-2,4(1H, 3H)-dione |
Country Status (1)
Country | Link |
---|---|
PL (1) | PL216586B1 (en) |
-
2011
- 2011-10-04 PL PL396539A patent/PL216586B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
PL216586B1 (en) | 2014-04-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX361759B (en) | Dihydropyridone p1 as factor xia inhibitors. | |
TW201613923A (en) | Pyrimidinones as factor XIA inhibitors | |
AU2015221439B2 (en) | Crystalline 6,7-unsaturated-7-carbamoyl morphinane derivative, and method for producing same | |
MX361370B (en) | Dihydropyridone p1 as factor xia inhibitors. | |
PH12015501585A1 (en) | Manufacturing process for pyrimidine derivatives | |
WO2012138147A3 (en) | 1-(3-cyano-1-isopropyl-indol-5-yl)pyrazole-4-carboxylic acid crystalline form and the producing method thereof | |
SG179206A1 (en) | Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors | |
MX352470B (en) | Malonic acid di-salts and a method for preparing malonyl dihalides. | |
PH12015500160A1 (en) | Method of producing 4-[5-(pyridin-4-yl)-1h-1,2,4-triazole-3-yl]pyridin-2-carbonitrile, and intermediary thereof | |
NZ586187A (en) | Processes for the synthesis of sinomenine derivatives and their intermediate | |
CL2012000560A1 (en) | Preparation process of the intermediate compound 3-oxo-tetrahydrothiophene-2-carboxylic acid, useful in the preparation of dihydrothienopyrimidines (divisional of the application 3095-08). | |
MX2022001495A (en) | Novel processes for preparation of soluble guanylate cyclase stimulators. | |
JOP20180126A1 (en) | Novel processes for preparation of soluble guanylate cyclase stimulators | |
WO2011004387A3 (en) | Process for the preparation of dexlansoprazole polymorphic forms | |
MX2007013872A (en) | Process for production of 4-biphenylyazetidin-2-ones. | |
EA201001252A1 (en) | Method of producing derivatives of 3,6-dihydro-1,3,5-triazine | |
EA201300792A1 (en) | CHEMICAL COMPOUNDS | |
PL396539A1 (en) | Method for preparing new derivatives of 1-[(2-alkyl-2H-1 ,2,3-triazol-4-yl)methyl]pyrimidine-2,4(1H, 3H)-dione | |
IN2015DN03010A (en) | ||
EA201390016A1 (en) | METHOD FOR PRODUCING PIRANO DERIVATIVES [2,3-C] PYRIDINE | |
GEP20156350B (en) | New process for synthesis of ivabradine and their additional salts with pharmaceutically acceptable acid | |
EA201300650A1 (en) | SEPARATION OF TRIAZINE DERIVATIVE ENANTIOMERS WITH THE USE OF WINE ACID | |
PL396537A1 (en) | Method for producing a poly(alkylene terephthalate) of waste poly(ethylene terephthalate) | |
PL396538A1 (en) | Method for producing a poly(alkylene terephthalate) of waste poly(ethylene terephthalate) | |
PL396771A1 (en) | Process for the preparation novel derivatives E-2-amino-4-nitro-stilbene |