SU995791A1 - Method of treating psoriasis - Google Patents

Description

(54) METHOD FOR TREATING PSORIASIS

one

The invention relates to medicine, namely to the treatment of skin diseases - psoriasis.

There is a method of treating psoriasis by applying an solution of ammifurin to the affected areas of the skin and their subsequent ultraviolet irradiation 5.

However, in the treatment of this method possible adverse photobiological effects.

The purpose of the invention is to reduce side effects.

This goal is achieved by applying an ammifurin solution and subsequent ultraviolet irradiation to the affected area of the skin, after the solution dries, to apply ionol solution in concentration before irradiation.

Example 1. Patient M, 42 years old, suffers from a common blister form of psoria-2o for 8 years. Psychotic vials in the form of individual plaques on the elbows, knees, back and chest. 40 minutes before irradiation, a 0.3% solution of ammifurin is applied to the blisters with a brush, after drying the solvent (2-3 minutes), a solution of ional in ethanol at a concentration of 10 M is applied to the plaques on the right side of the body. The minimum erythemal dose (MED ) for skin areas with ionol equal to 3 min, without ionol -. 1.5 min The irradiation is carried out on the PUVA-22 facility, the radiation intensity is 8 J / cm, the emission spectrum is 320: 400 nm, and the intensity is greatest at a wavelength of 365 nm. Radiation was performed 3 times a week, bye to complete clinical recovery of the patient. By clinical recovery is meant the formation of a clean, even, elastic, slightly pigmented skin in place of the psoriatic plaque. Clinical recovery on the side of the body, where ionol is limped, was achieved as a result of 15 irradiation sessions (total dose of 195 min), on the side of the body without ionol, as a result of 25 irradiation sessions (total dose of 274 min). The use of ionol has reduced the number of procedures needed to cure a patient by 1.66 times, and the total dose - by 1.4 times.

Example 2. Ill Sh., 20 years. Ill for 4 years. The patches are located symmetrically on the elbows and the feet. DER with ionol is 2 minutes, without ionol - 1.5 minutes. The procedures were carried out analogously to example 1. As a result of using ionol, the number of procedures required for cure decreased 1.42 times, the total dose 1.12 times.

Example 3. Patient S., 17 years old, ill for 1 g. Separate plaques the size of a 3-kopeck coin are located on forearms x and elbows. DER with ionol is 3 minutes, without ionol - 1 min. A 0.3% solution of amfurin is applied to the plaques, and after drying the solvent, ionol is applied to the plaques of the right hand. Irradiation at the PUVA-4 facility (radiation intensity 6 J / cm, maximum emission at a wavelength of 365 nm) 4 times a week before complete clinical recovery, which on the side with ionol reached in 7 sessions, on the side without ionol - in 14 sessions.

The proposed method reduces the duration of treatment, reduces the range of side effects (erythema, pigmentation) without reducing the effectiveness of the treatment.

Claims (1)

Invention Formula A method of treating psoriasis by applying an ammifurin solution to the affected skin areas and their subsequent ultraviolet irradiation, characterized in that, in order to reduce side effects, after drying the solution, ionol at a concentration of 10 -10 M is applied to the affected skin area Sources of information taken into account during the examination 1. A. Kalamkar A. A. et al. The first experience of photochemotherapy of patients with psoriasis in the USSR- “Journal of Dermatology, 1979, No. 1, p. 7-12.