SU839543A1 - Method of treating patients ill with focal infections - Google Patents

Description

(54) METHOD FOR TREATING PATIENTS WITH FETAL INFECTIONS

The invention relates to medicine and can be used in the clinic in the treatment of focal infections.

Known method of treating patients with ochagic infections using oral administration of levamisole G

However, levamisole treatment is long-term (30-120 days) and side effects are possible that develop in almost 5-20% of patients.

The purpose of the invention is to reduce the duration of treatment and reduce the side effects.

This goal is achieved by levamisole applied directly to the lesion in a concentration of 0.001-0.01% 1-6 times a day for 3-14 days.

Example. Patient F., 13 years old, was admitted to the ENT Department with complaints of difficulty breathing through the nose, pain in the forehead, and muco-purulent discharge from the nose. More than 5 years of chronic bilateral purulent sinusitis. Every year, once or twice he took conservative treatment on an outpatient and inpatient basis, with sinus punctures and the introduction of

various antibiotics, hydrocartisone. Last seen on. inpatient treatment in the regional hospital at the place of residence. The treatment was not effective, it was sent for inpatient treatment.

A course of treatment with levs. Ash and morphocyclone was performed. Puncture, maxillary sinuses (only 8 to 4 s

Calsda side) is produced every other day. The maxillary sinuses are washed with a 0.01% solution of levomizol followed by the introduction of a solution of morocycline. After the treatment, the headaches disappeared, the nasal discharge stopped, breathing through the nose was restored. One month after the treatment on the R5 chart, there are no signs of inflammation of the hypospinal sinuses. To date, no recurrence of the disease has been observed.

Example 2. Patient hours, 23 years. He turned to a dental clinic with complaints of sharp pain in the area of the oral mucosa, impossibility of eating, removing mucous membranes, and bleeding on the lips.

The disease appeared when the patient felt a burning sensation and pain in the area of the oral mucosa. Bubbles appeared at some sites. I did not see a doctor.

When examining the oral cavity of the mucous membrane is hyperemic, edematous, teeth are imprinted on the tongue. In some areas there are extensive erosions, covered with a fibrinous-necro raid, lips covered with bloody crusts. General malaise, weakness, t - 37.4,

The diagnosis of exudative erythema multiforme.

Treatment prescribed: antihistamines, in / in a 10% solution of calcium chloride. Local -.- application of trypsin solution on a microcide, then applying a meta-paste. The treatment carried out for 5 days did not lead to a pronounced success. Epithelization was in the loy.

The treatment scheme was changed, which consisted in rinsing the oral cavity with a 1: 5000 furatsilin solution followed by lubricating the affected areas with an emulsion of a 0.01% solution of levamisbl 3-4 times a day

The next day, the patient's condition was dramatically improved, the pain disappeared, the tongue was cleared of plaque, the eroded areas were halved, some epithelialized. After 2 days, epithelization was complete.

Example 3. Patient K., 46 years old, suffers from chronic right-sided suppurative sinusitis for 5 years, repeatedly takes conservative treatment on an outpatient and inpatient basis with punctures of the right purulent sinus and washing it with various antiseptics, administration of the antibiotic hydrocortisone, chymotrypsin, a temporary effect.

Takes a course of treatment with levamisole. Difficult breathing through the nose, more to the right, headaches in the forehead, mucopurulent nasal lesions from the right half of the nose are worried during admission. Levamisole is treated. Puncture of the maxillary sinus is carried out every other day (4 in total) with washing with a 0.01% solution of levamisole. After the treatment, all the symptoms of the disease disappeared and there was no exacerbation of the disease until now.

The proposed method has been applied in the treatment of various types of antritis (purulent, hypoplastic, and polypous-purulent) of resistant antibacterial and anti-inflammatory drugs commonly used for this purpose.

Under the supervision there were 30 patients who had previously undergone almost all currently used conservative methods for the treatment of chronic sinusitis, who were offered the operation of sinusotomy.

Levamisole treatment is carried out as follows.

After the usual application of anesthesia with a 2-3% solution of dikain with the addition of a 0.1% solution of epinephrine, a patient of the maxillary sinus is punctured with the aid of a Kulikovsky needle, and the contents are sucked off. Then the sinus is washed with a 0.01% solution of levamisole. After that, 15,000 morfocycline units (group I) were injected into 15 patients in the sinus, 15 patients did not receive any more drugs (group II) except for levamisole. As a rule, punctures are performed every other day. 5 observations daily. It was enough to have 2-4 punctures in order to stop exudation in the maxillary sinus, to significantly improve the patient's well-being - headaches, nasmorski, general weakness, insomnia disappeared, normalized, basic physiological indicators.

Of the 30 people, only one did not receive the desired effect and, after preliminary preparation, he was given maxillotus.

The table shows the comparative results of the treatment by the known and proposed method.

Efficiency

70-90 treatment% 30-56

Duration of treatment

3-14

30-140 days

Side effects

5-20 No events,%

Course price le0, 2-4

22-25 rubles, rub

The proposed method allows to significantly reduce the time of treatment and completely avoid side effects.

Claims (1)

Invention Formula A method of treating patients with focal infections with the help of levamisole, characterized in that, in order to shorten the treatment time And reducing the side effect of levamisole is applied directly to the lesion in a concentration of 0.001-0.01% 1-6 times a day for 3-14 days. Sources of information taken into account in the examination l.Symoers J. Roseiital H.J. Reticnlaendothel Soc. 1977, 21.3. p. 175-221.