SU789112A1 - Method of treating children's extrasystolic arrhythmia - Google Patents

Description

one

The invention relates to medicine, namely to the treatment of cardiac arrhythmias.

There is a method of treating extrasystolic arrhythmias in children by administering potassium preparations, sedatives and antirhythmic substances. L.

However, the known method does not completely eliminate the persistent extrasystolic arrhythmia and the cure for long-term treatment (1 month).

The purpose of the invention is to reduce the time of treatment

This goal is achieved by adding 200-400 mg of etizol to the patient and 10-15 ml of lineetol daily for 14-16 days.

Examples of the method.

Example 1. A 9-year-old patient with persistent extrasystolic arrhythmia of unequal etiology, the treatment of which with antiarrhythmic therapy for 2 years by known methods did not eliminate the arrhythmia. On the electrocardiogram, extrasystoles of a pathological nature were found, emanating from the middle part of the atrioventricular node, 4 pathological signs of extrasystole were revealed: early extrasystoles; against the background of the main tachycardic rhythm - a pulse of 100 beats in the MHHj, the frequency of extrasystoles is 35%, there were ischemic types of change of the T wave and interval of ST.

From the beginning of inpatient treatment, the child received Panangin 1-2 tablets 3 times a day (at 8.14 and 18 hours), valerian extract 1-2 tablets

10 (0.01 g) 3 times a day (at 8, 14, 18 h), ascorbic acid (0.05 g)

2 times a day (at 8 and 18 h), calcium pangamat 1-2 tablets (0, 05 g)

3 times a day (at 8, 14 and 18 hours), about 15 ptins, 1-2 tablets (0.04 g) 4 times a day (at 8,12,16 and 20 hours), ethymisol (0.05 g) 4 times a day (at 8,12,16

and 20 hours), after a meal, limetol (10.0 ml) once a day (at 8 o'clock)

20 in the morning immediately before meals. The duration of the course of treatment with the aforementioned preparations by the above mentioned doses is 14 days.

The electrocardiogram of EI25 was evaluated by following the plasma lipid spectrum before treatment and two weeks after the course of treatment. ; After a two-week course of 30 treatments of the above method,

the child has disappeared extrasystolic arrhythmias, all the pathological signs of extrasystoles have also disappeared, shifts in the lipid spectrum of blood plasma have normalized. There were no side effects of drugs.

Example 2 A 14-year-old patient with persistent extrasystolic arrhythmia of unequal etiology (treatment of which with antiarrhythmic therapy by known methods for 3 years did not eliminate the arrhythmia). On the electrocardiogram. Extrasystoles of a pathological nature were found, emanating from the left ventricular ventricle. Three pathological findings were revealed: extrasystole signs: ventricular extrasystoles with a wide QRS complex of reduced amplitude; extrasystole frequency of 40%; there was an ischemic type of change of a tooth of T and an interval of ST.

From the beginning of inpatient treatment, the child received Panangin 1 tablet 3 times a day (at 8, 14 and 16 h) valerian extract 1 tablet (0.02 g) 3 times a day (at 8, 14 and 18 h), ascorbic acid (.0.1 g) 2 times a day (at 8 and 18 h), calcium pangamat 1 tablet (0.05 g) 3 times a day (8, 14. and 18 h), isoptin 1 tablet (0 , 04 g) 4 times a day (at 8, 12, 16 and 20 hours), etizol (0.1 g) 4 times a day (at 8, 12, 16 and 20 hours) after meals, lineetol 15.0 ml once a day (at 8 h) in the morning immediately before meals. The duration of treatment with the aforementioned preparations with the indicated doses is 16 days.

Electrocardiogram assessment and plasma lipid spectrum analysis were performed before treatment and two weeks after the course of treatment. After the course of treatment using the above method, the extrasystolic arrhythmia disappeared in the child. All pathological features of extrasystole also disappeared, and lipid spectrum shifts of plasma and blood were normalized. There were no side effects of drugs.

Example 3. Sick for 7 years with persistent extrasystolic arrhythmia of unsound etiology (treatment of which with known methods of antiarrhythmic therapy for 1 year and 8 months did not eliminate arrhythmia). Pathological extrasystoles were found on an electrocardiogram emanating from the upper part of the atrioventricular node (you There are three pathological signs of extrasystole: extrasystoles against the background of the main tachycardic rhythm, heart rate 120 beats per minute, extrasystole frequency - 22%, there was an ischemic type of T wave change and interval and ST.

From the beginning of inpatient treatment, the child received Panangin 1-3 tablets 3 times a day (at 8.14 and 18 hours) Valerian extract 1-3 tablets (0.02 g / 3) 3 times a day (at 8, 14 and 18 h), ascorbic acid (0.05 g) 2 times a day (at 8 and 18 h) calcium pangamat 1-3 tablets (0.05 g / 3) 3 times a day (8.14 and 18 h ), isoptin on 1-3 tablets (0.04 g / 3) 4 times a day (at 8, 12, 16 and 20 h), ethyzol (0.035 g) 4 times a day (at 8.12, 16 and 20 h) after meals, lineol 5.0 ml once a day (at 8 h) in the morning immediately before meals.

Electrocardiogram assessment and plasma lipid spectrum analysis were performed before treatment and two weeks after the course of treatment. After the course of treatment of the child in the above indicated manner, the extrasystolic arrhythmia did not disappear, only a decrease in the frequency of extrasystoles, as well as a decrease in the number of pathological signs of extrasystole were revealed. Changes in the lipid spectrum of blood plasma are not completely normalized.

The group of patients — 10 children with persistent extrasystolic arrhythmia of unequal etiology (treatment of which for 1-3 years by known methods of antiarrhythmic therapy did not eliminate extrasystolic arrhythmia, received only conventional treatment (potassium preparations — aE1angin or potassium phosphate; sedatives — valerian extract , antiarrhythmic drugs - g isoptin).

All of these drugs, patients received at the same time doses appropriate for age. The duration of the conventional course of treatment is four weeks. Among patients with group 1, the following were revealed: ventricular extrasystolic arrhythmias - in 5, atrioventricular - in 4, and atrial - in 1 child.

Group 1 - 20 identical patients with persistent extrasystolic arrhythmia of unequal etiology (treatment, which has been known for 1-3 years and methods of antiarrhythmic therapy did not eliminate extrasystolic arrhythmia) received conventional lamination (Kali Panangin or Potassium orotatate, sedatives - valerian extract anti-arrhythmic drugs isoptin) with simultaneous addition of aetizol and linetol, which actively influence lipid metabolism in order to shorten the treatment time and reduce complications.

Ethimisol was prescribed at 0.05 g (age of children from 7 to 10 years old), at 0.1 g (age of children from 11 to 14 years old) 4 times a day after meals. Linetol nazne

Chali 10 ml (age of children from 7 to 10 years), 15 ml (age of children from 11 to 14 years old) once a day on an empty stomach in the morning, just before the units. The course of treatment is two weeks.

Among children of group II, the following were revealed: ventricular extrasystolic arrhythmias - in 11, atrioventricular {en in 7, atrial - in 1, and mixed (ventricular and atrioventricular / 1 child).

In all children of groups I and II, extrasystolic arrhythmias had a pathological character — that is, from 1 to 5 pathological signs of extrasystoles were detected on the electrocardiograms of these children. The main pathological symptom - the frequency of extrasystoles in all examined children exceeded 10% of the frequency of extrasystoles was assessed in% when recording 100 cardiac systems in the II standard lead, the presence of pathological signs of extrasystoles was determined in all children before treatment and two weeks after the course of treatment. In addition, in all children, the lipid spectrum of blood plasma was determined by ultramicromethod thin layer chromatography before treatment and two weeks after the course of treatment.

In patients with T groups, after a course of generally accepted treatment, the number of pathological signs of extrasystoles did not change; shifts in the lipid spectrum of blood plasma were not revealed; found only a slight decrease in the frequency of extrasystoles, but the difference is not statistically significant.

In addition, in patients of group I, there were side effects of drugs

in 20% of children, inhibition of the conductivity of the atrioventricular system was found (atrioventricular block disappeared after taking the medication). .

In patients of group II (under the influence of a new method of treatment), the number of pathological signs of extrasystoles and the frequency of extrasystoles are statistically significantly reduced, and some altered plasma lipid spectrum parameters reach normal levels (the average lipid-free, choline-containing phosphatides, free cholesterol levels decrease). reflects the improvement in the use of the main bioenergetic myocardial substrate fatty acids). In addition, no adverse effect of the group II was detected in patients of group II STV.

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The proposed method allows to significantly shorten the treatment time from 4 weeks in a known manner to 2 weeks with the proposed one.

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Claims (1)

1. Volumes L. Heart rhythm disturbance, Sophie,. 1976, p. 333