SU1306581A1 - Method of treatment of extrasystologic arrhythmia - Google Patents

Abstract

This invention relates to medicine, more specifically to cardiology. The purpose of the invention is to prevent the side effects of antiarrhythmic drugs and shorten the treatment time by activating the lipid metabolism with cobamamide and prevent the increase in the level of lipid peroxidation of the lipid. To do this, patients with cardiac arrhythmia, along with the administration of potassium, sedative and antiarrhythmic drugs, daily intramuscularly administered cobamamide at a dose of 0.0005-0.001 mg and undevit at a dose of 1 / 2-2 pills after a meal 3 times a day. The course of treatment is 10-14 days. from € (L with about Oi ate 00

Description

The invention relates to medicine, namely cardiology.

The aim of the invention is to prevent the side effects of antiarrhythmic drugs and to shorten the treatment time by increasing the lipid metabolism of cobamamide and preventing the increase in the level of peroxide oxidation.

Example 1. Patient S., 6 years old with persistent extrasystolic heart arrhythmia associated with hypomotor dyskinesia of the gallbladder, whose treatment with known antiarrhythmic therapy for 2 years has not eliminated arrhythmia. On the electrocardiogram, polythonic supraventricular extrasystoles of a pathological nature, originating from the middle part of the atrioventricular node and atria, were found (4 pathological signs of extrasystodes were detected: frequency of extrusion 19%, ischemic type of T wave change and ST interval, polytonic extrasystoles, QT interval duration the extrasystolic complex transcends the QT of the normal cardiac cycle).

From the beginning of inpatient treatment, the child received; Panangin 1/3 tablet 3 times a day (at 9.14 and 8 h) after meals, valerian extract 1/3 tablet {0502g / 3) 3 times a day (at 9.14 and 18 h after meals, cordaron 1/3 tablet (U, 2 g / 3) 3 times a day (at 9.14 and 8 h) after a meal, bella-tamyl 1/3 tablets (20.4 mg) 3 times a day (at 9.14 and 18 hours) after meals and cobamamide 0.0005g intramuscularly 1 time per day (at 10 hours), as well as the multivitamin preparation, Undevit, containing, among other vitamins, vitamin E, with anti-alcohol effect, 1/2. pills 3 times a day (at 9.14 and 18 h after meals). The course of treatment is 10 days. An electrocardiogram was evaluated before, after treatment, after one, two, and weeks from the start of treatment. The determination of the level of the primary peroxide products, lipid oxidation — the jug of yugirovany dienes in the isopropyl phase of the blood serum was carried out before treatment and in its dynamics. After 7 days from the start of treatment, the systolic syrhythmia disappeared in the child. All the pathological signs of extrasystoles also disappeared. Side Effects of Drugs on the Digestive System

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there was no pathway (and others). The disappearance of the extrasystolic arrhythmia of the heart was accompanied by positive dynamics of the level of the primary products of lipid peroxidation of short-term blood. Before treatment, the index of conjugated dienes in the phase of isopropyl alcohol was found to be 12.7 and / ml (at a rate of 5.20 iO, 49 D / ml). After treatment, the concentration of conjugated dienes in the phase of serum isopropyl alcohol decreased to 4.26 D / ml.

Example 2. Patient M, 10 years with a flock of extrasystolic arrhythmia of the heart, with concomitant hypomotor dyskinesia of the gastric bladder. The use of known methods of antiarrhythmic therapy for 7 years has not eliminated arrhythmia. Extrasystoles of a pathological nature were found on the electrocardiogram, the outcome was from the left stomach (4 pathological signs of extrasystoles were revealed: extrasystoles frequency 37%, trigemini type alorrhythmias, QT duration of the extrasystolic complex exceeds QT of the normal cardiac cycle, there was an ischemic type of T wave change and ST interval). From the beginning of inpatient treatment, the child received: Panangin 1/2 tablet 3 times a day (at 9.14 and 18 h) after meals, valerian extract 1/2 tablet (0.01 g) 3 times a day (at 9, 4 and 18 hours after a meal, Cordaron 1/2 tablets (0.1 g) 3 times a day (at 9.14 and 18 hours) after a meal, Bellatamininal 1/2 tablets (0.2 g) 3 times a day (in 9.14 and 18 h) after meals and cobammand 0,00025 g intravenously 1 time per day (at 10 h) -, - as well as a multivitamin preparation Undet.vit, containing vitamin E with an anti-oxidative effect of 1 tablet 3 once a day (at 9.14 and 18 h after a meal. The course of treatment is 10 days.

Evaluation of the electrodes; ardiograms were carried out before treatment, one, two and four weeks after the start of treatment. When applying the proposed method, after 5 days from the start of treatment, the extrasystolic heart arrhythmia and all pathological signs of extrasystoles disappeared in the child. The side effect of medication on the part of the digestive tract is not. bsho The disappearance of persistent cardiac arrhythmia was accompanied by normalization.

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The level of primary products of serum lipid peroxide oxidation before treatment, the concentration of conjugated dienes in the isopropyl phase reached 17 D / ml (at a rate of 5.20 ± jiO, 49 D / ml), after treatment, the optical density index of conjugated dienes in the isoprothyl phase per milliliter of blood flush was in the normal range (6.8 D / ml).

Example 3. Patient M., aged 14, with persistent cardiac rhythm disturbance associated with hypomotor dyskinesia of the gallbladder. Treatment of arrhythmias (atrioventricular dissociation with supraventricular extrasystoles) for 4 years did not eliminate the disruption of the heart rhythm. On the electrocardiogram, extrasystoles of a pathological nature were found, proceeding from the middle part of atrioventricular dissociation, 3 pathological signs of extrasystoles were revealed: the frequency of extrasystoles was 20%;

cheni. After 4 days from the start of treatment, the persistent heart rhythm disturbance disappeared, as well as all the pathological signs of extrasystoles. There were no side effects of drugs on the part of the digestive tract.

Positive clinical dynamics was accompanied by normalization of the level of primary products of serum lipid peroxidation: before treatment, the concentration of conjugated dienes in the isopropyl alcohol phase was 18.6 D / ml (at a rate of 5.20 + 49 D / ml), after treatment, it decreased to 5, 2 D / ml.

The proposed method of treatment completely eliminates the side effect of antiarrhythmic drugs on the part of the digestive tract, shortens the time of treatment for persistent extrasystolic heart arrhythmia in children, accompanied by hypomotor dyskinesia of the gall bladder; in all patients (treatment of which during

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tazykardicheskogo rhythm pulse 100 beats./25 1-7 years old by ancient means antiarimina, early extrasystoles).

From the beginning of inpatient treatment, the child received: Panangin 1 tablet 3 times a day (at 9.14 and 18 hours) after meals, Valerian extract 1 tablet 3 times a day (at 9.14 and 18h) after meals, cardarone 1 3 tablets per day (at 9.14 and 18 hours) after meals, bellamininal 1 tablet 3 times per day (at 9.14 and 18 hours) after meals, cobamamide, 0.001 g, 1 time per day (at 10h ) intramethropic and multivitamin preparation Undevit containing vitamin E, 2 pills 3 times each of the ratmic therapy did not eliminate the heart rhythm disorder) arrhythmias were stopped completely within 7 days.

Claims (1)

30 claims A method for treating an extrasystolic cardiac arrhythmia in children by administering potassium, sedative, 35 antiarrhythmic drugs and bellaminal drugs, which, in order to prevent the side effects of antiarrhythmic drugs and shorten the treatment time per day (9.14 and 18 hours) after food. 40 neither at the same time in the morning Koba is administered daily intramuscularly. An electrocardiogram of provamamide at a dose of 0.0005-0.001 g and undead {1c before treatment, one later, turns at a dose of 1 / 2–2 pills after eating 3 two and four weeks PS5 after the course of le-times per day for 10-14 days. Or M.Klelemes 1478/5 Compiled by L.Solovyov Tehred I.Popovich Cor Pod Circulation 596 VNISHI USSR State Committee Inventions and discoveries 113035, Moscow, L (-35, Raushsk nab. 4/5 Production and printing company, Uzhgorod, Projecto st., 4 sh - 15 065814 cheni. After 4 days from the start of treatment, the persistent heart rhythm disturbance disappeared, as well as all the pathological signs of extrasystoles. There were no side effects of drugs on the part of the digestive tract. Positive clinical dynamics was accompanied by normalization of the level of primary products of serum lipid peroxidation: before treatment, the concentration of conjugated dienes in the isopropyl alcohol phase was 18.6 D / ml (at a rate of 5.20 + 49 D / ml), after treatment, it decreased to 5, 2 D / ml. The proposed method of treatment completely eliminates the side effect of antiarrhythmic drugs on the part of the digestive tract, shortens the time of treatment for persistent extrasystolic heart arrhythmia in children, accompanied by hypomotor dyskinesia of the gall bladder; in all patients (treatment of which during 20 1-7 years old by antiarizing methods tmicherapy did not eliminate the heart rhythm disturbance) arrhythmias were stopped completely within 7 days. Invention Formula A method for treating extrasystolic arrhythmias of the heart in children by administering potassium, sedative, antiarrhythmic and bellamina drugs, characterized in that, in order to prevent the side effects of antiarrhythmic drugs and shorten the terms, the corrector T. Kolb Subscription