SU789109A1 - Method of treating children's active rheumatism - Google Patents

Description

one

The invention relates to medicine and the treatment of active rheumatism in children.

A method for treating active rheumatism in children is known by administering 5 antibiotics of the penicillin group, acetylsalicylic acid and prednisolone p. .

However, during treatment in a known manner, the activity of the rheumatic process is slowly eliminated. Even after the first attack of the disease, 17-18% of children develop heart defects, and disorders of metabolic processes in the myocardium remain, associated not only with the pathological process, but also with the side effects of drugs.

The purpose of the invention is the prevention of complications.

This goal is achieved by additionally adding glevenol daily for 3–4 weeks.

The method is carried out as follows.

At the beginning of inpatient treatment, penicillin is administered intramuscularly for 10-14 days to the child, then, after the expiration of this time, injections are given every 5-7 days. Q

bitsillina-3. Acetylsalicylic kis. Sweat (starting from 0.20 g per year of life of the child and reducing the initial dose every 10-14 days by 0.50, 25 g), antihistamine drugs (diphenhydramine, pipolfen, suprastin, changing them every 10- 24 days), corticosteroid hormones (50% of children receive prednisone, starting with a dose of up to 1 mg per kg of body weight, and then reducing the initial dose by 2.5 mg in 7 days) and ascorbic acid are administered into the body from the start of treatment and continue their administration throughout the entire course of treatment. Additionally, from the very first inpatient treatment days, during or after a meal, glevenol is administered with the following doses: children of 6–12 years old, 400 mg once a day, children of 1315 years, 400 mg twice a day. Patients receive the drug for 30 days.

Example 1. A 10-year-old patient with rheumatic activity of the II degree, signs of myocarditis and circulatory insufficiency of the I degree from the beginning of inpatient treatment receives intramuscular injections of penicillin 500,000 units 4 times a day {at 8, 12,16 and 20 h), acetylsalicylic acid 2.5 g per day. (at 0.75 g at 8.13 and 18 hours), dimedrol at 0.02 g twice a day (at 8 and 18 hours), glevenol 400 mg once a day (at 14 hours - during lunch ascorbic acid acid 0.5 g 2 times a day (at 8 and 18 hours). After 10 days penicilli injections are not replaced by weekly injections of bitsillin-3 (600.000 units each) the dose of acetylsalicylic acid is reduced to 2 g per day. 1g per 13 and 18 h), the dose of ascorbic acid is reduced to 0.75 g per day (0.25 g per 8.13 and 18 h), dimedrol is replaced with pipolphene 0.025 g per day (1/2. tablets at 8 and 18 h.) The patient continues to receive Glevenol with the same doses as at the beginning of the treatment. For 10 days, the dose of acetylsapicilic acid is reduced to 1.5 g per day (0.5 g at 8.13 and 18 h). Pipolfen is replaced by suprastin of 0.025 g per day (1/2 tablet at 13 and 18 h) The rest of the drugs (bicillin-3, glivenol, ascorbic acid) are given to the patient in the following doses. The studies are carried out at the beginning of treatment and 30 days after its beginning. Example 2. Patient 14 years old with a rheumatic process of grade III, relapsing a current with polyarthritis and endomyocarditis (affection of mitral valves), with insufficiency of blood circulation of I degree from the beginning of the Treatment receives intramuscular injections of penicillin 500,000 4 times a day (at 8,12,16 and 20 h), acetylsalicylic acid, 3,0 per day. (1.0 g at 8.13 and 18 h), dimedrol at 0.03 g twice a day (at 8 and 18 h), prednisolone at 0.015 (3 tablets) 3 times a day (at 8, 11, and 14 h), 3% solution of potassium chloride 15 ml 3 times a day (at 8.13 and 18 h) ,. Glevenol 400 mg 2 times a day (during breakfast at 9 h, and during lunch at 14 h), ascorbic acid 0.5 g 2 times a day (at 8 and 18 h), After 7 days, the dose of prednisolone is reduced 0.005 g (1 tablet) and since then the prednisone patient receives 0.015 g at 8 and at 11 h and 0.01 g at 13 h. After 10 days from the start of treatment, penicillin injections are replaced with weekly intramuscular injections of bicillin-3 ( 600.000 units; a daily dose of acetylsalicylic acid is reduced by 0.5 g (0.5 each at 8 hours and 1.0 g each at 13 and 18 hours). The ascorbic acid dose is reduced to 0.70 g per day. (O, 35 g in 8 and 18 h), Dimedrol replaced with pipolfen (at 0.025 g twice a day (at 8 and 18 h). The dose of glevenol remains the same. After 14 days from the start of treatment, the dose of prednisolone decreases by another 0.005 g (at 0.015 g at 8 h and 0.01 g at 11 and 14 h), 20 days after the start of treatment, the dose of acetylsalicylic acid after another decrease of 2.0 g per day (0.5 g at 8 and 13 h, and 1.0 g at 18 h). Pipolfen is replaced with suprastinam (0.025 g at 8 and 18 h), the dose of prednisone is reduced again by 0.005 g (at 0.01 g at 8.11 and 14 h). After 25 days, after another decrease in the dose of prednisolone by 0.005 g, the patient receives it at 0.01 at 8.11 and 0.005 g at 14 h. After 30 days from the start of treatment, repeated studies are carried out. The proposed method provides a fast extinction of the activity of the rheumatic process, as evidenced by a more noticeable normalization of erythrocyte sedimentation rate, protein fractions in the blood serum and a more pronounced decrease in antistreptolysin titer (see Table 1). Treatment with glevenod has a positive effect on the metabolism of the connective tissue (the total amount of hydroxyproline in the blood serum is reduced), changing the state of which is one of the main mathematical units of the rheumatic process (see Table 2). The method contributes to a more rapid electrolyte recovery. balance, first of all, normalization of the content and distribution of potassium and sodium (see Table 3). Under the influence of treatment with the addition of glivenol, hemodynamic indices normalized more quickly. Blood pressure normalized in 87% of all altered cases, the blood filling of the eye vessels significantly improved, 61% of altered cases normalized the pulse wave velocity in muscle type vessels. The proposed method has a positive effect on the improvement of heart tones, and thus on their ratio. Improved cardiac tones were found in 56% of patients with altered indices, and the tone ratio improved or normalized in 73% of children with altered indices, and altered cardiographic indices recovered more quickly, primarily indicators reflecting the percentages of myocardial depolarization.

Changes in erythrocyte sedimentation rate and antistreptolysin-O titer in children with active rheumatism, under the influence of various treatments

Table

Note. & tab. 1-3

A - indicators before treatment B - indicators after treatment.

Changes in the content of total hydroxyproline in the serum (µg / ml) and in the daily urine (mg / 24 h) in children with active rheumatism, under the influence of various treatment methods.

Table

ten

P

9.6

M

0.9

-J: m

R

Changes in the content of electrolytes in the plasma and erythrocytes of the blood (Jaqu / l) in children with active rheumatism, under the influence of various treatment methods

Continuation of table 2

ten

ten

82.5

68,8

13.1

7,8

Table E

Claims (1)

Claim, A method of treating active rheumatism in children by introducing antibiotics of the penicillin group, acetylsalicylic acid and prednisolone, characterized in that, VNIIPI Order 8920/3 in order to prevent complications; additionally, for 3–4 weeks, glivenol is administered daily.