SU715575A1 - L-3-(beta-phenylisopropyl)-n-phenylcarbamoylsidnoimine possessing psychostimulating activity - Google Patents

L-3-(beta-phenylisopropyl)-n-phenylcarbamoylsidnoimine possessing psychostimulating activity Download PDF

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Publication number
SU715575A1
SU715575A1 SU762423787A SU2423787A SU715575A1 SU 715575 A1 SU715575 A1 SU 715575A1 SU 762423787 A SU762423787 A SU 762423787A SU 2423787 A SU2423787 A SU 2423787A SU 715575 A1 SU715575 A1 SU 715575A1
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SU
USSR - Soviet Union
Prior art keywords
phenylisopropyl
phenylcarbamoylsidnoimine
possessing
beta
activity
Prior art date
Application number
SU762423787A
Other languages
Russian (ru)
Inventor
Леонид Ефимович Холодов
Роальд Абрамович Альтшулер
Владимир Генрихович Яшунский
Михаил Давыдович Машковский
Original Assignee
Всесоюзный Научно-Исследовательский Химико-Фармацевтический Институт Им.С.Орджоникидзе
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Всесоюзный Научно-Исследовательский Химико-Фармацевтический Институт Им.С.Орджоникидзе filed Critical Всесоюзный Научно-Исследовательский Химико-Фармацевтический Институт Им.С.Орджоникидзе
Priority to SU762423787A priority Critical patent/SU715575A1/en
Priority to CA284,999A priority patent/CA1097659A/en
Priority to DE19772738022 priority patent/DE2738022A1/en
Priority to FR7726079A priority patent/FR2372160A1/en
Priority to JP11063877A priority patent/JPS5365880A/en
Application granted granted Critical
Publication of SU715575A1 publication Critical patent/SU715575A1/en

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Description

„1"one

Изобретение относитс  к новому химическому соединению - производному сиднонимина, а именно к -3-(ji-фенилизопропил) -N-фенилкарбамоилсиднонимину формулы 1This invention relates to a novel chemical compound derived from sydnonimine, namely to -3- (ji-phenylisopropyl) -N-phenylcarbamoyl sidnonimine of formula 1

CHj .CHj.

II

едвЕ-- Ш just----

который обладает психостимулирующей активностью и может найти применение в медицине,- , which has psychostimulating activity and can be used in medicine, -,

Названное соединение  вл етй  новым и в литературе не описано.The named compound is new and is not described in the literature.

Среди производных сиднонимина найден р д веществ, примен ющихс  в качестве лекарственных препаратов. Среди них 3-)5-(фенилизопропи.л)-N-фенилкарбамоилсиднонимин (сйднокарб ) , нашедший применение в медицине в качестве активного стиму.л  топа центральной нервной системы lO. Это вещество  вл етс  рацемагом , Известны случаи, когда враце мате действующим началом  вл етс  один из оптически активных изомеров, а другой изомер малоактивен или практически не активен, в этом случав получение активного изомера в чистом виде позвол ет создать новое, более активное лекарственное вещество .Among the derivatives of sydnonimine, a number of substances have been found that are used as drugs. Among them, 3-) 5- (phenylisopropyl. L) -N-phenylcarbamoylsidnonimine (sydnokarb), which has found application in medicine as an active stimulator of the central nervous system lO. This substance is a racemag. There are cases where the active principle is one of the optically active isomers and the other isomer is inactive or practically inactive, in which case the preparation of the active isomer in its pure form allows you to create a new, more active drug substance.

Целью изобретени   вл етс  рас0 ширение арсенала средств,- обладающих психостимулирующей активностью.The aim of the invention is to expand the arsenal of means having psychostimulating activity.

Поставленна  цель достигаетс  6-3-(Ь-фенилизопропил)-N-фенилкарбамоилсиднонимином формулы 1, обладаю5 щим психостимулирующей активностью.This goal is achieved by 6-3- (b-phenylisopropyl) -N-phenylcarbamoyl ssnonimine of formula 1, which has a psychostimulating activity.

фармакологическое изучение 6-сиднокарба в опытах на мышах показало, что он оказывает действие, свойственное психостимул торам.A pharmacological study of 6-sydnocarb in experiments on mice showed that it has an effect characteristic of psychostimulants.

00

Изучение препарата проводилось в опытах на мышах- самцах весом 18-20 г п.о показател м, характеризующим активность психостимулирую .щих препаратов.The study of the drug was carried out in experiments on mice-males weighing 18-20 g pp indices characterizing the activity of psychostimulant drugs.

5five

Изучали способность усиливать рефлекторную возбудимость животных на применение тактильных раздражителей (стру  воздуха, направленна  из шприца на животное), способность We studied the ability to enhance the reflex excitability of animals to the use of tactile stimuli (a stream of air directed from a syringe to an animal), the ability

0 усиливать локомоторную активность.0 enhance locomotor activity.

Claims (1)

.Формула изобретения.Claim Е-З-ф~Фенилизопропил)-N-фенилкарбамоийсиднонимин формулы I * <iHj μΧ/\’ <^5^2 ' г<?еК-ν^Ζ.6=Ν-(5-ΝΗ д) иE-Z-f ~ Phenylisopropyl) -N-phenylcarbamoysidononymin of the formula I * <iHj μ Χ / \ '<^ 5 ^ 2' g <? EK-ν ^ Ζ.6 = Ν- (5-ΝΗ d) О ' обладающий психостимулирующей активностью.’O 'with psycho-stimulating activity. ’
SU762423787A 1976-11-25 1976-11-25 L-3-(beta-phenylisopropyl)-n-phenylcarbamoylsidnoimine possessing psychostimulating activity SU715575A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
SU762423787A SU715575A1 (en) 1976-11-25 1976-11-25 L-3-(beta-phenylisopropyl)-n-phenylcarbamoylsidnoimine possessing psychostimulating activity
CA284,999A CA1097659A (en) 1976-11-25 1977-08-18 Sydnonimine n-acylderivatives and method for preparing same
DE19772738022 DE2738022A1 (en) 1976-11-25 1977-08-23 N-AZYL DERIVATIVES OF SYDNONIMINE AND PROCESS FOR THE PREPARATION
FR7726079A FR2372160A1 (en) 1976-11-25 1977-08-26 Psycho-stimulant (N)-acyl-3-phenyl or phenethyl-sydnone imine derivs. - prepd. by reacting (N)-nitroso-amino-acetonitrile derivs. with an acylating agent
JP11063877A JPS5365880A (en) 1976-11-25 1977-09-16 Cydononeimineeacyl derivative and process for preparing same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU762423787A SU715575A1 (en) 1976-11-25 1976-11-25 L-3-(beta-phenylisopropyl)-n-phenylcarbamoylsidnoimine possessing psychostimulating activity

Publications (1)

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SU715575A1 true SU715575A1 (en) 1980-02-15

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2807361C1 (en) * 2023-10-06 2023-11-14 Леонид Ефимович Холодов Method for obtaining levorotatory stereoisomer ln-phenylcarbamoyl-3(β-phenylisopropyl)sydnonimine, l-sydnocarb

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2807361C1 (en) * 2023-10-06 2023-11-14 Леонид Ефимович Холодов Method for obtaining levorotatory stereoisomer ln-phenylcarbamoyl-3(β-phenylisopropyl)sydnonimine, l-sydnocarb

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