RU94045930A - Proteins, dna, vector, cell, methods of preparing and purification of protein, pharmaceutical composition - Google Patents

Proteins, dna, vector, cell, methods of preparing and purification of protein, pharmaceutical composition

Info

Publication number
RU94045930A
RU94045930A RU94045930/13A RU94045930A RU94045930A RU 94045930 A RU94045930 A RU 94045930A RU 94045930/13 A RU94045930/13 A RU 94045930/13A RU 94045930 A RU94045930 A RU 94045930A RU 94045930 A RU94045930 A RU 94045930A
Authority
RU
Russia
Prior art keywords
protein
dna
proteins
purification
vector
Prior art date
Application number
RU94045930/13A
Other languages
Russian (ru)
Other versions
RU2128705C1 (en
Inventor
Неске-Юнгблут Кристиане
De]
Хэндлер Бернхард
Крэтцшмар Йерн
Fr]
Шлойнинг Вольф-Дитер
Алагон Алехандро
Домингос Поссани Луриваль
Анатолиа Кевас-Агирре Делиа
Mx]
Original Assignee
Шеринг АГ (DE)
Шеринг Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Шеринг АГ (DE), Шеринг Аг filed Critical Шеринг АГ (DE)
Publication of RU94045930A publication Critical patent/RU94045930A/en
Application granted granted Critical
Publication of RU2128705C1 publication Critical patent/RU2128705C1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Insects & Arthropods (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

FIELD: molecular biology. SUBSTANCE: invention relates to protein that inhibits collagen-induced platelet aggregation. Protein and its derivatives were prepared from Triatoma pallidipennis. This protein is used as drug for inhibition of collagen-induced human platelet aggregation or for cancer diseases treatment with metastatic tumor cells. EFFECT: enhanced effectiveness of treatment.

Claims (1)

Изобретение относится к протеину, который ингибирует вызываемую коллагеном агрегацию тромбоцитов, полученному из Triatoma pallidipennis^ и его производным. Этот протеин используют в качестве лекарства для ингибирования вызываемой коллагеном агрегации тромбоцитов человека или лечения раковых заболеваний с метастатическими опухолевыми клетками.The invention relates to a protein that inhibits collagen-induced platelet aggregation obtained from Triatoma pallidipennis ^ and its derivatives. This protein is used as a medicine to inhibit collagen-induced aggregation of human platelets or to treat cancer with metastatic tumor cells.
RU94045930A 1991-09-05 1992-09-04 Protein inhibiting collagen-caused aggregation of mammalian platelets, recombinant protein inhibiting collagen-caused aggregation of platelets, dna fragment encoding recombinant protein, expression vector (variants), strain of cultured mammalian cells bhk - producer of recombinant protein (variants), method of preparing recombinant protein, pharmaceutical composition RU2128705C1 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US75621191A 1991-09-05 1991-09-05
US07/756211 1991-09-05
US81488491A 1991-12-31 1991-12-31
US07/814884 1991-12-31
US91438392A 1992-07-17 1992-07-17
US07/924,383 1992-07-17
US07/924383 1992-07-17
PCT/EP1992/002052 WO1993005150A1 (en) 1991-09-05 1992-09-04 Collagen-induced platelet aggregation inhibitor

Publications (2)

Publication Number Publication Date
RU94045930A true RU94045930A (en) 1996-07-20
RU2128705C1 RU2128705C1 (en) 1999-04-10

Family

ID=27419489

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94045930A RU2128705C1 (en) 1991-09-05 1992-09-04 Protein inhibiting collagen-caused aggregation of mammalian platelets, recombinant protein inhibiting collagen-caused aggregation of platelets, dna fragment encoding recombinant protein, expression vector (variants), strain of cultured mammalian cells bhk - producer of recombinant protein (variants), method of preparing recombinant protein, pharmaceutical composition

Country Status (16)

Country Link
EP (1) EP0530937B1 (en)
JP (2) JPH07506959A (en)
KR (1) KR100232683B1 (en)
AT (1) ATE169674T1 (en)
AU (1) AU672584B2 (en)
CA (1) CA2117174A1 (en)
DE (1) DE69226580T2 (en)
DK (1) DK0530937T3 (en)
ES (1) ES2121817T3 (en)
FI (1) FI112801B (en)
HU (1) HU218830B (en)
IL (4) IL103065A (en)
NO (1) NO314848B1 (en)
NZ (1) NZ244246A (en)
RU (1) RU2128705C1 (en)
WO (1) WO1993005150A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10505502A (en) * 1994-09-12 1998-06-02 シェーリング アクチェンゲゼルシャフト Preparation of modified collagen-induced platelet aggregation inhibitor paridipine
GB2304048A (en) * 1995-08-12 1997-03-12 John William Carson Medicament containing saliva extract
JP3837518B2 (en) 2002-10-02 2006-10-25 国立大学法人三重大学 Ti-4 protein derived from Brazilian sand turtle having platelet aggregation inhibitory activity
JP3837519B2 (en) 2002-10-02 2006-10-25 国立大学法人三重大学 Ti-3 protein derived from Brazilian sand turtle having platelet aggregation inhibitory activity
AU2003227721A1 (en) * 2003-05-02 2004-11-23 Paion Gmbh Intravenous injection of non-neurotoxic plasminogen activators for the treatment of stroke
CA2522989A1 (en) * 2003-05-21 2004-12-02 Ares Trading S.A. Method of chromatographic analysis of a protein solution
EP1760092A1 (en) * 2005-08-26 2007-03-07 Applied Research Systems ARS Holding N.V. System for screening cells for high expression of a protein of interest
US7691839B2 (en) 2005-09-28 2010-04-06 Biovascular, Inc. Methods and compositions for blocking platelet and cell adhesion, cell migration and inflammation
JP5332178B2 (en) * 2007-11-02 2013-11-06 東洋紡株式会社 Method for detecting multicolor luciferase
JP5747370B2 (en) * 2009-03-31 2015-07-15 国立大学法人浜松医科大学 Highly sensitive detection method for highly pathogenic oral bacteria
CN109125355B (en) * 2018-08-03 2022-07-08 昆明医科大学第一附属医院 Psychopharmacology application of Xinmailong for anti-platelet and anti-thrombus
CN112354570B (en) * 2019-07-11 2022-02-11 北京理工大学 Multidimensional microfluidic electrophoresis chip, detection device and detection method

Also Published As

Publication number Publication date
KR100232683B1 (en) 1999-12-01
HU9400662D0 (en) 1994-06-28
FI941052A (en) 1994-03-04
IL119492A0 (en) 1997-01-10
IL103065A (en) 2001-11-25
HU218830B (en) 2000-12-28
NO314848B1 (en) 2003-06-02
HUT70271A (en) 1995-09-28
NO940771D0 (en) 1994-03-04
IL103065A0 (en) 1993-02-21
RU2128705C1 (en) 1999-04-10
ES2121817T3 (en) 1998-12-16
WO1993005150A1 (en) 1993-03-18
EP0530937B1 (en) 1998-08-12
DK0530937T3 (en) 1999-05-10
IL119491A (en) 2000-11-21
JP2003313199A (en) 2003-11-06
NZ244246A (en) 1994-03-25
AU672584B2 (en) 1996-10-10
CA2117174A1 (en) 1993-03-18
IL119491A0 (en) 1997-01-10
JPH07506959A (en) 1995-08-03
AU2502292A (en) 1993-04-05
FI941052A0 (en) 1994-03-04
NO940771L (en) 1994-03-04
DE69226580T2 (en) 1999-03-04
ATE169674T1 (en) 1998-08-15
DE69226580D1 (en) 1998-09-17
EP0530937A1 (en) 1993-03-10
FI112801B (en) 2004-01-15

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Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20050905