SU707503A3 - Additive to fodder for poultry - Google Patents

Description

(54) FEED SUPPLEMENT FOR HOME

. . :: bird

-. , - .. ..

This invention relates to feed additives for poultry to help accelerate their growth; Various additives for poultry are known, containing biologically active synthesized organic compounds and carriers 1 in the form of an inert substance, dispersant or feed substance 1,

However, when using known additives, significant amounts of biologically active substances are often consumed and they do not always have an effective effect on the organism of animals.

The aim of the invention is to expand the range and improve the efficiency of feed additives for poultry, contributing to the growth of their growth and are harmless to them,

This goal is achieved by the fact that the proposed additive as a biologically active. substances use 3-imino-1,2,4-benzotriazin-1-oxide of the general formid - -

Y-VAH-

odflu

where R is C-C d-alkyl, substituted by lower a lk yl, halogen or halogen by lower alkyl benzoyloxy;

X and Y are hydrogen, alkyl or alkoxy of 1 to 3 carbon atoms, phenoxy or phenylsulfonyl,

in the amount of 0.0001-0.05% by weight

carrier.

Compounds of formula (1) are prepared

the interaction of the 3-amin-1,2,4-benetriazin-1, 4-di-K-oxide of the formula (11)

15

in a solvent or diluent with a carboxylic acid halide of the formula (III)

R - CO - NAY

where R is as defined above, and the reaction is carried out in the presence of an acid acceptor or with a corresponding R value of a linear or branched carboxylic anhydride,

As the reaction medium, inert with respect to the reactant components are used solvents, and / or l and ra 3 b gHGHITCHI, among which may be aromatic hydrocarbons, for example benzene, toluene, xylene; halogenated hydrocarbons, for example chlorobenzene, chloroform, carbon tetrachloride; ethers and ether-like compounds, such as dialkyl ethers and cyclic ethers, for example, dioxane; ketones - acetone, methyl ethyl ketone; see these similar solvents with each other or with water (two-phase systems, and in particular, a mixture of methyl ethyl ketone and water). Both inorganic and organic bases can be used as an acid acceptor, and among the inorganic bases, hydrochloric acid and alkali metal hydroxides are most preferred. Under the organic basis: first of all, you should understand the third yyg ainu, natfimer, pyridine or Shridinovye bases and trialkylamines, for example, triethylamine. Among carboxylic acid halides, acid chlorides and bromoanhydrides are preferred; in the case of using anhydrides, monocarboxylic acid anhydrides, for example; acetic, propionic, butyric, and also anhydrides of the corresponding halogenated alkanecarboxylic acids. In the examples given below, the method for preparing some compounds of formula (1) is explained. Example 1. H-Imino-4-acetone si-1,2,4-benztriazin-1-oxide. 17.8 g of 3-amino-1,2,4-benztriazine -1,4-di-N-oxide is dissolved with 200 ml of glacial acetic acid, "To the prepared solution is added dropwise 15.3 g anhydride of acetic acid and immediately after that the reaction mixture is stirred for 3 hours at. Then. the reaction civtecb o. is cooled, the yellow-colored D1 ~ sediment is filtered off, the npoMMBjiior is washed and dried under vacuum. Aux. GH. TeiM.p. melting point 194-19b Example 2. 3-Imino-4-benzyl-1-oxylate; 2,4-benztriazin-1-oxide. .13.5 C-amino-1,2,4-benztriazin-1, 4-di-N-hydroxide and 45.2 g of benzoic anhydride are dissolved at room temperature in 75 ml of acetic acid triple and immediately thereafter the reaction mixture stirred for 3 h at. Then, the reaction syoesi de1b vyzs with cool to room temperature, pour it into 200 ml of water and rtfil. Liv this painted yellow color solid 6. Pstat was peremegaivat in 25 ml of glacial acetic acid at 45c, filtered and washed with ipp. then tub in a vacuum. The melting point of the product obtained is 177-179 ° C. The following 1bm, no compound is obtained by taxing with the method described in reamers: 1) 3-imino-4-propionyloxy-7-methoxy-1; 2,4-benztriazin-1-oxide; m.p. 81-183 ° C; 2) 3-imino-4-capr. Oryloxy-7-methoxy-1, 2,4-benztriazin-1-oxide, so pl. (different); 3) 3-imino-4-crotonyloxy-7-methyl-1,2,4-benztriazIn-1-oxide, t. Pl. 02-204 C; 4) 3-imino-4-acetoxy-7-methyl1, 2,4-benztriazin-G-oxide, t, pl. 19b-197C; 5) 3-imino-4- (4-chlorobenzoyloxy) 1, 2,4-benztriazin-1-oxide, mp; 6) 3-imino-4- (2,4-dichlorobenzoyl) -1,2, 4-benztriazin-1-oxide, so pl. 10-214С; 7) 3-imino-4- (4-methyl-benzoyloxy), 2,4-benztriazin-1-oxide, m.p. 158-1b1 C; 8) 3-imino-4-lauroyloxy-1,2,4-benztriazin-1-oxide, so pl. 158-161 C; 9) .. 3-amino-4-lauroyloxy-1,2, 4-benztriazin-1-oxide, so pl. WITH; 10) 3-imino-4- (3-trifluoromethyl-benzoyloxy) -1,2,4-benztriazin-1-oxide, m.p. 173-17 b ° C; . 11) 3-imino-4-acetoxy-7-phenoxy-1; 2,4-benztriazin-1-oxide; m.p. 177 -180С; . 12) 3-imino-4-acetoxy-b-phenylsulfonyl-1, 2 4-benztriazin-1-oxide, t, mp, 207-209С; . 13). 3-imino-4-chloroacetoxy-1,2,4-benztry-azin-1-oxide, so pl. 142- .. The compounds of formula (1) have a stimulating effect on bird growth. They are added to the feed or drink for birds in the amount of 0.0002-0.05% by weight of filler. For economic reasons, the cultivation of poultry should be carried out as short as possible. By the time it costs the least expenditure of the crm, while receiving the maximum amount of meat and eggs. For this purpose, various feed additives are used. When compounds of formula (1) are used as a biologically active substance for growth-stimulating feed additives, these compounds can be combined, for example, with antibiotics, sulfoamides, nitrofurans, diaminopyramidines, oxyquinols, HaivM, vitamins and the like. In addition, the proposed feed additive may contain kaolin, lime, alumina, crushed shells, white Yolus, aerosil,

starch or lactose. To obtain a feed additive, the required amount of the premix (Premix) of these components is thoroughly mixed with the corresponding one. the amount of normal commercial standard feed.

Groups of 10 birds are used to study individual compounds of formula (1) and to reveal their optimal concentration. Compounds are used in concentrations of 20 and 100 hours. At

707503

1 million hours stern. The duration of the experiment is 28 days. Birds are kept in cellular batteries. For the experience take chickens of one day old. An appropriate amount of a compound of formula (1) is added to the feed of experimental birds; control birds receive the same feed, but without the addition of these compounds.

The average statistical values of the results are given in

0 table.

As can be seen from the table, the proposed feed additive with a compound of formula (1) has an effective stimulating effect on the growth of poultry.

The feed additive is either directly mixed with the carrier material, or applied as a solution, for example in chloroform, onto a substance, 65 carrier, after which the mixture is crushed to. obtaining particles of the desired size, for example, from 5 to 10 microns. The prepared feed mixture is processed from 5800, weight, hours, drinking water. In addition, this feed mixture can be granulated with 6000 parts by weight. for the preparation of cold granules.

Claims (1)

1. Patent of the USSR. No. 353379, cl. And 23 K 1/16, publ. 1972.