SU692604A1 - Preparation for treating salmonollosis, collibacillosis, gastroenterocolitis of microbe etiology - Google Patents

Description

I

The invention relates to the field of veterinary medicine and can be used for the treatment of gastrointestinal diseases of microbial etiology in young farm animals.

A known drug for the treatment of salmonellosis, colibacteriosis and microbial gastroenterocolitis in young animals of agricultural animals, containing kanamycin sulfate 1.

However, when using this drug, resistant forms of pathogens appear, and with large single and daily therapeutic and prophylactic doses, the drug has an insufficient efficiency (}).

The aim of the invention is to increase the prophylactic and therapeutic efficacy of the drug by reducing the dose of the antibiotic and reducing the resistant forms of the causative agents of these diseases.

This is achieved by the fact that the preparation additionally contains oxytetraschene hydrochloride, oxalic acid and powdered sugar in the following ratio of components,%:

Kanamycin sulfate6.0-10.0

Oxytetracycline hydrochloride 24.0-30.0 Oxalic acid4.0-6.0

Sugar powderEverything.

The combined use of oxytetracycline hydrochloride and kanamishna sulfate reduces the single and daily therapeutic and prophylactic doses of each antibiotic separately, as well as their toxic properties.

6.00 rO24, 00 4.00 Else.

8.70 rho26, 10 5.05 Else.

Claims (1)

10.00 Oxytetracycline hydrochloride30, 00 Oxalic acid6.00 Sugar powder Rest. The proposed complex preparation consists of 3 parts of oxytetracycline hydrochloride and 1 part of kanamycin sulfate. In 1 g of the drug contain 300,000 U of antibiotics. It is a yellow-green powder, odorless, sour in taste, readily soluble in De. The manufacturing technology of the drug has been mastered at the Kurgan Combine of Medical Preparations and Synthesis Products. It consists of the following: pre-dried (e, sifted through a sieve and weighted components of the preparation are placed in a clean, dry mixer. Mixing is carried out for 25-30 minutes until a homogeneous powder mass is obtained. The finished product is packaged in double plastic bags of 100 or 200 g As a result of the studies, it was found that the proposed drug is practically non-toxic (its DL5o dp mice are 4400 mg / kg), does not have a cumulative effect, does not cause abnormalities in laboratory animals oral administration in therapeutic and maximum tolerated doses. The proposed drug has a broad spectrum of antimicrobial action. It is active against gram-positive and gram-negative microbes. Particularly sensitive to the Salmonella Preparation and E. coli. Paratharas are administered orally in doses of 50-100 m (15000-30000 BD) per kg of animal weight. After oral administration of the preparation oxyTetracycline hydrochloride, it is absorbed and maintained in many organs for 12 hours at a level sufficient for a1 tibacterial of action. Kanamycin hardly absorbs from the gastrointestinal tract. In the experiment on laboratory animals and in experiments on farm animals under household conditions, it has been established that the proposed ratio of oxytetracycline hydrochloride and kanamidine sulfate gives a synergistic effect (increases the bacteriostatic effect by 2-3 times compared with individual components), allows reducing the dose drug and treatment time compared with the individual components, as well as the cost of treatment. Under the conditions of households on 3235 pigs, we studied the therapeutic effect of the proposed drug for salmonellosis, colibacterioeia, and for catarrhal and hemorrhagic gastroenterocolitis. As a result, it was found that the use of the proposed drug had a high therapeutic effect in these diseases. In the groups treated with the proposed drug, recovery occurred in 93.5-99.6% of sick animals, while the effectiveness of using kanamycin and oxytetracycline was 6% or more less. The proposed drug was applied to 9.5 thousand goal. pigs and 1.6 thousand goal. tel with gastroenterocolitis, salmonellosis, and if there are animals with hibernation. The recovery of animals after the use of the drug averaged 90-95% of the number of cases, and when using other antibiotics (drugs chlortetradiklin, neomishcha, etc.) did not exceed 90%. The recovery of the majority (80%) of sick animals occurred 2 days earlier than after the use of other drugs. The proposed drug also showed high efficiency of action on the microflora isolated from the feces of sick animals (B. Proteuss; Pseudomonas fluorescens; B. Pyocyaneus; B. Paracoli vulgaris; BB Paracoli N, 1, No. 3) - 80%, KOTOra significantly exceeds the effectiveness of kanamycin sulfate (66%) and oxytetracycline hydrochloride (20%). Of great importance is also the low cost of the drug: 1 kg of it in terms of chemically pure antibiotics costs 101 rubles. 66 kopecks / t. It is 4.5 times cheaper than 1 kg of oxytetracycline (450 rubles) or 2 times less than 1 kg of kanamycin (204 rubles). Vewooka's therapeutic efficacy of the drug and its low cost can significantly reduce the cost of treating animals. So for the treatment of 1 pig weighing 20 kg on average, 8.4 g of oxytetracycline in powder worth 3 rubles is needed. 78 cop. or 8.4 g kanamycin worth 1 rub. 71 kopecks, and in the treatment with the proposed preparation 8.4 g will be required at a cost of 86 kopecks. Formula for preparing a treatment for salmonellosis, colibacteriosis and gastroenterocolitis of microbial etiology in young agricultural animals, containing kanamycin sulfate, which is indicated by the fact that, in order to increase the prophylactic and therapeutic efficacy of the drug by reducing the dose of antibiotic and reducing resistant forms of antibiotics and reducing resistant forms of pathogens and reducing resistant pathogens. additionally contains oksitetradaklin hydrochloride, oxalic acid and powdered sugar in the following ratio of components,%: 5 Kanamycin with Oxytetracycline uldrohporid ulfate Oxalic acid Sugar powder 6.00-10.00 Sources of information, 24.00-30.001. Guidelines for the use of 4.00-6.00 antibiotics in veterinary medicine. - M., Kolos 1974, the Rest. 5 s. 16-17. 6926046 taken into account in the examination