SU686731A1 - Hair integument growth factor - Google Patents

Hair integument growth factor

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Publication number
SU686731A1
SU686731A1 SU731954519A SU1954519A SU686731A1 SU 686731 A1 SU686731 A1 SU 686731A1 SU 731954519 A SU731954519 A SU 731954519A SU 1954519 A SU1954519 A SU 1954519A SU 686731 A1 SU686731 A1 SU 686731A1
Authority
SU
USSR - Soviet Union
Prior art keywords
hair
growth factor
wool
growth
hair integument
Prior art date
Application number
SU731954519A
Other languages
Russian (ru)
Inventor
Михаил Григорьевич Воронков
Ада Тимофеевна Платонова
Елена Владимировна Половникова
Игорь Георгиевич Кузнецов
Валерий Михайлович Дьяков
Гунар Изидорович Зелчан
Наталья Семеновна Самошкина
Инна Ивановна Кольгуненко
Original Assignee
Иркутский институт органической химии СО АН СССР
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Иркутский институт органической химии СО АН СССР filed Critical Иркутский институт органической химии СО АН СССР
Priority to SU731954519A priority Critical patent/SU686731A1/en
Application granted granted Critical
Publication of SU686731A1 publication Critical patent/SU686731A1/en

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  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

II

Изобретение относитс  к медицине, касаетс  стимул тора роста волос ного покрова и может найти применение в косметологии , ветер1шарии.The invention relates to medicine, concerns a stimulator of hair growth and can be used in cosmetology, wind.

Известно вещество 1-замеще1шых силатрана формулы X - Si ()в которых х-углеводородный заместитель, функциональна  или карбофункциональна  группа, в качестве химического соединени  1.A 1-substituted silatrane substance of the formula X - Si () is known in which the x-hydrocarbon substituent, functional or carboxylic acid group, as chemical compound 1.

Целью изобретени   вл етс  ускорение роста волос ного покрова.The aim of the invention is to accelerate the growth of hair.

Это достигаетс  применением 1-замещенных силатрана общей ффмулы X-Si (OCH2CH2)jN , где х-углеводород- ный заместитель, функциональна  и кар- б.офункциональна  группа, в качестве стимул тора роста волос ного по1фова.This is achieved by using 1-substituted silatrane X-Si total formula (OCH2CH2) jN, where the x-hydrocarbon substituent, functional and car- bly functional group, as a hair growth stimulator.

Эти производные не токсичны otDg 1500 мг/кг. Они не обладают раздражающим или каким-либо другим побочным действием. Исследовани  проводились на 9О здоровых морских свинках с нормальным шерстным покровом.These derivatives are non-toxic otDg 1500 mg / kg. They do not have irritating or any other side effects. Studies were performed on 9O healthy guinea pigs with normal coat.

У животных состригают волосы с площади 1 см в области спины. Выстриженные волосы промьгаают эфиром (дл  удалени  гр зи), сушат и определ ют их вес (дл  характеристики густоты покрова волос животных). Затем берут 1/4 часть выстриженных волос (по весу) и подсчитьтают количество отдельных волосков. Зна  их вес и число, определ ют количество волосков во вз том образце. Кроме того, определ ют длину и толщину волос .In animals, hair is cut from an area of 1 cm in the back area. Shorn hair is washed with ether (to remove dirt), dried and their weight is determined (to characterize the thickness of the animal hair). Then take 1/4 of the clipped hair (by weight) and calculate the number of individual hairs. Knowing their weight and number, determine the number of hairs in the sample taken. In addition, the length and thickness of the hair is determined.

После вз ти  фона животным дают 5 раз в неделю вместе с пищей силатран в дозе 1О и 50 мг в день в течение 2 мес. Прирост шерсти более значителен в опытной группе, чем в контроле. При использовании Х-метил-силатран а в дозе 1О мг прирост шерсти составил 35%, а при дозе .50 мг- 40,5%.After taking the background, animals are given 5 times a week with food silatran at a dose of 1O and 50 mg per day for 2 months. Wool growth is more significant in the experimental group than in the control. When using X-methyl-silatran a at a dose of 10 mg, the increase in wool was 35%, and at a dose of 50 mg it was 40.5%.

При лечении маз ми, содержащими 5 и 10% 1-этокси-силатрана(мигугена) 1-этилсилатрана и 1-хлор метил-силатрана (мивала) лучший результат наблюдалс When treating ointments containing 5 and 10% 1-ethoxy-silatrane (migugen) 1-ethylsilane and 1-chloro methyl-silatrane (mival), the best result was observed

при применении 5% мази 1-этоксисилатрана . Прирост шерсти составил 55,4%, а 10% мази - 41,4%.when using 5% ointment 1-ethoxysilatran. The growth of wool was 55.4%, and 10% ointment - 41.4%.

При использовании мази, содержащей 5% 1-хлор метил-силатрана шерсть у жи-вотных отрастает в 1,5 раза быстрее. Прирост шерсти составил ЗО%.When using an ointment containing 5% 1-chloro methyl-silatran, wool in animals grows 1.5 times faster. The increase in wool was ZO%.

Проведенные исследовани  с использованием силатранов в виде мазей показали , что наибольшим стимулирующим действием на рост шерсти обладает 1-этоксисилатран , 1-метилсилатран и 1-хлорметилсилатран .Studies conducted with the use of silatranes in the form of ointments showed that 1-ethoxysilatrane, 1-methylsilatrane and 1-chloromethylsilatran has the greatest stimulating effect on the growth of wool.

Предлагаемые стимул торы роста волос ного покрова могут найти широкое применение в овцеводческих совхозах и зверосовхозах , а также в клинической практике дл  лечени  различных видов облысени  у людей.The proposed hair growth stimulants can be widely used in sheep state farms and animal farms, as well as in clinical practice for the treatment of various types of baldness in humans.

Claims (1)

1. Pupe Chem, 13,35, 1966.1. Pupe Chem, 13.35, 1966.
SU731954519A 1973-07-26 1973-07-26 Hair integument growth factor SU686731A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU731954519A SU686731A1 (en) 1973-07-26 1973-07-26 Hair integument growth factor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU731954519A SU686731A1 (en) 1973-07-26 1973-07-26 Hair integument growth factor

Publications (1)

Publication Number Publication Date
SU686731A1 true SU686731A1 (en) 1979-09-25

Family

ID=20563126

Family Applications (1)

Application Number Title Priority Date Filing Date
SU731954519A SU686731A1 (en) 1973-07-26 1973-07-26 Hair integument growth factor

Country Status (1)

Country Link
SU (1) SU686731A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19534201A1 (en) * 1995-09-15 1997-03-20 Lohmann Therapie Syst Lts Preparation for the prophylaxis and / or treatment of wool and hair loss

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19534201A1 (en) * 1995-09-15 1997-03-20 Lohmann Therapie Syst Lts Preparation for the prophylaxis and / or treatment of wool and hair loss

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