SU667545A1 - Method of producing dl-alpha-phenyl ethylamine - Google Patents
Method of producing dl-alpha-phenyl ethylamineInfo
- Publication number
- SU667545A1 SU667545A1 SU782592819A SU2592819A SU667545A1 SU 667545 A1 SU667545 A1 SU 667545A1 SU 782592819 A SU782592819 A SU 782592819A SU 2592819 A SU2592819 A SU 2592819A SU 667545 A1 SU667545 A1 SU 667545A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- producing
- alpha
- phenyl ethylamine
- target product
- ammonia
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Description
.;., I.;., I
Изобретение огносигс к усовёрШёнСгвованному способу получени DL -д1--фенилэтиламина , который находит широкое примбнениб в тонком органическом синтезе , .в органическом анализе в качестве ре« актива дл идентификации сложных эфиров и хлорангидридов карбонобых кислот путем превращени их в xtipoiuu кристйГлТтй- зующиес амиды,.а также как реагент дл разделени рацемических кислот на оптические антиподы.: ;The invention ognosigs usovorShonSgvovannomu to a process for preparing DL -d1 - phenylethylamine, which is widely primbnenib in fine organic synthesis, .in organic analysis as D 'for the asset identification esters and acid chlorides karbonobyh by converting them into xtipoiuu kristyGlTty- zuyuschies amides ,. as well as a reagent for the separation of racemic acids into optical antipodes:;
Известны разлйчньге способы получени рацемического оС -фенилэтиламина, например , известен способ получени DL - с1г-фе- нилэткламина восстанови тельным аминированием ацетофенона аммиаком в присутст ВИИ катализатора никел Рене при и давлении водорода 250-350 ат, выход целевого продукта составл ет 44-52% от теоретического 1,There are known methods for the preparation of racemic oC-phenylethylamine, for example, a method for producing DL - c1g-phenylethclamine by reducing amination of acetophenone with ammonia in the presence of a VIH catalyst of nickel at hydrogen pressure of 250-350 atm is known, the yield of the target product is 44-52% from theoretical 1,
Однако, этот способ имеет р д существенных недостатков, оснрвньпии из которых вл ютс жесткие услови процесса давление и температура, применение избытHowever, this method has a number of significant drawbacks, of which the strictest conditions of the process are pressure and temperature, the use of excess
ка аммиака, й,кйк следртвие stotb, сложность аппаратурного оформлени продесса, низкий выход целевого продукта.ka ammonia, y, kik sledrtvie stotb, the complexity of the hardware design of the process, the low yield of the target product.
.Наиболее близким к изобретению вл етс способ получени DL - оС-фенилэтил амина, основанный на аминировании ацегов фенона сухим муравтлнокислым аммиаком, заключайвдийс в том, что ацетофенон под- вергают взаимодействию с сухим муравьи- ноклслым аммонием при мольном соотно шенйи указанных реагентов 1:3,2 при 150-185 С, Образующийс в качестве промежуточного продукта оС -фенилэтил (рмамйД подвергают гидролизу когалентрированной сол ной кислотой и далее амин отгон ют с вод н151М паром, а целевой про дукт .выдел ют. известньпЛй приемами с вы .ходрм 6О-66% 2The closest to the invention is a method for producing DL-oC-phenylethyl amine, based on the amination of acetone phenone with dry formic ammonia, concludes that acetophenone reacts with dry formic ammonium in a molar ratio at a ratio of 8%. , 2 at 150-185 ° C. The resulting C as an intermediate product is C-phenylethyl (Dummy is subjected to hydrolysis with co-cycled hydrochloric acid, and then the amine is distilled off from water with 151M steam, and the target product is isolated using the procedure rm 6О-66% 2
Недостатками известного способа вл ютс низкий выход целевого продукта, боль шие затраты сырь и трудоемкость про«десса .The disadvantages of this method are the low yield of the target product, the higher costs of raw materials and the laboriousness of the pro- cess.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU782592819A SU667545A1 (en) | 1978-03-20 | 1978-03-20 | Method of producing dl-alpha-phenyl ethylamine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU782592819A SU667545A1 (en) | 1978-03-20 | 1978-03-20 | Method of producing dl-alpha-phenyl ethylamine |
Publications (1)
Publication Number | Publication Date |
---|---|
SU667545A1 true SU667545A1 (en) | 1979-06-15 |
Family
ID=20754537
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU782592819A SU667545A1 (en) | 1978-03-20 | 1978-03-20 | Method of producing dl-alpha-phenyl ethylamine |
Country Status (1)
Country | Link |
---|---|
SU (1) | SU667545A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5041669A (en) * | 1990-10-16 | 1991-08-20 | Hoechst Celanese Corporation | Process for the preparation of arylalkylamines and substituted arylalkylamines |
-
1978
- 1978-03-20 SU SU782592819A patent/SU667545A1/en active
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5041669A (en) * | 1990-10-16 | 1991-08-20 | Hoechst Celanese Corporation | Process for the preparation of arylalkylamines and substituted arylalkylamines |
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