SU625579A3 - Suturing material - Google Patents

Description

This invention relates to the field of medicine and concerns surgical sutures. Known suture material based on woven fibers with a polymer coating. However, the known suture material is not sufficiently strong at node 00, 11 and HO-WHzV-0- with "1Kg) t-C-0- (Sig). 1 is less than 9 and X is the degree of polymerization.

An increase in the strength of material.p, a decrease in its roughness is achieved by applying polyethers on its surface. I get Unich by polymerization of lactones or by the esterification of low molecular weight glycols with dimeric acid.35

Preferred coatings and formulations are polyethers of the reduced Fortsutal mol. 1500-5000, imparting at least two carbon bonds between the ester bonds in the polymer

chains and giving suture materials the best lubricating properties.

Particularly preferred polyesters are derivatives of 1,4-ubutanediol (() and adipic acid (t 4) with a molar weight of 2000-3000.

Branched molecular chain acids, for example, ft., (K, / 2 -trime ilbrobkova, 3,7-dimethyloctadienoEa, 1,4-cyclohexanecarboxylic, Mesa tones, /, ft-dimethylglutaric acid, dimeric acid, and diols with branched a molecular chain, such as diisononylglycol and glyco., having a secondary hydroxyl group, such as 1,2-propylene glycol, and has a detrimental effect on the surface. The purpose of the invention is to increase the strength of the material in the assembly. with mol. weight 1000-15000 form. p. t fl II - C- (C-0-1C1Hg) gGON can be added to the reaction mixture in small quantities as self-adapters for the preparation of polyethers used as coating materials with a melting point above room temperature. Polyesters are suitable for production of suture materials. Polymerization of lactones can also be obtained. Such polyethers are characterized by a melting point higher than cm / m temperature and have the formula (SCg) in which P is an integer greater than 2 and H is the degree of polymerization. Preferred is polyester, mol%. about 2000, obtained by polymerization of S capralactones in the presence of polymethylene diol. Polyester coating compositions are non-toxic and can be applied to the suture from a solution. The suture can be woven, spun or have a surface layer. The suture is then dried in air to remove the solvent and form a continuous surface coating. The composition of the surface coating (0.5 - 5% based on the weight of the suture material) does not have a destructive effect on the working strength or durability. The use of more than 5% by weight of the composition of the surface coating causes an improvement in the lubricating properties, but can adversely affect other physical properties of the suture, especially the stability of the nodes. Example. The polymer condensation product is obtained by reacting 42.5% by weight of 1,4-butanediol with 57.5 ve of adipic acid. The polymer obtained is a wax-like solid. The body has a viscosity of 1475 SP at 60 ° C mol%. 2150, acid number 1.7 and hydroxyl number 52.1. Polyester (4.84 wt. 4.) Solution in 95.16 parts by weight. toluene and the solution are applied to a 2/0 woven strand made from a poly-thylene terephthalate suture using a yarn application tool. Weaving is covered with the following words: yarn speed - 9 m / min; ipoddermichesky size - 30 speed motor drive - 10 obA1In; Testing with a hysteresis of 2 kg. The coated braided strand is air dried at 21-26.5 ° C to evaporate the solvent and then collected on the surface of the drum. Adipic acid curing is not required. The coating is continuously on the entire surface of the suture and is up to 1 wt.% {Based on the weight of the suture not subjected to treatment). Weaving coated sterilized by irradiation with cobalt at..ves.60 without significant loss of tensile strength or durability of the nodes. Polyester resin is used for rocking silk woven, cotton and collagen sutures. However, for hydrophilic substrates such as cotton and silk, higher levels of coating solids are used. The coated suture materials produced according to this example have good holding properties for the node o Example 2. Polycaprolactone is dissolved in toluene to obtain a 3.8% (by weight) solution. This solution is applied to a woven strand of polyethylene terephthalate suture / ia (2/0 in size) using an Atlab applicator for yarn trimming. The weave is coated under the conditions described in Example 1 and dried with air being blown in. The coated weave after evaporation of the solvent is collected on the surface of the drum. Polycaprolactone does not need to be cured, rokryty continuously across the surface of the suture material and is up to 1 wt.% (Based on the weight of the suture material, not processed). Weaving r coated sterilized, irradiated with cobalt without appreciable loss of tensile strength or knot strength. The physical properties of the woven polyethylene terephthalate suture ds and after coating are shown in the table.

Strength, kg / cm:

non-sterile material sterile

The strength of knots

kg / cm:

sterile non-sterile material Roughness, kg

6440 6405

3619 3619 0.47

The same results are obtained if polycaprolactone is used to coat suture materials of 2 / 0-6 / 0 of woven silk, cotton yarn and callagen. The proposed suture was tested in a variety of surgical procedures. The suture has no adverse or adverse effects; it is inert and retains excellent strength 3 knots.

but- (CIS) „- o - (s.Ng) tcc-o- (cis) goat s- (1Hg) tcc-o- (cis) p-one

where HG is an integer greater than one and less than 13, W is an integer greater than 1 and less than 9, k is the degree of polymerization.

II

Sources of information taken into account in the examination:

Claims (1)

1. US patent No. 3527650, 45: class. 117-7, 1970. The proposed suture can be applied in general thoracic and cardiovascular surgery. Claims of Invention Suture material on. based on woven fibers with a polymer coating, characterized in that, in order to increase the strength of the material in the assembly, the coating is a polyester with a molecular weight. 1000-15000 formulas