SU523908A1 - - Polyethylene piperazine oxide - Google Patents
- Polyethylene piperazine oxideInfo
- Publication number
- SU523908A1 SU523908A1 SU2108276A SU2108276A SU523908A1 SU 523908 A1 SU523908 A1 SU 523908A1 SU 2108276 A SU2108276 A SU 2108276A SU 2108276 A SU2108276 A SU 2108276A SU 523908 A1 SU523908 A1 SU 523908A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- oxide
- polyethylene piperazine
- polyethylene
- piperazine oxide
- oxides
- Prior art date
Links
Description
Изобретение касаетс нового химическо го соединени , а именно N -окиси полиэтиленпиперазина формулы N Х-СН2- 2Н2 о о где л 5О-4ОО. N -Окись полиэтиленпиперазина вл етс физиологически а тивным веществом и может быть использована дл лечени и профилактики силикоза. Известен способ получени полимерных N -окисей, например N -окиси поли-2поли-4-винилпирвдина , которые вл ютс и гибиторами экспериментального силикоза. О нако N -окиси поливинилпиридина содержат токсичное дл организма пиридиновое дро и, будучи устойчивыми к биодеструкци накапливаютс в организме, что приводит к новообразовани м. Известен также способ получени полимерной N -окиси 1,2-этиленпиперидина и 1,2-метиленпирролидина, макромолекулы ко торых содержат гетероатом азота в основной цепи и не имеют токсичных пиридиновых дер. Синтез указанных веществ св зан с большими трудност ми из-за недоступности исходных компонентов. С целью расширени класса биологически активных веществ, обладающих противосиликсзной активностью и самодеструктирующих в организме, синтезировано новое вещество - N -окись полиэтиленпиперазина, содержаща активную N -окисную группу в основной цепи макромолекулы. Наличие в полимерной цепи св зи С N - О способствует биодеструкции полимера до низкомолекул рных продуктов, способных выводитьс из организма, N -Окись полиэтиленпиперазина синтезируют из легко доступного мономера, который выпускают в промышленных масштабах. N-Окись полиэтиленпиперазина получают окислением полиэтиленпиперазина 30%-ной перекисью водорода в разбавленных слабокислых водных или водноспиртовых растворах . Синтез провод т при температуре доThe invention relates to a new chemical compound, namely N-polyethylene piperazine oxide of the formula N X-CH 2 -2H 2 o where l is 5O-4OO. N-polyethylene piperazine oxide is a physiologically active substance and can be used to treat and prevent silicosis. A method is known for producing polymeric N-oxides, for example, N-poly-2-poly-4-vinylpyrvidine N-oxides, which are also the beaters of experimental silicosis. Polyvinylpyridine's N-oxides contain a pyridine nucleus that is toxic to the body and, being resistant to biodegradation, accumulate in the body, which leads to new growths. They contain a nitrogen heteroatom in the main chain and do not have toxic pyridine nuclei. The synthesis of these substances is associated with great difficulties due to the unavailability of the starting components. In order to expand the class of biologically active substances with antisilictic activity and self-destructing in the body, a new substance has been synthesized - N-polyethylene piperazine containing the active N-oxide group in the macromolecule main chain. The presence in the polymer chain of the C – N – O bond contributes to the biodegradation of the polymer to low molecular weight products that can be eliminated from the body; N-Polyethylene piperazine oxide is synthesized from an easily available monomer, which is produced commercially. Polyethylene piperazine N-oxide is obtained by oxidation of polyethylene piperazine with 30% hydrogen peroxide in dilute weakly acidic aqueous or hydroalcoholic solutions. The synthesis is carried out at temperatures up to
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU2108276A SU523908A1 (en) | 1975-02-24 | 1975-02-24 | - Polyethylene piperazine oxide |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU2108276A SU523908A1 (en) | 1975-02-24 | 1975-02-24 | - Polyethylene piperazine oxide |
Publications (1)
Publication Number | Publication Date |
---|---|
SU523908A1 true SU523908A1 (en) | 1976-08-05 |
Family
ID=20611085
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU2108276A SU523908A1 (en) | 1975-02-24 | 1975-02-24 | - Polyethylene piperazine oxide |
Country Status (1)
Country | Link |
---|---|
SU (1) | SU523908A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5503830A (en) * | 1993-09-10 | 1996-04-02 | Petrovax, L.L.C. | Compounds having immunostimulating activity and methods of use thereof |
WO2011162639A1 (en) * | 2010-06-24 | 2011-12-29 | ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "НПО Петровакс Фарм" | Heterochain aliphatic poly-n-oxide copolymers and vaccinating agents and drugs based thereon |
RU2737271C2 (en) * | 2018-06-27 | 2020-11-26 | ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "НПО Петровакс Фарм" | COPOLYMERS OF di-N-OXIDES OF POLY-1,4-ETHYLENE-PIPERAZINE AND METHODS FOR PRODUCTION THEREOF |
-
1975
- 1975-02-24 SU SU2108276A patent/SU523908A1/en active
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5503830A (en) * | 1993-09-10 | 1996-04-02 | Petrovax, L.L.C. | Compounds having immunostimulating activity and methods of use thereof |
WO2011162639A1 (en) * | 2010-06-24 | 2011-12-29 | ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "НПО Петровакс Фарм" | Heterochain aliphatic poly-n-oxide copolymers and vaccinating agents and drugs based thereon |
US9155759B2 (en) | 2010-06-24 | 2015-10-13 | Obchtchestvo S Ogranitchennoi Otvestvennostyou “Npo Petrovaks Farm” | Heterochain aliphatic poly-N-oxide copolymers and vaccinating agents and drugs based thereon |
RU2737271C2 (en) * | 2018-06-27 | 2020-11-26 | ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "НПО Петровакс Фарм" | COPOLYMERS OF di-N-OXIDES OF POLY-1,4-ETHYLENE-PIPERAZINE AND METHODS FOR PRODUCTION THEREOF |
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