SU503513A3 - Method for preparing substituted arylsulfonylurea - Google Patents

Method for preparing substituted arylsulfonylurea

Info

Publication number
SU503513A3
SU503513A3 SU1768163A SU1768163A SU503513A3 SU 503513 A3 SU503513 A3 SU 503513A3 SU 1768163 A SU1768163 A SU 1768163A SU 1768163 A SU1768163 A SU 1768163A SU 503513 A3 SU503513 A3 SU 503513A3
Authority
SU
USSR - Soviet Union
Prior art keywords
arylsulfonylurea
preparing substituted
substituted
group
alkyl
Prior art date
Application number
SU1768163A
Other languages
Russian (ru)
Inventor
Эчерь Золтан
Херман Юдит
Терек Золтан
Ланьи Кальман
Шомфай Ева
Ковач Вера
Надьдьеши Дьердь
Original Assignee
Хиноин Дьедьсер -Еш Ведьесети Термекек Дьяра Рт (Инопредприятие)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Хиноин Дьедьсер -Еш Ведьесети Термекек Дьяра Рт (Инопредприятие) filed Critical Хиноин Дьедьсер -Еш Ведьесети Термекек Дьяра Рт (Инопредприятие)
Application granted granted Critical
Publication of SU503513A3 publication Critical patent/SU503513A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

(54) СПОСОБ ПОЛУЧЕНИЯ ЗАМЕЩЕННОЙ АРИЛСУЛЬФОНИЛМОЧЕВИНЫ(54) METHOD FOR OBTAINING A SUBSTITUTED Arylsulfonylmode

1one

Изобретение относитс  к способу получени  замещенной арилсульфонилмочевины общей формульThis invention relates to a process for the preparation of substituted arylsulfonylureas of general formulas.

;302-MH-CO-NHR2i; 302-MH-CO-NHR2i

где RI - водород, гадоид, алкил с Ci - Се, алкоксил, амине-, аш ламино- или адиламиноалки группа , причем ашшгрупиа может быть замещена галовдом.алкилом или алкоксилом; Rj-алкил с С, -GS или -циклоалккл с Са -Cj, обладающей биологачески активными свойствами.where RI is hydrogen, gadoid, alkyl with Ci - Ce, alkoxyl, amine-, al-lamino-or adylaminoalkyl group, and the group may be substituted by halo-alkyl or alkoxyl; Rj-alkyl with C, -GS or -cycloalkl with Ca -Cj, which has biologically active properties.

Как известно, производные замещенной мочевины наход т разнообразное примене1ше в медищ не и сельском хоз йстве,Derivatives of substituted urea are known to be found in a variety of applications in medicine and agriculture,

Известен способ получени  замеще1юых бензосульфонилмочевпны взаимодействием бензолоульфамида или его comi и изоцнанатам, уретанами, хлорангидридами карбамнновой кислоты.A known method for the preparation of substitution benzosulfonylureas by the interaction of benzolulfamide or its comi and isocyanates, urethanes, and carbamic acid chlorides.

Однако в известном способе высокий расход дорогосто щих исходных веществ, полученных многостадийным синтезом, приводит к снижеш1ю эффективности этого процесса.However, in the known method, a high consumption of expensive starting materials obtained by multistage synthesis leads to a decrease in the efficiency of this process.

Поэтому с целью упрощени  процесса, в последнем, согласно {побретению, амид арилсульфокислоть взаимодействует с амидогм тригалоидуксусной кислоты.Therefore, in order to simplify the process, in the latter, according to {tenders, arylsulfonic acid amide reacts with trihaloacetic acid amide.

предложенный способ состоит в том, что арилсульфамид общейфррмулыThe proposed method consists in the fact that arylsulfamide general formula

.-о.-about

ЗОдКН2,IDN2,

I)I)

где RJ имеет вышеуказанные значени , или его соль взаимодействует с амидом тригалоидуксусной ислоты общей формулы where RJ is as defined above, or its salt is reacted with a trihaloacetic acid amide of the general formula

Hge-, Hge-,

HgB-C -CONHT , IHgB-C-CONHT, I

ЧH

где RJ имеет выщеуказанные значени . Алкилгруппа - грут1па с С, - С, с пр мой или разветвленной цепью. Ащ1лгруппа - остаток алифатической кислоты с пр мой или разветвленной цепью, предпочтительно ацетил, или остаток ароматической кислоты, преимущественно бензоил, или остаток гетероциклической кислоты, содержащей 1,2 гетероатома , предпочтительно nHpa3rHffKap6oroin.where RJ is as defined above. An alkyl group is a group with C, C, with a straight or branched chain. Alkaline is a straight or branched chain aliphatic acid residue, preferably acetyl, or an aromatic acid residue, preferably benzoyl, or a heterocyclic acid residue containing 1,2 heteroatoms, preferably nHpa3rHffKap6oroin.

Причем, адилгруппа может замещена галоидом , алкилом Или ал1соксилом.Moreover, the adyl group may be substituted by halogen, alkyl, or allyloxy.

Алкоксетруппа - предпочтительно метоксилAlkoxetroup - preferably methoxy

или этоксил. Циклоалкилгруппа преимущественноor ethoxyl. Cycloalkyl group

содержит С4 -Су; Rj предпочтительно Щ1клогекcontains C4-Su; Rj is preferably Sch1clogek

SU1768163A 1971-04-06 1972-04-05 Method for preparing substituted arylsulfonylurea SU503513A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HUCI001096 HU162761B (en) 1971-04-06 1971-04-06

Publications (1)

Publication Number Publication Date
SU503513A3 true SU503513A3 (en) 1976-02-15

Family

ID=10994401

Family Applications (1)

Application Number Title Priority Date Filing Date
SU1768163A SU503513A3 (en) 1971-04-06 1972-04-05 Method for preparing substituted arylsulfonylurea

Country Status (13)

Country Link
JP (1) JPS5227149B1 (en)
AT (1) AT315191B (en)
CH (1) CH580070A5 (en)
CS (1) CS166908B1 (en)
DD (1) DD99161A1 (en)
DE (1) DE2213602A1 (en)
DK (1) DK134011B (en)
GB (1) GB1334471A (en)
HU (1) HU162761B (en)
NO (1) NO138139C (en)
PL (1) PL83532B1 (en)
SE (1) SE396600B (en)
SU (1) SU503513A3 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2807708C1 (en) * 2023-03-28 2023-11-21 Акционерное общество "Щелково Агрохим" Method of nicosulfuron production

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI69303C (en) * 1984-01-19 1986-01-10 Medica Pharma Co Ltd PROCEDURE FOR THE FRAMEWORK OF THE PHARMACOLOGICAL PROPERTIES
CN107434788B (en) * 2017-09-11 2018-06-15 威海迪素制药有限公司 A kind of preparation method of Glipizide

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2807708C1 (en) * 2023-03-28 2023-11-21 Акционерное общество "Щелково Агрохим" Method of nicosulfuron production
RU2821509C1 (en) * 2023-12-18 2024-06-25 Акционерное общество "Щелково Агрохим" Method of producing tolbutamide
RU2827153C1 (en) * 2024-03-11 2024-09-23 Акционерное общество "Щелково Агрохим" Method of producing herbicide nicosulfuron

Also Published As

Publication number Publication date
AT315191B (en) 1974-05-10
PL83532B1 (en) 1975-12-31
NO138139C (en) 1978-07-12
HU162761B (en) 1973-04-28
DE2213602A1 (en) 1972-10-12
CH580070A5 (en) 1976-09-30
DK134011B (en) 1976-08-30
CS166908B1 (en) 1976-03-29
DD99161A1 (en) 1973-07-20
NO138139B (en) 1978-04-03
SE396600B (en) 1977-09-26
GB1334471A (en) 1973-10-17
JPS5227149B1 (en) 1977-07-19
DK134011C (en) 1977-01-31

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