SU486016A1 - The method of producing nicotinoylethylenediamine or its salts - Google Patents
The method of producing nicotinoylethylenediamine or its saltsInfo
- Publication number
- SU486016A1 SU486016A1 SU1932557A SU1932557A SU486016A1 SU 486016 A1 SU486016 A1 SU 486016A1 SU 1932557 A SU1932557 A SU 1932557A SU 1932557 A SU1932557 A SU 1932557A SU 486016 A1 SU486016 A1 SU 486016A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- nicotinoylethylenediamine
- salts
- producing
- ethylene diamine
- yield
- Prior art date
Links
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- Pyridine Compounds (AREA)
Description
3 Пример 2. В указанных в примере 1 уелоВИЯХ провод т взаимодействие этилендиамина и этилового эфира никотиновой кислоты. После отгонки избытка этилендиамина закристаллизовавшуюс массу раствор ют в.5 смеси нормального бутанола и 25%-него аммиака в соотношении 5:1 и пропускают через колонку с силикагелем, промыва такой же смесью бутанола и аммиака. Затем отгон ют .растворитель на роториом «спарите-10 ле цри 40°С, подкисл ют разбавленной (1:1) сол ной кислотой до рП 2-3 и упарив ают досуха. Выход сырого продукта 36 г (76%); т. пл. 215°С. После перекристаллизации из этанола т. пл. 230°С; выход 23 г.15 4 Предмет изобретени 1. Способ получени никотиноилэтилендиамина или его солей ацилированием этилендиамина , отличающийс тем, ч го, с целью новышени выхода и упрощени процесса , этилендиамин подвергают взаимодействию с алкиловым эфиром никотиновой кислоты пр« нагревании, отгон ют избыток этилендиамина, обрабатывают реакционную смесь кислотой и выдел ют целевой продукт в виде соли или перевод т его в свободное ос«ование известными приемами. 2. Способ по п. 1, отличающийс тем, что процесс ведут при кипении этилендиамина.3 Example 2. In the procedure indicated in Example 1, ethylene diamine and nicotinic acid ethyl ester are reacted. After distilling off the excess ethylene diamine, the crystallized mass is dissolved in 5 of a mixture of normal butanol and 25% ammonia in a 5: 1 ratio and passed through a column of silica gel, washing with the same mixture of butanol and ammonia. Then, the solvent is distilled off on a rotor of a "pair-10 bar 40 ° C, acidified with diluted (1: 1) hydrochloric acid to rP 2-3, and evaporated to dryness. Crude yield 36 g (76%); m.p. 215 ° C. After recrystallization from ethanol, m.p. 230 ° C; yield 23 g.15 4 Subject of the invention 1. The method for producing nicotinoylethylenediamine or its salts by acylation of ethylene diamine, characterized in that, in order to increase the yield and simplify the process, ethylene diamine is reacted with heating of the nicotinic acid alkyl ether, distilled off the excess ethylene diamine, treat the reaction mixture with acid and isolate the target product as a salt or convert it to free separation using known techniques. 2. A method according to claim 1, characterized in that the process is carried out at the boiling of ethylenediamine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU1932557A SU486016A1 (en) | 1973-06-14 | 1973-06-14 | The method of producing nicotinoylethylenediamine or its salts |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU1932557A SU486016A1 (en) | 1973-06-14 | 1973-06-14 | The method of producing nicotinoylethylenediamine or its salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU486016A1 true SU486016A1 (en) | 1975-09-30 |
Family
ID=20556713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1932557A SU486016A1 (en) | 1973-06-14 | 1973-06-14 | The method of producing nicotinoylethylenediamine or its salts |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU486016A1 (en) |
-
1973
- 1973-06-14 SU SU1932557A patent/SU486016A1/en active
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