SU479768A1 - The method of producing pyrimidine derivatives - Google Patents
The method of producing pyrimidine derivativesInfo
- Publication number
- SU479768A1 SU479768A1 SU1953849A SU1953849A SU479768A1 SU 479768 A1 SU479768 A1 SU 479768A1 SU 1953849 A SU1953849 A SU 1953849A SU 1953849 A SU1953849 A SU 1953849A SU 479768 A1 SU479768 A1 SU 479768A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- pyrimidine derivatives
- producing pyrimidine
- alkyl
- producing
- picrate
- Prior art date
Links
Landscapes
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Description
пиримидин. Выход 24%, т. кип. 163-165° С; т. пл. пикрата 226° С.pyrimidine. Yield 24%, kp. 163-165 ° C; m.p. picrate 226 ° C.
Пример 2. 10 мл 30%-ного иминаExample 2. 10 ml of 30% imine
МеСН N-С-NMe2 проиускают над катаIIMeCH N-C-NMe2 is generated over Kata II
||
ОABOUT
лизатором в стандартных услови х. Катализатор обрабатывают 5 мл концентрированной серной кислоты, затем раствором едкого кали , отфильтровывают выиавшую соль, а из фильтрата экстрагируют целевой продукт. Н-Метилпиримидон-2 получают с выходом 35%; т. пл. пикрата 160° С.under standard conditions. The catalyst is treated with 5 ml of concentrated sulfuric acid, then with caustic potassium solution, the distilled salt is filtered off, and the target product is extracted from the filtrate. H-Methylpyrimidone-2 is obtained in a yield of 35%; m.p. picrate 160 ° C.
Пример 3. 10 Л1Л 30%-ного спиртовогоExample 3. 10 L1L 30% alcohol
О IIAbout II
раствора имина МеСН N C-МНСНгОН пропускают над катализатором при 400° С и выдел ют пиримидинон-2, как описано в примере 2. Выход 25%; т. пл. пикрата 198° С.an imine solution of MeCH N C-MHHNHON is passed over the catalyst at 400 ° C and pyrimidinone-2 is isolated as described in example 2. Yield 25%; m.p. picrate 198 ° C.
Предмет изобретени Subject invention
1. Способ получени производных пиримидина общей формулы1. A process for the preparation of pyrimidine derivatives of the general formula
,,
II
RR
где R, RI и R,where R, RI and R,
атом водорода или алкил; X - группа С О или СН-алкил, отличающийс тем, что, с целью упрощени технологического процесса дегидроциклизации в присутствии алюмохромокалиевого катализатора при 350-400° С подвергают имины общей формулыa hydrogen atom or an alkyl; X is a C O or CH-alkyl group, characterized in that, in order to simplify the process, dehydrocyclization in the presence of an aluminum-chromium catalyst at 350-400 ° C is subjected to imines of the general formula
RCH NXN-CHgRRCH NXN-CHgR
RR
R - алкил,R is alkyl,
R - атом водорода или алкил;R is a hydrogen atom or an alkyl;
- атом водорода, оксигруппа, алкил - hydrogen atom, hydroxy group, alkyl
или алкилиден; Xимеет указанные выще значени .or alkylidene; It has the above values.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU1953849A SU479768A1 (en) | 1973-08-01 | 1973-08-01 | The method of producing pyrimidine derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU1953849A SU479768A1 (en) | 1973-08-01 | 1973-08-01 | The method of producing pyrimidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU479768A1 true SU479768A1 (en) | 1975-08-05 |
Family
ID=20562916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1953849A SU479768A1 (en) | 1973-08-01 | 1973-08-01 | The method of producing pyrimidine derivatives |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU479768A1 (en) |
-
1973
- 1973-08-01 SU SU1953849A patent/SU479768A1/en active
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