SU466233A1 - Method for producing 2-methyl-4-dialkylaminoalkylaminoquinazoline derivatives - Google Patents
Method for producing 2-methyl-4-dialkylaminoalkylaminoquinazoline derivativesInfo
- Publication number
- SU466233A1 SU466233A1 SU1932177A SU1932177A SU466233A1 SU 466233 A1 SU466233 A1 SU 466233A1 SU 1932177 A SU1932177 A SU 1932177A SU 1932177 A SU1932177 A SU 1932177A SU 466233 A1 SU466233 A1 SU 466233A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- methyl
- producing
- derivatives
- dialkylaminoalkylaminoquinazoline
- hydrogen
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
(54) СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ 2-МЕТИЛ-4ДИАЛКИЛАМИНОАЛКИЛАМИНОХИНАЗОЛИНА(54) METHOD FOR OBTAINING DERIVATIVES OF 2-METHYL-4 DIAHYL-ALINO ALKYLAMINOHINAZOLINE
1212
экстракт иро.мывают водой, сушат и упаривают . Остаток переКристаллизовьГВают из гептана . Получают 7,04 г целевого продукта (т. пл. 104-105° С) в виде бесцветных кристаллов, хорошо растворимых в эфи1ре, ххлороформе, ацетоне, энилацетате, спиртах, хуже растворимых IB гептане, нерастворимых ,в .В0,де. Выход 70%.extract iro.myvayut water, dried and evaporated. The residue is recrystallized from heptane. Obtain 7.04 g of the desired product (mp. 104-105 ° C) as colorless crystals, well soluble in ether, chloroform, acetone, enil acetate, alcohols, worse than soluble IB heptane, insoluble, in .B0, de. Yield 70%.
Найдено, %: С 72,23; Н 9,28; N 18,85.Found,%: C 72.23; H 9.28; N 18.85.
CisHas.CisHas.
18,65.18.65.
%: С 71,96; Н 9,39; N %: C, 71.96; H 9.39; N
Вычислено, могут быть получены сCalculated can be obtained with
АналогичноSimilarly
выходом 77-95%; наа1рпмер, 2-метал-4-д«эт,илай1ииоэтила-мнлохииазолин , 2,6-д.имет.ил-4-дн1метиламиноэтиламИ1нохиназол и н , 2-iMет1ил-4-дИметил ам1И1Н01П|рОП-ил аМИНО-6-.мето сихИназол1ИН.yield 77-95%; Naa1rpmer, 2-metal-4-d "et, illyiiioethyl-mnlohiazoline, 2,6-dimethyl-4-dnmethylaminoethylaminoquinazol and n, 2-iMet1yl-4-dImethyl sihInazol1IN.
Предмет изобретени Способ получени произ,водных 2-метил-4диалкила1 Ы ноал1К1Нла1М 1 НОХИ|назол:Ина оощеи формулыThe subject of the invention. Method for producing prod, aqueous 2-methyl-4-dialkyl 1 S Noal 1 C 1 N 1 1 M 1 NOHI | Design: Inoshe formulas
Л.L.
NH-A-ЯСNH-A-YAS
пдеR - ато-м водорода (Или галогена,pdeR - atoms of hydrogen (or halogen,
ал1какси;Г1руп1па ил1И алкил;al1acci; G1up1pa il1I alkyl;
RI 1Й Ra - алкил;RI 1Y Ra is alkyl;
А - нормальный или рааветвленный углаводоро дный р.адвкал, отличающийс те.м, что производное 2-метил-4-хлор|Х|Иназоли .на (подвергают .взаИМОдействию с дйалкила .миноалюиламашом ,в среде /imepTiHoro растворител .A is a normal or branched hydrogen / hydrogen branch, characterized by the fact that 2-methyl-4-chloro | X | Inazoli is a derivative (subjected to interaction with dialkyl, aluminoylmash, in the medium / imepTiHoro solvent.
2. Cnocoi6 по п. 1, отличающийс тем, что процесс провод т лри температуре ниже 100° С.2. Cnocoi6 according to claim 1, characterized in that the process is carried out at a temperature below 100 ° C.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU1932177A SU466233A1 (en) | 1973-06-08 | 1973-06-08 | Method for producing 2-methyl-4-dialkylaminoalkylaminoquinazoline derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU1932177A SU466233A1 (en) | 1973-06-08 | 1973-06-08 | Method for producing 2-methyl-4-dialkylaminoalkylaminoquinazoline derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
SU466233A1 true SU466233A1 (en) | 1975-04-05 |
Family
ID=20556604
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU1932177A SU466233A1 (en) | 1973-06-08 | 1973-06-08 | Method for producing 2-methyl-4-dialkylaminoalkylaminoquinazoline derivatives |
Country Status (1)
Country | Link |
---|---|
SU (1) | SU466233A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996019474A1 (en) * | 1994-12-22 | 1996-06-27 | Warner-Lambert Company | Quinazolines as inhibitors of endothelin converting enzyme |
USRE41065E1 (en) | 1995-06-06 | 2009-12-29 | Pfizer, Inc. | Alkynl and azido-substituted 4-anilinoquinazolines |
RU2694252C2 (en) * | 1995-03-30 | 2019-07-10 | Пфайзер Продактс Инк. | Derivatives of 4-(substituted phenylamino)qyinazoline or pharmaceutically acceptable salts thereof, method of inhibiting receptor tyrosine kinase and pharmaceutical composition |
-
1973
- 1973-06-08 SU SU1932177A patent/SU466233A1/en active
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996019474A1 (en) * | 1994-12-22 | 1996-06-27 | Warner-Lambert Company | Quinazolines as inhibitors of endothelin converting enzyme |
US5658902A (en) * | 1994-12-22 | 1997-08-19 | Warner-Lambert Company | Quinazolines as inhibitors of endothelin converting enzyme |
RU2694252C2 (en) * | 1995-03-30 | 2019-07-10 | Пфайзер Продактс Инк. | Derivatives of 4-(substituted phenylamino)qyinazoline or pharmaceutically acceptable salts thereof, method of inhibiting receptor tyrosine kinase and pharmaceutical composition |
USRE41065E1 (en) | 1995-06-06 | 2009-12-29 | Pfizer, Inc. | Alkynl and azido-substituted 4-anilinoquinazolines |
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