SU45287A1 - The method of cleaning weak solutions of morphine - Google Patents

Description

For the isolation of morphine from very weak aqueous solutions of it (uterus, obtained in the production of opiate alkaloids, extra poppy plants, etc.) there is no such method that would have practical value. Methods that offer the extraction of morphine with any solvents require very large quantities of these solvents and, therefore, are not applicable in production. Deposition of morphine with ammonia or some other base requires that the solution have a sufficiently large concentration of morphine, i.e., weak solutions of morphine must be concentrated accordingly.

Zi; However, it is not possible to achieve the concentration required for precipitating morphine by simple evaporation of weak solutions, since these solutions usually contain simultaneously with morphine and various extractives of both organic and inorganic nature in amounts (50-100 times or more) superior to morphine. Thus, it is clear that in order to achieve the concentration of the morphine necessary for the settlement of the morphine, the latter must first be removed from the solution by the main mass of the Ey: travative substances contained in it. .

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The author's certificate No. 28154 describes a method for cleaning such solutions using alcohol treatment. However, this method requires a very high cost of alcohol, which makes getting morphine in this way quite expensive.

The author of the present invention proposes a new method for purifying weak solutions of morphine, which lacks these disadvantages and consists of the following. Weak morphine solutions are treated with lime, filtered from precipitates, acidified, and evaporated. During evaporation, crystalline precipitates are precipitated, which are filtered off from the solution as they are evaporated. In this way, it is possible to evaporate the solution to the desired concentration of morphine, and the latter can be isolated from the resulting concentrated solution by conventional methods.

If significant amounts of such substances are contained in the solution, which are difficult or not crystallized completely during evaporation (e.g., proteins, etc.), as is the case when morphine is obtained from the poppy plant extract, then the above methods, i.e. by lime treatment, evaporation and filtration from precipitation, yet

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it is not yet possible to bring the solution to the desired concentration of morphine. In this case, it is necessary to add a double, triple amount of alcohol to the one stripped off solution obtained above. At the same time fall amorphous, resinous precipitates of dark color. The alcohol solution separated from the resin is evaporated to the whole; a thick state, the residue is diluted with a small amount of water or a weak alcohol, and the morphine is separated from the solution obtained by usual methods.

This method achieves the possibility of relatively cheap production of morphine from the queen cells in the production of opi alkaloids, and, most importantly, the production of morphine from a poppy plant is made available and profitable.

The subject matter of the invention.

Claims (2)

1. A method for purifying weak morphine with an impurity by treatment with lime, characterized in that after processing the solutions with lime, separating the precipitated precipitates and acidifying them and evaporating the precipitates are filtered several times, after which the morphine is separated from the concentrated solution using conventional methods. , 2. A variation of the method according to claim 1 for extracting from an extract from a poppy plant, characterized in that the one stripped off morphine solution prepared according to claim 1 is processed as indicated in the author's certificate No. 38154.