SU430106A1 - METHOD OF OBTAINING O-DIALKYL (DIARYL) -8- [2-OXY-3- (PENTIASYNYL-10) - PROPYL] DITIOPHOSPHATES - Google Patents
METHOD OF OBTAINING O-DIALKYL (DIARYL) -8- [2-OXY-3- (PENTIASYNYL-10) - PROPYL] DITIOPHOSPHATESInfo
- Publication number
- SU430106A1 SU430106A1 SU1761265A SU1761265A SU430106A1 SU 430106 A1 SU430106 A1 SU 430106A1 SU 1761265 A SU1761265 A SU 1761265A SU 1761265 A SU1761265 A SU 1761265A SU 430106 A1 SU430106 A1 SU 430106A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- propyl
- diaryl
- dialkyl
- obtaining
- pentiasynyl
- Prior art date
Links
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Description
1one
Изобретение относитс к области получени эфиров дитиофосфорных кислот, а именно к способу получени новых О,0-диалкил (диарил) - S - 2-окси-З - (фентиазинил-10)пропил дитиофосфатов общей формулыThe invention relates to the field of the preparation of dithiophosphoric acid esters, namely to a process for the preparation of new O, 0-dialkyl (diaryl) - S-2-hydroxy-3 - (fentiazinyl-10) propyl dithiophosphates of the general formula
5 Q5 Q
(RO)PS-CH2-CH-CH.2F S(RO) PS-CH2-CH-CH.2F S
ОНHE
где R - а л кил или а рил. where R is a l kil or a reel.
Эти соединени могут быть использованы в качестве физиологически активных веществ.These compounds can be used as physiologically active substances.
Способ получени О,О-диалкил (диарил)-S 2-окси-3- (фентиазинил-10) - пропил - дитиофосфатов общей формулы основан на известной реакции дитиофосфорных кислот с а-окис ми , котора , однако, ранее не примен лась дл синтеза соединений аналогичной структуры .The method of obtaining O, O-dialkyl (diaryl) -S 2-hydroxy-3- (fentiazinyl-10) -propyl-dithiophosphates of the general formula is based on the known reaction of dithiophosphoric acids with a-oxides, which, however, has not previously been used for synthesis of compounds of similar structure.
10- (2,3-эпоксипропил) Согласно способу, фбнтиазин формулы10- (2,3-epoxypropyl) According to the method, fbntiazin formula
СНг-СН-СНг- 1SNg-CH-SNg- 1
подвергают взаимодействию с О,О-диалкилили О,О-диарилдитиофосфорной кислотой формулыsubjected to interaction with O, O-dialkylamino, O-diaryldithiophosphoric acid of the formula
SS
(RO),PSH(RO), PSH
где R - алкил или арил.where R is alkyl or aryl.
Процесс провод т при нагревании в среде инертного органического растворител , например бензола.The process is carried out by heating in an inert organic solvent, such as benzene.
После 10-15 час кип чени реакци заканчиваетс и целевые продукты выдел ют известными приемами. Выход очищенных продуктов 60-85%.After 10-15 hours of boiling, the reaction is complete and the desired products are isolated by known methods. The yield of purified products 60-85%.
Пример 1. О,О-дип,ропил-8- 2-окси-3 (фентиазинил-10)-лропил - дитиофосфат. К бензольному раствору, содержащему 3,2 гExample 1. O, O-dip, ropyl-8-2-hydroxy-3 (fentiazinyl-10) -propyl-dithiophosphate. To benzene solution containing 3.2 g
(0,015 г-моль) дипропилдитиофосфорной кислоты прикапывают при перемешивании бензольный раствор, содержащий 2,56 г (0,01 г моль) 10-(2,3-эпоксипропил) - фентиазина, перемещйвают при комнатной температуре в(0.015 g-mol) of dipropyl dithiophosphoric acid are added dropwise with stirring a benzene solution containing 2.56 g (0.01 g of mol) of 10- (2,3-epoxypropyl) -phenthiazine, moved at room temperature to
течение 1 час. Затем нагревают 15 час при температуре кипени растворител . Растворитель отгон ют, остаток промывают несколько раз эфиром от избытка дитиофосфорной кислоты . Продукт очищают переосаждением изfor 1 hour Then it is heated for 15 hours at the boiling point of the solvent. The solvent is distilled off, the residue is washed several times with ether from an excess of dithiophosphoric acid. The product is purified by reprecipitation of
бензольного раствора петролейным эфиром.benzene solution with petroleum ether.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU1761265A SU430106A1 (en) | 1972-03-20 | 1972-03-20 | METHOD OF OBTAINING O-DIALKYL (DIARYL) -8- [2-OXY-3- (PENTIASYNYL-10) - PROPYL] DITIOPHOSPHATES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU1761265A SU430106A1 (en) | 1972-03-20 | 1972-03-20 | METHOD OF OBTAINING O-DIALKYL (DIARYL) -8- [2-OXY-3- (PENTIASYNYL-10) - PROPYL] DITIOPHOSPHATES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU430106A1 true SU430106A1 (en) | 1974-05-30 |
Family
ID=20507149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1761265A SU430106A1 (en) | 1972-03-20 | 1972-03-20 | METHOD OF OBTAINING O-DIALKYL (DIARYL) -8- [2-OXY-3- (PENTIASYNYL-10) - PROPYL] DITIOPHOSPHATES |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU430106A1 (en) |
-
1972
- 1972-03-20 SU SU1761265A patent/SU430106A1/en active
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