SU365988A1 - - Google Patents

Description

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The invention relates to the field of use of an antioxidant group for the stabilization of carotene in grass meal and other carotene-containing feed products.

It is known that a number of antioxidants are used to preserve carotene in grass meal and feed products, of which the drug called ethoxyquin or santochin is the most common.

However, the production of ethoxyquine is associated with a number of technological difficulties, its cost is quite high. In addition, the storage and use of ethoxyquin in animal husbandry is associated with inconveniences, since ethoxyquin is a thick liquid that is easily oxidized in air.

It is proposed to use 2,6-dimethyl-3,5-dicarbetoxy-1,4-dihydropyridine as an antioxidant stabilizer of carotene in grass flour and other carotene-containing feed products (1)

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The proposed drug can be obtained by simple technology from the available starting materials. It is a crystalline compound that remains unchanged in air for a long time and is convenient for use.

Antioxidant properties of the drug (1) are shown in model experiments: it inhibits thermal oxidation of a mixture of ethyl esters of unsaturated fatty acids at 37 ° C by 52%, and also inhibits autooxidation of linetol emulsion (conc.) By 57% (40 ° C, b h ), in the presence of 5-10-M FeSOi-on 59%.

Methods for stabilizing carotene are illustrated with examples of stabilizing carotene in grass meal and compound feed.

The preparation, according to the laboratory of pharmacology of the Institute of Organic Synthesis of the Academy of Sciences of the Latvian SSR, is completely non-toxic in acute experience, a dose of 32,000 mg / kg of body weight.

for white mice, oral administration does not show a toxic effect. A dose of ethoxyquin 5000 mg / kg body weight is lethal. No significant deviations from the norms were found in chronic experiments on white rats for 6 months-Dose 2 and 20 mg / kg of the preparation (1) daily. The use of the drug (1) in a dose of 200-300 mg / kg of live weight in chickens (daily, up to 30 days of age) does not cause pathoanatomical and biochemical changes.

A biological study of the effect of the proposed drug and ethoxyquin added with grass meal to the feed was carried out with bacon fattening of pigs (on 48 heads of young animals, 12 heads in each group). It was established that feeding mixed feeds with grass flour stabilized by the preparation (1) for 98 days of experience ensured that average daily weight gain increased from 634 to 711 g, or 13.7% compared to the control, reduced feed consumption by 10.4% and digestible protein by 11.0%. Thus, 6.5 month old pigs have a live weight of 96.7 kg. The bacon produced is of high quality.

With the introduction of grass meal stabilized by the proposed drug, the vitamin A deposition in pigs liver increases from 7.7 to 15.6 kg / g or 2 times compared with feeding the feed with unstabilized grass flour.

Example. In the experiment on the study of the stabilizing effect of the drug (compared to ethoxyquin) on carotene in grass meal in

Production experience (batches of 500 kg of grass and flour each) showed that the drug has a slightly better stabilizing effect on the carotene of grass meal than ethoxyquin. Molasses (10%) and antioxidants (200 g per 1 ton of dry flour, in the form of a solution in isopropyl alcohol) were injected with the aid of the SDM-ZA unit. Herbal flour was stored in a floor-type warehouse. The content of carotene in the samples was determined monthly for six months according to the working method for the determination of carotene in vitamin grass flour, according to GOST 6604-53. Temperature and relative power were measured three times a day.

The preparation, used in the form of a powder, also gives a good preservation of carotene in grass flour: for 5 months of storage - 145 mg / kg of grass flour (in the control - 120 mg / kg of grass flour).

Data on the safety of carotene in the compound feed with unstabilized and stabilized grass meal for 6 months (the content of carotene in the feed at the beginning of storage of 9.15 mg / kg) is given in the table.

Subject invention

The use of 2,6-dimethyl-3,5-dicarbethoxy, 4-dihydropyridine as an antioxidant

to stabilize carotene in grass meal and other carotene-containing feed products.