SU322999A1 - СПОСОБ ПОЛУЧЕНИЯ 3-МЕТИЛОВОГО ЭФИРА ЭСТРАДИОЛА-17р - Google Patents
СПОСОБ ПОЛУЧЕНИЯ 3-МЕТИЛОВОГО ЭФИРА ЭСТРАДИОЛА-17рInfo
- Publication number
- SU322999A1 SU322999A1 SU1437780A SU1437780A SU322999A1 SU 322999 A1 SU322999 A1 SU 322999A1 SU 1437780 A SU1437780 A SU 1437780A SU 1437780 A SU1437780 A SU 1437780A SU 322999 A1 SU322999 A1 SU 322999A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- estradiol
- methyl ether
- obtaining
- methyl ester
- mixture
- Prior art date
Links
- 238000000034 method Methods 0.000 title description 8
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 9
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 6
- 229960005309 estradiol Drugs 0.000 description 6
- 229930182833 estradiol Natural products 0.000 description 6
- AQRLNPVMDITEJU-UHFFFAOYSA-N triethylsilane Chemical compound CC[SiH](CC)CC AQRLNPVMDITEJU-UHFFFAOYSA-N 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- 238000007127 saponification reaction Methods 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 150000000319 19-nortestosterones Chemical class 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 150000004678 hydrides Chemical class 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000000707 stereoselective effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU1437780A SU322999A1 (ru) | 1970-06-12 | 1970-06-12 | СПОСОБ ПОЛУЧЕНИЯ 3-МЕТИЛОВОГО ЭФИРА ЭСТРАДИОЛА-17р |
| DE19712106753 DE2106753C3 (de) | 1970-06-12 | 1971-02-12 | Sterisch gerichtetes Verfahren zur Herstellung von östratrienverbindungen mit natürlicher Konfiguration |
| CH233871A CH585232A5 (enExample) | 1970-06-12 | 1971-02-18 | |
| GB649971*[A GB1346691A (en) | 1970-06-12 | 1971-03-10 | Stereospecific method for preparing estrane compounds of natural configuration |
| YU79171A YU34300B (en) | 1970-06-12 | 1971-03-31 | Stereospecific process for preparing estrane compounds of natural cofiguration |
| PL14763071A PL83267B1 (enExample) | 1970-06-12 | 1971-04-19 | |
| FR7120706A FR2100753A1 (en) | 1970-06-12 | 1971-06-08 | Oestranes - by reducing delto 8(9)-dehydrooestranes with - trifluoroacetic acid and |
| HUII000062 HU165082B (enExample) | 1970-06-12 | 1971-06-11 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU1437780A SU322999A1 (ru) | 1970-06-12 | 1970-06-12 | СПОСОБ ПОЛУЧЕНИЯ 3-МЕТИЛОВОГО ЭФИРА ЭСТРАДИОЛА-17р |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU322999A1 true SU322999A1 (ru) | 1973-08-10 |
Family
ID=20452901
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1437780A SU322999A1 (ru) | 1970-06-12 | 1970-06-12 | СПОСОБ ПОЛУЧЕНИЯ 3-МЕТИЛОВОГО ЭФИРА ЭСТРАДИОЛА-17р |
Country Status (6)
| Country | Link |
|---|---|
| CH (1) | CH585232A5 (enExample) |
| FR (1) | FR2100753A1 (enExample) |
| HU (1) | HU165082B (enExample) |
| PL (1) | PL83267B1 (enExample) |
| SU (1) | SU322999A1 (enExample) |
| YU (1) | YU34300B (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3119276B1 (fr) | 2021-01-27 | 2022-12-09 | Psa Automobiles Sa | Dispositif de supervision d’un systeme electrique comprenant une machine redondee |
-
1970
- 1970-06-12 SU SU1437780A patent/SU322999A1/ru active
-
1971
- 1971-02-18 CH CH233871A patent/CH585232A5/xx not_active IP Right Cessation
- 1971-03-31 YU YU79171A patent/YU34300B/xx unknown
- 1971-04-19 PL PL14763071A patent/PL83267B1/pl unknown
- 1971-06-08 FR FR7120706A patent/FR2100753A1/fr active Granted
- 1971-06-11 HU HUII000062 patent/HU165082B/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU165082B (enExample) | 1974-06-28 |
| FR2100753B1 (enExample) | 1975-04-18 |
| PL83267B1 (enExample) | 1975-12-31 |
| YU34300B (en) | 1979-04-30 |
| CH585232A5 (enExample) | 1977-02-28 |
| FR2100753A1 (en) | 1972-03-24 |
| YU79171A (en) | 1978-10-31 |
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