SU270740A1 - METHOD OF OBTAINING AMINO ETHANOLAL SALT PHENYLETHYLACETIC ACID - Google Patents
METHOD OF OBTAINING AMINO ETHANOLAL SALT PHENYLETHYLACETIC ACIDInfo
- Publication number
- SU270740A1 SU270740A1 SU1259224A SU1259224A SU270740A1 SU 270740 A1 SU270740 A1 SU 270740A1 SU 1259224 A SU1259224 A SU 1259224A SU 1259224 A SU1259224 A SU 1259224A SU 270740 A1 SU270740 A1 SU 270740A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- salt
- ethanolal
- obtaining amino
- acetic acid
- phenylethylacetic
- Prior art date
Links
- OBKXEAXTFZPCHS-UHFFFAOYSA-N 4-phenylbutyric acid Chemical compound OC(=O)CCCC1=CC=CC=C1 OBKXEAXTFZPCHS-UHFFFAOYSA-N 0.000 title description 9
- -1 AMINO Chemical class 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 239000011780 sodium chloride Substances 0.000 title 1
- HZAXFHJVJLSVMW-UHFFFAOYSA-N ethanolamine Chemical class NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N iso-propanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- OBBCMAHJFIJQIK-UHFFFAOYSA-N 2-hydroxyethylazanium;2-phenylbutanoate Chemical compound NCCO.CCC(C(O)=O)C1=CC=CC=C1 OBBCMAHJFIJQIK-UHFFFAOYSA-N 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 241000219758 Cytisus Species 0.000 description 1
- SKHXHUZZFVMERR-UHFFFAOYSA-L Isopropyl citrate Chemical compound CC(C)OC(=O)CC(O)(C([O-])=O)CC([O-])=O SKHXHUZZFVMERR-UHFFFAOYSA-L 0.000 description 1
- 239000002310 Isopropyl citrate Substances 0.000 description 1
- 235000010495 Sarothamnus scoparius Nutrition 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000000871 hypocholesterolemic Effects 0.000 description 1
- 230000001077 hypotensive Effects 0.000 description 1
- 235000019300 isopropyl citrate Nutrition 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Description
Изобретение относитс к способу получени медицинского препарата - цетамифена, представл ющего собой аминоэтаноловую соль фенилэтилуксусной кислоты.The invention relates to a method for producing a medical preparation, cetamifen, which is an aminoethanol salt of phenylethyl acetic acid.
Цетамифен обладает гипохолестеринемическим действие.м, оказывает также умеренный гипотензивный эффект, малотоксичен.Cetamiphen has a hypocholesterolemic effect. M, also has a moderate hypotensive effect, low toxicity.
Известен способ получени аминоэтаноловой соли фенилэтилуксусной кислоты (цетамифена ), заключающийс во взаимодействии фенилэтилуксусной кислоты и моноэтаноламила в среде бензола.A known method for the preparation of the aminoethanol salt of phenylethyl acetic acid (cetamiphene) involves the interaction of phenylethyl acetic acid and monoethanolamyl in a benzene medium.
Дл увеличени выхода целевого продукта предложен способ получени аминоэтаноловой соли фенилэтилуксусной кислоты, заключающийс во взаимодействии фенилэтилуксусной кислоты и моноэтаноламина в среде абсолютного изопропилощого спирта. Выход целевого продукта 80% от теоретического.In order to increase the yield of the target product, a method has been proposed for the preparation of the aminoethanol salt of phenylethyl acetic acid, which consists in the interaction of phenylethyl acetic acid and monoethanolamine in an environment of absolute isopropyl alcohol. The yield of the target product 80% of theoretical.
Пример. В стальной эмалированный аппарат с мещалкой, обратным холодильником, рубащкой дл обогрева паром и охлаждени водой загружают абсолютный изопропиловый спирт и фенилэтилуксусную кислоту в соотнощении 2-: 1. К раствору фенилэтилуксусной 4Example. Absolute isopropyl alcohol and phenylethyl acetic acid are added to a steel enamelled apparatus with a mechalka, a reflux condenser, a jacket for heating with steam and cooling with water in a 2-: 1 ratio. To a solution of phenylethylacetic 4
кислоты при работающей мещалке приливают эквимолекул рное количество моноэтаноламина . Дл полноты реакции смесь выдерживают при размещивании в течение 4 час. Затем реакционную массу нагревают до 63-65°С и фильтруют через воронку дл гор чей фильтрации в сборник.Acids with a running broom make equimolecular amount of monoethanolamine. For completeness of the reaction, the mixture was incubated for 4 hours. Then the reaction mass is heated to 63-65 ° C and filtered through a funnel for hot filtration into a collector.
После охлаждени выпавщие кристаллы цетамифена отжимают на нутч-фильтре, промывают абсолютным изопропнловым спиртом и сущат при 35-45°С. Выход цетамифена 80% от теоретического.After cooling, precipitated crystals of cetamiphen are squeezed out on a suction filter, washed with absolute isopropyl alcohol and present at 35-45 ° C. The yield of cetamiphen 80% of theoretical.
Предмет изобретени Subject invention
Способ получени аминоэтаноловой соли фенилэтилуксусной кислоты взаимодействием фенилэтилуксусной кислоты с моиоэтаноламииом в среде органического растворител , отличающийс тем, что, с целью увеличени выхода целевого продукта и упрощени процесса , в качестве растворител используют абсолютный изопропиловый сцирт.A method of producing aminoethanol salt of phenylethyl acetic acid by reacting phenylethyl acetic acid with myoethanolamia in an organic solvent, characterized in that, in order to increase the yield of the target product and simplify the process, absolute isopropyl citrate is used as solvent.
Publications (1)
Publication Number | Publication Date |
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SU270740A1 true SU270740A1 (en) |
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