SU246529A1 - WAY OF OBTAINING DERIVATIVES 2-OXO-3,4-DIBROM-2,5- - Google Patents

WAY OF OBTAINING DERIVATIVES 2-OXO-3,4-DIBROM-2,5-

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Publication number
SU246529A1
SU246529A1 SU1257322A SU1257322A SU246529A1 SU 246529 A1 SU246529 A1 SU 246529A1 SU 1257322 A SU1257322 A SU 1257322A SU 1257322 A SU1257322 A SU 1257322A SU 246529 A1 SU246529 A1 SU 246529A1
Authority
SU
USSR - Soviet Union
Prior art keywords
oxo
dibrom
way
obtaining derivatives
derivatives
Prior art date
Application number
SU1257322A
Other languages
Russian (ru)
Original Assignee
Э. Ю. Гудриниеце, Я. Я. Паулиньш , И. К. Калнин Рижский политехнический институт
Publication of SU246529A1 publication Critical patent/SU246529A1/en

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Изобретение относитс  к области получени  новых соединений, которые могут найти применение в синтезе биологически активных веществ .The invention relates to the field of obtaining new compounds that can be used in the synthesis of biologically active substances.

Предлагаетс  способ получени  новых производных 2-оксо-3,4-дибром-2,5-дигидрофурана формулыA method for the preparation of new 2-oxo-3,4-dibromo-2,5-dihydrofuran derivatives of the formula

Вг./ВРVG / BP

О/СООСаН ,O / SOOSaN,

где R -СН(СООС2Н5)2,-СН ;where R is -CH (COOC2H5) 2, -CH;

СОСН,Ssn,

-СП(СОСНз)2, -CH2NO2, заключающийс  в том, что броммуконовую кислоту подвергают взаимодействию с соответствующим производным , содержащим активную метиленовую группу, в присутствии бикарбоната натри  при температуре не выше 70°С с последующим выделением полученного продукта известным способом. Врем  реакции мин. , Выход продукта 30-88%.-SP (COCH3) 2, -CH2NO2, which implies that bromo moonic acid is reacted with the corresponding derivative containing the active methylene group in the presence of sodium bicarbonate at a temperature not higher than 70 ° C, followed by isolation of the resulting product in a known manner. Reaction time min. The yield of the product is 30-88%.

Пример 20 г бикарбоната натри  и 52 г броммуконовой кислоть раствор ют в 600 мл воды, прибавл ют 40 мл нитрометана и нагревают 5-10 мин до полного растворени  нитрометана (температура не должна превыщать 70°С). Раствор охлаждают до 18-20°С,Example 20 g of sodium bicarbonate and 52 g of bromo muconic acid are dissolved in 600 ml of water, 40 ml of nitromethane are added and the mixture is heated for 5-10 minutes until the nitromethane is completely dissolved (the temperature should not exceed 70 ° C). The solution is cooled to 18-20 ° C.

прибавл ют 100 мл концентрированной сол ной кислоты и перекристаллизовывают из этилового спирта.100 ml of concentrated hydrochloric acid is added and recrystallized from ethyl alcohol.

Получают 53 г (88%) продукта с т. пл. 120-121 °С. ИКС VCD лактон 1778, Obtain 53 g (88%) of product with so pl. 120-121 ° C. ICS VCD Lactone 1778,

1611,Vj,.o 1568 сдг-1.1611, Vj, .o 1568 cdg-1.

Найдено, %: N4,56.Found,%: N4,56.

CgHsOiN.CgHsOiN.

Вычислено, %: N 4,67.Calculated,%: N 4.67.

Предмет изобретени Subject invention

Способ получени  производных 2-оксо-3,4 .JIJ дибром-2,5-дигидрофурана формулыMethod for preparing 2-oxo-3,4. JIJ derivatives of dibromo-2,5-dihydrofuran of formula

Вг.Vg

ВгVg

о  about

00

/СООС,Н5/ SOOS, H5

где R -СИ (СООСаНд) г, -СНwhere R is SI (SOOSaD) g, -CH

СОСН,Ssn,

-СН(СОСНз)2, -CHsNOa, отличающийс  тем, -CH (COCH3) 2, -CHsNOa, characterized in

5 что броммуконовую кислоту подвергают взаимодействию , с соответствующим производным, содерл ащим активную метиленовую группу, в присутствии бикарбоната натри  при температуре не выще 70°С с последующим выделением полученного продукта известным способом.5 that bromo muconic acid is reacted, with the corresponding derivative containing the active methylene group, in the presence of sodium bicarbonate at a temperature not higher than 70 ° C, followed by isolation of the resulting product in a known manner.

SU1257322A WAY OF OBTAINING DERIVATIVES 2-OXO-3,4-DIBROM-2,5- SU246529A1 (en)

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Publication Number Publication Date
SU246529A1 true SU246529A1 (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109468332A (en) * 2018-11-29 2019-03-15 上海交通大学 Application of the 1,2 dioxygenase encoding gene of bromine catechol in synthesis 2- bromine muconic acid

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109468332A (en) * 2018-11-29 2019-03-15 上海交通大学 Application of the 1,2 dioxygenase encoding gene of bromine catechol in synthesis 2- bromine muconic acid

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