SU235012A1 - METHOD FOR OBTAINING Y-ACYL (AROIL) -Y'- HYDROXAMUREIDES - Google Patents
METHOD FOR OBTAINING Y-ACYL (AROIL) -Y'- HYDROXAMUREIDESInfo
- Publication number
- SU235012A1 SU235012A1 SU1199224A SU1199224A SU235012A1 SU 235012 A1 SU235012 A1 SU 235012A1 SU 1199224 A SU1199224 A SU 1199224A SU 1199224 A SU1199224 A SU 1199224A SU 235012 A1 SU235012 A1 SU 235012A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- acyl
- hydroxamureides
- obtaining
- aroyl
- aroil
- Prior art date
Links
- 125000003435 aroyl group Chemical group 0.000 claims description 7
- 125000002252 acyl group Chemical group 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- MQCKJEXXPCMUMU-UHFFFAOYSA-N N-[amino-[4-[5-[4-[amino(nitroso)methylidene]cyclohexa-2,5-dien-1-ylidene]furan-2-ylidene]cyclohexa-2,5-dien-1-ylidene]methyl]hydroxylamine Chemical compound C1=CC(=C(NO)N)C=CC1=C(C=C1)OC1=C1C=CC(=C(N)N=O)C=C1 MQCKJEXXPCMUMU-UHFFFAOYSA-N 0.000 claims 1
- IQPQWNKOIGAROB-UHFFFAOYSA-N [N-]=C=O Chemical compound [N-]=C=O IQPQWNKOIGAROB-UHFFFAOYSA-N 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 description 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 2
- NHTMVDHEPJAVLT-UHFFFAOYSA-N isooctane Chemical compound CC(C)CC(C)(C)C NHTMVDHEPJAVLT-UHFFFAOYSA-N 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- UWQIEDGNGUIPKS-UHFFFAOYSA-N C1=CC=CC=C1.CC(C)CC(C)(C)C Chemical compound C1=CC=CC=C1.CC(C)CC(C)(C)C UWQIEDGNGUIPKS-UHFFFAOYSA-N 0.000 description 1
- 125000000174 L-prolyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(*)=O 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- MXOQNVMDKHLYCZ-UHFFFAOYSA-N benzamidoxime Chemical compound ON=C(N)C1=CC=CC=C1 MXOQNVMDKHLYCZ-UHFFFAOYSA-N 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000000875 corresponding Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 150000002513 isocyanates Chemical class 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000000361 pesticidal Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Description
Изобретение относитс к способу получени не известных рапее N-ацил (ароил)-К-гидроксамуреидов общей формулыThis invention relates to a process for the preparation of the unknown N-acyl (aroyl) -K-hydroxamureides of the general formula
.RI.RI
//
R - со - NH - с - NH - с/R - co - NH - s - NH - s /
юнyoung
где R - замещенный или незамещенный алкил или арил, R- арил, которые дшгут найти ирименен 1е в качестве физиологически активных веществ.where R is substituted or unsubstituted alkyl or aryl, R is aryl, which will be used to find irimene 1e as physiologically active substances.
Способ получени N-ацил (ароил)-К-гидроксамуреидов основан на взаимодействии соответствующих ацил (ароил):изоцианатов с нужными амидоксимами. Реакиию можно провести в широком интервале температур в среде органического растворител илп без него.The method of obtaining N-acyl (aroyl) -K-hydroxamureides is based on the interaction of the corresponding acyl (aroyl): isocyanates with the desired amidoximes. Reakia can be carried out in a wide range of temperatures in an organic solvent or without it.
Во всех случа х реакции проход т гладко и целевые про/тукты получают с достаточио высокими выходами.In all cases, the reactions proceed smoothly and target pro / tukts are obtained in sufficiently high yields.
Таким образом, предлагаемым способом можно с хорошим выходом получать ранее не оиисанные N-ацил (ароил) -1 -гидроксамуре11ды , широко использу их дл синтеза нового класса соединений с веро тной пестицпдной активностью.Thus, using the proposed method, N-acyl (aroyl) -1 -hydroxamurea 11y are not previously synthesized, which are widely used to synthesize a new class of compounds with probable pesticidal activity, with a good yield.
бензамидоксима в 20 мл бензола. Мгновенио выпадает белый студенистый осадок, который прн добавлен ни изооктана стал мелкокристаллическим . После сто ни в течение 10 .иин продукт отфильтровывают, промывают изооктаном , сушат и а воздухе и получают 0,61 N-бензоил-Х-беизогидроксамуреида. Продукт иосле перекрпсталлизации из смеси бензол --изооктан имеет т. пл. 167-168°С.benzamidoxime in 20 ml of benzene. Instantly a white gelatinous precipitate falls out, which is not added to iso-octane, it became fine-crystalline. After standing for 10 hours, the product is filtered off, washed with iso-octane, dried and air, and 0.61 N-benzoyl-X-beisohydroxamureide is obtained. The product after re-installation from a mixture of benzene - isooctane has an mp. 167-168 ° C.
Найдено. %: С 63,29; 62,20; И 4,34; 4,16: N 15,00: 15,06.Found %: C 63.29; 62.20; And 4.34; 4.16: N 15.00: 15.06.
Ci.Hi3N,03.Ci.Hi3N, 03.
Вычислено, %: С 63,60; Н 4,59; N 14,84.Calculated,%: C 63.60; H 4.59; N 14.84.
Аналогично пол)чены и очищены остальные N-ацил (ароил) -Х-гидроксамуреиды, характеристики которых приведены в таблице.Similarly, the remaining N-acyl (aroyl) -X-hydroxamureides, the characteristics of which are listed in the table, are purified and purified.
Предмет изобретени Subject invention
2020
Claims (2)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU235012A1 true SU235012A1 (en) |
Family
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