SU209454A1 - - Google Patents
Info
- Publication number
- SU209454A1 SU209454A1 SU1108408A SU1108408A SU209454A1 SU 209454 A1 SU209454 A1 SU 209454A1 SU 1108408 A SU1108408 A SU 1108408A SU 1108408 A SU1108408 A SU 1108408A SU 209454 A1 SU209454 A1 SU 209454A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- arylsulfonyl
- solvent
- arsoan
- mol
- followed
- Prior art date
Links
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- VZGDMQKNWNREIO-UHFFFAOYSA-N Carbon tetrachloride Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- YXHKONLOYHBTNS-UHFFFAOYSA-N diazomethane Chemical compound C=[N+]=[N-] YXHKONLOYHBTNS-UHFFFAOYSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N methylene dichloride Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 241000607479 Yersinia pestis Species 0.000 description 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 239000012442 inert solvent Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000003505 mutagenic Effects 0.000 description 1
- 231100000219 mutagenic Toxicity 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- -1 p-toluenesulfonylchloralimine Chemical compound 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000000087 stabilizing Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Description
СПОСОБ ПОЛУЧЕНИЯ 1-АРИЛСУЛЬФОНИЛ-2-ТРИХЛОРМЕТИЛЭТИЛЕНИМИДОВMethod of producing 1-arylsulfonyl-2-trichloromethyl-ethyleneimides
. Изобретение касаетс способа получени 1 -- арилсульфонил-2-трихлорметилэтиленимндов , которые в литературе не описаны.. The invention relates to a process for the preparation of 1-arylsulfonyl-2-trichloromethylethylene impend, which are not described in the literature.
Ацилэтиленимиды широко примен ютс в качестве средств дл лечени злокачественных опухолей, дл борьбы с вредител ми сельскохоз йственных культур (хемостерилизаци ), как мутагенные соединени , дл производства активных красителей, дл стабилизации галогенсодержащих полимеров и т. д.Acylethylenimides are widely used as agents for the treatment of malignant tumors, for combating pests of agricultural crops (chemosterilization), as mutagenic compounds, for the production of active dyes, for stabilizing halogen-containing polymers, etc.
Предлагаетс способ получени этих соединений взаимодействием арилсульфонилхлоральиминов с диазометаном по следующей схеме:A method is proposed for preparing these compounds by reacting arylsulfonyl chloroalimines with diazomethane according to the following scheme:
ArSOaN СН - CCIa+CHaNa- -ArSOaN - СН - СС1зArSOaN CH - CCIa + CHaNa- -ArSOaN - CH - CC1h
СНCH
Процесс ведут в среде инертного растворител при температуре ниже 5°С с последующим выделением целевых продуктов обычными методами.The process is carried out in an inert solvent at a temperature below 5 ° C, followed by separation of the target products by conventional methods.
Пример. В колбу помещают эфирный раствор диазометана (0,12 моль), добавл ю в течение 5 мин раствор п-толуолсульфонилхлоральимина (0,1 моль) в смеси эфира и хлористого метилена при температуре реакционной массы 0-5° С. Реакционную массу выдерживают 1 час, после чего растворитель отгон ют , а остаток кристаллизуют из смеси четыреххлористого углерода и пентана. Выход 75%,Example. An ether solution of diazomethane (0.12 mol) was placed in a flask, and a solution of p-toluenesulfonylchloralimine (0.1 mol) in a mixture of ether and methylene chloride was added at a temperature of the reaction mass of 0-5 ° C over a period of 5 min. The reaction mass was kept for 1 hour after which the solvent is distilled off, and the residue is crystallized from a mixture of carbon tetrachloride and pentane. 75% yield
т. пл. 107-109° С.m.p. 107-109 ° C.
Предмет изобретени Subject invention
Способ получени 1-арилсульфонил-2-трихлорметилэтиленимидов , отличающийс тем, что, с целью получени веществ, обладающих физиологическим действием, арилсульфонилхлоральимин подвергают взаимодействиюThe method of obtaining 1-arylsulfonyl-2-trichloromethylethylenimides, characterized in that, in order to obtain substances having a physiological effect, arylsulfonylchloroimine is reacted
с дназометаном в среде инертного органического растворител при температуре ниже 5° С с последующим выделением целевого продукта обычными приемами.with dnasomethane in an inert organic solvent at a temperature below 5 ° C, followed by separation of the target product by conventional methods.
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU209454A1 true SU209454A1 (en) |
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